Diagnostic Challenges of Helicobacter pylori Infection in Ethiopia: A Community-Based Cross-Sectional Study
Background. In resource-constrained countries, accurate diagnosis of Helicobacter pylori infection remains a challenge. This study aimed to assess the clinical utility of locally available serological and stool antigen test kits in the management of people with suspected H. pylori infection in Ethio...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2022/4013020 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552925979738112 |
|---|---|
| author | Esayas Kebede Gudina Hiwot Amare Solomon Ali Melkamu Berhane Arefayine Dagmawi Tewolde Million Tesfaye Eshete Mulusew Gerbaba Jebena Andreas Wieser Guenter Froeschl Markos Tesfaye Hailemichael Desalegn Mulatu Gashaw |
| author_facet | Esayas Kebede Gudina Hiwot Amare Solomon Ali Melkamu Berhane Arefayine Dagmawi Tewolde Million Tesfaye Eshete Mulusew Gerbaba Jebena Andreas Wieser Guenter Froeschl Markos Tesfaye Hailemichael Desalegn Mulatu Gashaw |
| author_sort | Esayas Kebede Gudina |
| collection | DOAJ |
| description | Background. In resource-constrained countries, accurate diagnosis of Helicobacter pylori infection remains a challenge. This study aimed to assess the clinical utility of locally available serological and stool antigen test kits in the management of people with suspected H. pylori infection in Ethiopia. Methods. A community-based cross-sectional study was conducted with apparently healthy adults and children living in southwest Ethiopia. Participants were interviewed for dyspepsia symptoms and related clinical conditions. H. pylori infection was examined using commercially available serological and stool antigen tests. The association between H. pylori tests and dyspepsia symptoms was analyzed using logistic regression models. Results. Out of 1392 participants included in the final analysis, 49.1% and 6.5% tested positive for H. pylori infection with serology and stool antigen test kits, respectively. Participants reporting epigastric symptoms in the past three months (AOR = 1.93, 95% CI = 1.28–2.91) and those with recent dyspepsia treatment (AOR = 1.51, 95% CI = 1.05–2.18) were likely to have positive serology test. However, no association between dyspepsia symptoms and H. pylori stool antigen positivity was observed in our study. Conclusion. ccurate detection of H. pylori infections using commercially accessible diagnostics remains difficult in Ethiopia. With these methods, it will be hard to ensure adequate diagnosis and early treatment of H. pylori infection, as well as rational antibiotic use. |
| format | Article |
| id | doaj-art-796f01aaeedc44789ee56e857ab087ef |
| institution | Kabale University |
| issn | 2291-2797 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-796f01aaeedc44789ee56e857ab087ef2025-02-03T05:57:31ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27972022-01-01202210.1155/2022/4013020Diagnostic Challenges of Helicobacter pylori Infection in Ethiopia: A Community-Based Cross-Sectional StudyEsayas Kebede Gudina0Hiwot Amare1Solomon Ali2Melkamu Berhane Arefayine3Dagmawi Tewolde4Million Tesfaye Eshete5Mulusew Gerbaba Jebena6Andreas Wieser7Guenter Froeschl8Markos Tesfaye9Hailemichael Desalegn10Mulatu Gashaw11Department of Internal MedicineDepartment of Internal MedicineDepartment of MicrobiologyDepartment of PediatricsDepartment of Internal MedicineDepartment of AnesthesiologyDepartment of EpidemiologyDivision of Infectious Diseases and Tropical MedicineDivision of Infectious Diseases and Tropical MedicineDepartment of PsychiatryDepartment of Internal MedicineSchool of Medical Laboratory SciencesBackground. In resource-constrained countries, accurate diagnosis of Helicobacter pylori infection remains a challenge. This study aimed to assess the clinical utility of locally available serological and stool antigen test kits in the management of people with suspected H. pylori infection in Ethiopia. Methods. A community-based cross-sectional study was conducted with apparently healthy adults and children living in southwest Ethiopia. Participants were interviewed for dyspepsia symptoms and related clinical conditions. H. pylori infection was examined using commercially available serological and stool antigen tests. The association between H. pylori tests and dyspepsia symptoms was analyzed using logistic regression models. Results. Out of 1392 participants included in the final analysis, 49.1% and 6.5% tested positive for H. pylori infection with serology and stool antigen test kits, respectively. Participants reporting epigastric symptoms in the past three months (AOR = 1.93, 95% CI = 1.28–2.91) and those with recent dyspepsia treatment (AOR = 1.51, 95% CI = 1.05–2.18) were likely to have positive serology test. However, no association between dyspepsia symptoms and H. pylori stool antigen positivity was observed in our study. Conclusion. ccurate detection of H. pylori infections using commercially accessible diagnostics remains difficult in Ethiopia. With these methods, it will be hard to ensure adequate diagnosis and early treatment of H. pylori infection, as well as rational antibiotic use.http://dx.doi.org/10.1155/2022/4013020 |
| spellingShingle | Esayas Kebede Gudina Hiwot Amare Solomon Ali Melkamu Berhane Arefayine Dagmawi Tewolde Million Tesfaye Eshete Mulusew Gerbaba Jebena Andreas Wieser Guenter Froeschl Markos Tesfaye Hailemichael Desalegn Mulatu Gashaw Diagnostic Challenges of Helicobacter pylori Infection in Ethiopia: A Community-Based Cross-Sectional Study Canadian Journal of Gastroenterology and Hepatology |
| title | Diagnostic Challenges of Helicobacter pylori Infection in Ethiopia: A Community-Based Cross-Sectional Study |
| title_full | Diagnostic Challenges of Helicobacter pylori Infection in Ethiopia: A Community-Based Cross-Sectional Study |
| title_fullStr | Diagnostic Challenges of Helicobacter pylori Infection in Ethiopia: A Community-Based Cross-Sectional Study |
| title_full_unstemmed | Diagnostic Challenges of Helicobacter pylori Infection in Ethiopia: A Community-Based Cross-Sectional Study |
| title_short | Diagnostic Challenges of Helicobacter pylori Infection in Ethiopia: A Community-Based Cross-Sectional Study |
| title_sort | diagnostic challenges of helicobacter pylori infection in ethiopia a community based cross sectional study |
| url | http://dx.doi.org/10.1155/2022/4013020 |
| work_keys_str_mv | AT esayaskebedegudina diagnosticchallengesofhelicobacterpyloriinfectioninethiopiaacommunitybasedcrosssectionalstudy AT hiwotamare diagnosticchallengesofhelicobacterpyloriinfectioninethiopiaacommunitybasedcrosssectionalstudy AT solomonali diagnosticchallengesofhelicobacterpyloriinfectioninethiopiaacommunitybasedcrosssectionalstudy AT melkamuberhanearefayine diagnosticchallengesofhelicobacterpyloriinfectioninethiopiaacommunitybasedcrosssectionalstudy AT dagmawitewolde diagnosticchallengesofhelicobacterpyloriinfectioninethiopiaacommunitybasedcrosssectionalstudy AT milliontesfayeeshete diagnosticchallengesofhelicobacterpyloriinfectioninethiopiaacommunitybasedcrosssectionalstudy AT mulusewgerbabajebena diagnosticchallengesofhelicobacterpyloriinfectioninethiopiaacommunitybasedcrosssectionalstudy AT andreaswieser diagnosticchallengesofhelicobacterpyloriinfectioninethiopiaacommunitybasedcrosssectionalstudy AT guenterfroeschl diagnosticchallengesofhelicobacterpyloriinfectioninethiopiaacommunitybasedcrosssectionalstudy AT markostesfaye diagnosticchallengesofhelicobacterpyloriinfectioninethiopiaacommunitybasedcrosssectionalstudy AT hailemichaeldesalegn diagnosticchallengesofhelicobacterpyloriinfectioninethiopiaacommunitybasedcrosssectionalstudy AT mulatugashaw diagnosticchallengesofhelicobacterpyloriinfectioninethiopiaacommunitybasedcrosssectionalstudy |