Effects of Transcranial Alternating Current Stimulation on Repetitive Finger Movements in Healthy Humans
Transcranial alternating current stimulation (tACS) is a noninvasive neurophysiological technique that can entrain brain oscillations. Only few studies have investigated the effects of tACS on voluntary movements. We aimed to verify whether tACS, delivered over M1 at beta and gamma frequencies, has...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2018/4593095 |
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| author | Andrea Guerra Matteo Bologna Giulia Paparella Antonio Suppa Donato Colella Vincenzo Di Lazzaro Peter Brown Alfredo Berardelli |
| author_facet | Andrea Guerra Matteo Bologna Giulia Paparella Antonio Suppa Donato Colella Vincenzo Di Lazzaro Peter Brown Alfredo Berardelli |
| author_sort | Andrea Guerra |
| collection | DOAJ |
| description | Transcranial alternating current stimulation (tACS) is a noninvasive neurophysiological technique that can entrain brain oscillations. Only few studies have investigated the effects of tACS on voluntary movements. We aimed to verify whether tACS, delivered over M1 at beta and gamma frequencies, has any effect on repetitive finger tapping as assessed by means of kinematic analysis. Eighteen healthy subjects were enrolled. Objective measurements of repetitive finger tapping were obtained by using a motion analysis system. M1 excitability was assessed by using single-pulse TMS and measuring the amplitude of motor-evoked potentials (MEPs). Movement kinematic measures and MEPs were collected during beta, gamma, and sham tACS and when the stimulation was off. Beta tACS led to an amplitude decrement (i.e., progressive reduction in amplitude) across the first ten movements of the motor sequence while gamma tACS had the opposite effect. The results did not reveal any significant effect of tACS on other movement parameters, nor any changes in MEPs. These findings demonstrate that tACS modulates finger tapping in a frequency-dependent manner with no concurrent changes in corticospinal excitability. The results suggest that cortical beta and gamma oscillations are involved in the motor control of repetitive finger movements. |
| format | Article |
| id | doaj-art-797d608371ed4cf78949fc31fa3dc4f3 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-797d608371ed4cf78949fc31fa3dc4f32025-02-03T01:09:41ZengWileyNeural Plasticity2090-59041687-54432018-01-01201810.1155/2018/45930954593095Effects of Transcranial Alternating Current Stimulation on Repetitive Finger Movements in Healthy HumansAndrea Guerra0Matteo Bologna1Giulia Paparella2Antonio Suppa3Donato Colella4Vincenzo Di Lazzaro5Peter Brown6Alfredo Berardelli7Neuromed Institute IRCCS, Pozzilli, ItalyNeuromed Institute IRCCS, Pozzilli, ItalyDepartment of Human Neurosciences, Sapienza University of Rome, Rome, ItalyNeuromed Institute IRCCS, Pozzilli, ItalyDepartment of Human Neurosciences, Sapienza University of Rome, Rome, ItalyUnit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, University Campus Bio-Medico, Rome, ItalyNuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UKNeuromed Institute IRCCS, Pozzilli, ItalyTranscranial alternating current stimulation (tACS) is a noninvasive neurophysiological technique that can entrain brain oscillations. Only few studies have investigated the effects of tACS on voluntary movements. We aimed to verify whether tACS, delivered over M1 at beta and gamma frequencies, has any effect on repetitive finger tapping as assessed by means of kinematic analysis. Eighteen healthy subjects were enrolled. Objective measurements of repetitive finger tapping were obtained by using a motion analysis system. M1 excitability was assessed by using single-pulse TMS and measuring the amplitude of motor-evoked potentials (MEPs). Movement kinematic measures and MEPs were collected during beta, gamma, and sham tACS and when the stimulation was off. Beta tACS led to an amplitude decrement (i.e., progressive reduction in amplitude) across the first ten movements of the motor sequence while gamma tACS had the opposite effect. The results did not reveal any significant effect of tACS on other movement parameters, nor any changes in MEPs. These findings demonstrate that tACS modulates finger tapping in a frequency-dependent manner with no concurrent changes in corticospinal excitability. The results suggest that cortical beta and gamma oscillations are involved in the motor control of repetitive finger movements.http://dx.doi.org/10.1155/2018/4593095 |
| spellingShingle | Andrea Guerra Matteo Bologna Giulia Paparella Antonio Suppa Donato Colella Vincenzo Di Lazzaro Peter Brown Alfredo Berardelli Effects of Transcranial Alternating Current Stimulation on Repetitive Finger Movements in Healthy Humans Neural Plasticity |
| title | Effects of Transcranial Alternating Current Stimulation on Repetitive Finger Movements in Healthy Humans |
| title_full | Effects of Transcranial Alternating Current Stimulation on Repetitive Finger Movements in Healthy Humans |
| title_fullStr | Effects of Transcranial Alternating Current Stimulation on Repetitive Finger Movements in Healthy Humans |
| title_full_unstemmed | Effects of Transcranial Alternating Current Stimulation on Repetitive Finger Movements in Healthy Humans |
| title_short | Effects of Transcranial Alternating Current Stimulation on Repetitive Finger Movements in Healthy Humans |
| title_sort | effects of transcranial alternating current stimulation on repetitive finger movements in healthy humans |
| url | http://dx.doi.org/10.1155/2018/4593095 |
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