Corticostriatal Plastic Changes in Experimental L-DOPA-Induced Dyskinesia
In Parkinson’s disease (PD), alteration of dopamine- (DA-) dependent striatal functions and pulsatile stimulation of DA receptors caused by the discontinuous administration of levodopa (L-DOPA) lead to a complex cascade of events affecting the postsynaptic striatal neurons that might account for the...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2012/358176 |
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| _version_ | 1832562612216266752 |
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| author | Veronica Ghiglieri Vincenza Bagetta Valentina Pendolino Barbara Picconi Paolo Calabresi |
| author_facet | Veronica Ghiglieri Vincenza Bagetta Valentina Pendolino Barbara Picconi Paolo Calabresi |
| author_sort | Veronica Ghiglieri |
| collection | DOAJ |
| description | In Parkinson’s disease (PD), alteration of dopamine- (DA-) dependent striatal functions and pulsatile stimulation of DA receptors caused by the discontinuous administration of levodopa (L-DOPA) lead to a complex cascade of events affecting the postsynaptic striatal neurons that might account for the appearance of L-DOPA-induced dyskinesia (LID). Experimental models of LID have been widely used and extensively characterized in rodents and electrophysiological studies provided remarkable insights into the inner mechanisms underlying L-DOPA-induced corticostriatal plastic changes. Here we provide an overview of recent findings that represent a further step into the comprehension of mechanisms underlying maladaptive changes of basal ganglia functions in response to L-DOPA and associated to development of LID. |
| format | Article |
| id | doaj-art-7973786e64b248b096cc08c3bca2f664 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-7973786e64b248b096cc08c3bca2f6642025-02-03T01:22:19ZengWileyParkinson's Disease2090-80832042-00802012-01-01201210.1155/2012/358176358176Corticostriatal Plastic Changes in Experimental L-DOPA-Induced DyskinesiaVeronica Ghiglieri0Vincenza Bagetta1Valentina Pendolino2Barbara Picconi3Paolo Calabresi4Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS, Via del Fosso di Fiorano 64, 00143 Rome, ItalyLaboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS, Via del Fosso di Fiorano 64, 00143 Rome, ItalyLaboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS, Via del Fosso di Fiorano 64, 00143 Rome, ItalyLaboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS, Via del Fosso di Fiorano 64, 00143 Rome, ItalyLaboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS, Via del Fosso di Fiorano 64, 00143 Rome, ItalyIn Parkinson’s disease (PD), alteration of dopamine- (DA-) dependent striatal functions and pulsatile stimulation of DA receptors caused by the discontinuous administration of levodopa (L-DOPA) lead to a complex cascade of events affecting the postsynaptic striatal neurons that might account for the appearance of L-DOPA-induced dyskinesia (LID). Experimental models of LID have been widely used and extensively characterized in rodents and electrophysiological studies provided remarkable insights into the inner mechanisms underlying L-DOPA-induced corticostriatal plastic changes. Here we provide an overview of recent findings that represent a further step into the comprehension of mechanisms underlying maladaptive changes of basal ganglia functions in response to L-DOPA and associated to development of LID.http://dx.doi.org/10.1155/2012/358176 |
| spellingShingle | Veronica Ghiglieri Vincenza Bagetta Valentina Pendolino Barbara Picconi Paolo Calabresi Corticostriatal Plastic Changes in Experimental L-DOPA-Induced Dyskinesia Parkinson's Disease |
| title | Corticostriatal Plastic Changes in Experimental L-DOPA-Induced Dyskinesia |
| title_full | Corticostriatal Plastic Changes in Experimental L-DOPA-Induced Dyskinesia |
| title_fullStr | Corticostriatal Plastic Changes in Experimental L-DOPA-Induced Dyskinesia |
| title_full_unstemmed | Corticostriatal Plastic Changes in Experimental L-DOPA-Induced Dyskinesia |
| title_short | Corticostriatal Plastic Changes in Experimental L-DOPA-Induced Dyskinesia |
| title_sort | corticostriatal plastic changes in experimental l dopa induced dyskinesia |
| url | http://dx.doi.org/10.1155/2012/358176 |
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