Interfacing exogenous stents with human coronary artery by self-assembled coating: designs, functionalities and applications
Abstract Drug-eluting stents are a commonly used treatment for coronary artery disease. However, the coatings used in drug-eluting stents have some limitations such as poor biocompatibility and drug loading capacity. In recent years, self-assembly methods have emerged as a promising alternative for...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-05-01
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| Series: | NPG Asia Materials |
| Online Access: | https://doi.org/10.1038/s41427-024-00548-6 |
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| author | Feng Zhao Feng Liu Chenglong Gao Guoqing Wang Yinfeng Zhang Fei Yu Jiawei Tian Kai Tan Runhao Zhang Kang Liang Zhexun Lian Junjie Guo Biao Kong Junbo Ge Hui Xin |
| author_facet | Feng Zhao Feng Liu Chenglong Gao Guoqing Wang Yinfeng Zhang Fei Yu Jiawei Tian Kai Tan Runhao Zhang Kang Liang Zhexun Lian Junjie Guo Biao Kong Junbo Ge Hui Xin |
| author_sort | Feng Zhao |
| collection | DOAJ |
| description | Abstract Drug-eluting stents are a commonly used treatment for coronary artery disease. However, the coatings used in drug-eluting stents have some limitations such as poor biocompatibility and drug loading capacity. In recent years, self-assembly methods have emerged as a promising alternative for stent coatings. Self-assembled coatings employ biomaterials and offer several advantages over traditional coatings, including thinner thickness, stronger binding capacity, and better biocompatibility. This review discusses the latest research on self-assembled biomaterial-based coatings for drug-eluting stents. We explore how layer-by-layer coatings and composite coating films have been utilized to load and release drugs with high drug loading capacity and biocompatibility, as well as how they promote endothelial adhesion and growth. Additionally, we examine how self-assembled coatings have been used to release active molecules for anti-coagulation and deliver gene therapy. Moreover, we discuss the potential of self-assembled coatings for future development, including intelligent targeted drug delivery, bionic stent coatings, and 3D printed stent coatings. These advancements have the potential to further improve the effectiveness of drug-eluting stents in treating coronary artery disease. |
| format | Article |
| id | doaj-art-795e642c18d242c4a1ac80d4a9aed262 |
| institution | Kabale University |
| issn | 1884-4057 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | NPG Asia Materials |
| spelling | doaj-art-795e642c18d242c4a1ac80d4a9aed2622025-01-19T12:28:57ZengNature PortfolioNPG Asia Materials1884-40572024-05-0116112610.1038/s41427-024-00548-6Interfacing exogenous stents with human coronary artery by self-assembled coating: designs, functionalities and applicationsFeng Zhao0Feng Liu1Chenglong Gao2Guoqing Wang3Yinfeng Zhang4Fei Yu5Jiawei Tian6Kai Tan7Runhao Zhang8Kang Liang9Zhexun Lian10Junjie Guo11Biao Kong12Junbo Ge13Hui Xin14Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao UniversityCollege of Food Science and Engineering, Ocean University of ChinaDepartment of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao UniversityCollege of Food Science and Engineering, Ocean University of ChinaInstitute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao UniversityInstitute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao UniversityDepartment of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao UniversityDepartment of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao UniversityDepartment of Chemistry, Shanghai Key Lab of Molecular Catalysis and Innovative Materials, iChEM, Fudan UniversitySchool of Chemical Engineering and Graduate School of Biomedical Engineering, The University of New South WalesDepartment of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao UniversityDepartment of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao UniversityDepartment of Chemistry, Shanghai Key Lab of Molecular Catalysis and Innovative Materials, iChEM, Fudan UniversityDepartment of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao UniversityDepartment of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao UniversityAbstract Drug-eluting stents are a commonly used treatment for coronary artery disease. However, the coatings used in drug-eluting stents have some limitations such as poor biocompatibility and drug loading capacity. In recent years, self-assembly methods have emerged as a promising alternative for stent coatings. Self-assembled coatings employ biomaterials and offer several advantages over traditional coatings, including thinner thickness, stronger binding capacity, and better biocompatibility. This review discusses the latest research on self-assembled biomaterial-based coatings for drug-eluting stents. We explore how layer-by-layer coatings and composite coating films have been utilized to load and release drugs with high drug loading capacity and biocompatibility, as well as how they promote endothelial adhesion and growth. Additionally, we examine how self-assembled coatings have been used to release active molecules for anti-coagulation and deliver gene therapy. Moreover, we discuss the potential of self-assembled coatings for future development, including intelligent targeted drug delivery, bionic stent coatings, and 3D printed stent coatings. These advancements have the potential to further improve the effectiveness of drug-eluting stents in treating coronary artery disease.https://doi.org/10.1038/s41427-024-00548-6 |
| spellingShingle | Feng Zhao Feng Liu Chenglong Gao Guoqing Wang Yinfeng Zhang Fei Yu Jiawei Tian Kai Tan Runhao Zhang Kang Liang Zhexun Lian Junjie Guo Biao Kong Junbo Ge Hui Xin Interfacing exogenous stents with human coronary artery by self-assembled coating: designs, functionalities and applications NPG Asia Materials |
| title | Interfacing exogenous stents with human coronary artery by self-assembled coating: designs, functionalities and applications |
| title_full | Interfacing exogenous stents with human coronary artery by self-assembled coating: designs, functionalities and applications |
| title_fullStr | Interfacing exogenous stents with human coronary artery by self-assembled coating: designs, functionalities and applications |
| title_full_unstemmed | Interfacing exogenous stents with human coronary artery by self-assembled coating: designs, functionalities and applications |
| title_short | Interfacing exogenous stents with human coronary artery by self-assembled coating: designs, functionalities and applications |
| title_sort | interfacing exogenous stents with human coronary artery by self assembled coating designs functionalities and applications |
| url | https://doi.org/10.1038/s41427-024-00548-6 |
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