Transition from Intravenous Epoprostenol to Oral or Subcutaneous Therapy in Pulmonary Arterial Hypertension: A Retrospective Case Series and Systematic Literature Review
BACKGROUND: Intravenous epoprostenol, a prostaglandin analogue, has been a mainstay of therapy for patients with advanced pulmonary arterial hypertension (PAH) since the early 1990s. This medication has multiple side effects, and sudden discontinuation is potentially associated with severe sequelae....
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2011/104834 |
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| _version_ | 1832567802543734784 |
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| author | Kirily Park David Ostrow Robert D Levy John Swiston |
| author_facet | Kirily Park David Ostrow Robert D Levy John Swiston |
| author_sort | Kirily Park |
| collection | DOAJ |
| description | BACKGROUND: Intravenous epoprostenol, a prostaglandin analogue, has been a mainstay of therapy for patients with advanced pulmonary arterial hypertension (PAH) since the early 1990s. This medication has multiple side effects, and sudden discontinuation is potentially associated with severe sequelae. Several recent case series have described the transition from intravenous to newer oral or subcutaneous therapies. A case series detailing the authors’ experience with such transitions, and a systematic lierature review is presented. |
| format | Article |
| id | doaj-art-7979622deddc49d3aab4dce0617cbf21 |
| institution | Kabale University |
| issn | 1198-2241 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-7979622deddc49d3aab4dce0617cbf212025-02-03T01:00:35ZengWileyCanadian Respiratory Journal1198-22412011-01-0118315716210.1155/2011/104834Transition from Intravenous Epoprostenol to Oral or Subcutaneous Therapy in Pulmonary Arterial Hypertension: A Retrospective Case Series and Systematic Literature ReviewKirily Park0David Ostrow1Robert D Levy2John Swiston3The Lung Centre, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, CanadaThe Lung Centre, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, CanadaThe Lung Centre, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, CanadaThe Lung Centre, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, CanadaBACKGROUND: Intravenous epoprostenol, a prostaglandin analogue, has been a mainstay of therapy for patients with advanced pulmonary arterial hypertension (PAH) since the early 1990s. This medication has multiple side effects, and sudden discontinuation is potentially associated with severe sequelae. Several recent case series have described the transition from intravenous to newer oral or subcutaneous therapies. A case series detailing the authors’ experience with such transitions, and a systematic lierature review is presented.http://dx.doi.org/10.1155/2011/104834 |
| spellingShingle | Kirily Park David Ostrow Robert D Levy John Swiston Transition from Intravenous Epoprostenol to Oral or Subcutaneous Therapy in Pulmonary Arterial Hypertension: A Retrospective Case Series and Systematic Literature Review Canadian Respiratory Journal |
| title | Transition from Intravenous Epoprostenol to Oral or Subcutaneous Therapy in Pulmonary Arterial Hypertension: A Retrospective Case Series and Systematic Literature Review |
| title_full | Transition from Intravenous Epoprostenol to Oral or Subcutaneous Therapy in Pulmonary Arterial Hypertension: A Retrospective Case Series and Systematic Literature Review |
| title_fullStr | Transition from Intravenous Epoprostenol to Oral or Subcutaneous Therapy in Pulmonary Arterial Hypertension: A Retrospective Case Series and Systematic Literature Review |
| title_full_unstemmed | Transition from Intravenous Epoprostenol to Oral or Subcutaneous Therapy in Pulmonary Arterial Hypertension: A Retrospective Case Series and Systematic Literature Review |
| title_short | Transition from Intravenous Epoprostenol to Oral or Subcutaneous Therapy in Pulmonary Arterial Hypertension: A Retrospective Case Series and Systematic Literature Review |
| title_sort | transition from intravenous epoprostenol to oral or subcutaneous therapy in pulmonary arterial hypertension a retrospective case series and systematic literature review |
| url | http://dx.doi.org/10.1155/2011/104834 |
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