COVID-19 among staff and their family members of a healthcare research institution in Bangladesh between March 2020 and April 2021: a test-negative case–control study
Objective To identify factors associated with COVID-19 positivity among staff and their family members of icddr,b, a health research institute located in Bangladesh.Setting Dhaka, Bangladesh.Participants A total of 4295 symptomatic people were tested for SARS-CoV-2 by reverse-transcription PCR betwe...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/6/e058074.full |
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| author | Subhasish Das Mustafa Mahfuz Shah Mohammad Fahim Tahmeed Ahmed Shams E Arifeen Md Ashraful Alam Mustafizur Rahman John D Clemens S M Tafsir Hasan Ishita Mostafa Monira Sarmin Shahana Parveen |
| author_facet | Subhasish Das Mustafa Mahfuz Shah Mohammad Fahim Tahmeed Ahmed Shams E Arifeen Md Ashraful Alam Mustafizur Rahman John D Clemens S M Tafsir Hasan Ishita Mostafa Monira Sarmin Shahana Parveen |
| author_sort | Subhasish Das |
| collection | DOAJ |
| description | Objective To identify factors associated with COVID-19 positivity among staff and their family members of icddr,b, a health research institute located in Bangladesh.Setting Dhaka, Bangladesh.Participants A total of 4295 symptomatic people were tested for SARS-CoV-2 by reverse-transcription PCR between 19 March 2020 and 15 April 2021. Multivariable logistic regression was done to identify the factors associated with COVID-19 positivity by contrasting test positives with test negatives.Result Forty-three per cent of the participants were tested positive for SARS-CoV-2. The median age was high in positive cases (37 years vs 34 years). Among the positive cases, 97% were recovered, 2.1% had reinfections, 24 died and 41 were active cases as of 15 April 2021. Multivariable regression analysis showed that age more than 60 years (adjusted OR (aOR)=2.1, 95% CI 1.3 to 3.3; p<0.05), blood group AB (aOR=1.5, 95% CI 1.1 to 2; p<0.05), fever (aOR=3.1, 95% CI 2.6 to 3.7; p<0.05), cough (aOR=1.3, 95% CI 1.1 to 1.6; p<0.05) and anosmia (aOR=2.7, 95% CI 1.3 to 5.7; p<0.05) were significantly associated with higher odds of being COVID-19 positive when compared with participants who were tested negative.Conclusions The study findings suggest that older age, fever, cough and anosmia were associated with COVID-19 among the study participants. |
| format | Article |
| id | doaj-art-7956081136f74f7791e9284e9f414c31 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-7956081136f74f7791e9284e9f414c312025-01-28T01:05:14ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2021-058074COVID-19 among staff and their family members of a healthcare research institution in Bangladesh between March 2020 and April 2021: a test-negative case–control studySubhasish Das0Mustafa Mahfuz1Shah Mohammad Fahim2Tahmeed Ahmed3Shams E Arifeen4Md Ashraful Alam5Mustafizur Rahman6John D Clemens7S M Tafsir Hasan8Ishita Mostafa9Monira Sarmin10Shahana Parveen11Liggins Institute, University of Auckland, Auckland, New ZealandNutrition and Clinical Services Division (NCSD), International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka, BangladeshNutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, BangladeshNutrition Research Division, International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka, BangladeshMaternal and Child Health Division (MCHD), International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, BangladeshThe University of Queensland Poche Centre for Indigenous Health, Saint Lucia, Queensland, AustraliaInfectious Disease Division, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, BangladeshInfectious Diseases Division, International Centre for Diarrhoeal Disease Research, Dhaka, BangladeshNutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, BangladeshNutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, BangladeshNutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research,Bangladesh (icddr,b), Dhaka, BangladeshStaff Clinic, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, BangladeshObjective To identify factors associated with COVID-19 positivity among staff and their family members of icddr,b, a health research institute located in Bangladesh.Setting Dhaka, Bangladesh.Participants A total of 4295 symptomatic people were tested for SARS-CoV-2 by reverse-transcription PCR between 19 March 2020 and 15 April 2021. Multivariable logistic regression was done to identify the factors associated with COVID-19 positivity by contrasting test positives with test negatives.Result Forty-three per cent of the participants were tested positive for SARS-CoV-2. The median age was high in positive cases (37 years vs 34 years). Among the positive cases, 97% were recovered, 2.1% had reinfections, 24 died and 41 were active cases as of 15 April 2021. Multivariable regression analysis showed that age more than 60 years (adjusted OR (aOR)=2.1, 95% CI 1.3 to 3.3; p<0.05), blood group AB (aOR=1.5, 95% CI 1.1 to 2; p<0.05), fever (aOR=3.1, 95% CI 2.6 to 3.7; p<0.05), cough (aOR=1.3, 95% CI 1.1 to 1.6; p<0.05) and anosmia (aOR=2.7, 95% CI 1.3 to 5.7; p<0.05) were significantly associated with higher odds of being COVID-19 positive when compared with participants who were tested negative.Conclusions The study findings suggest that older age, fever, cough and anosmia were associated with COVID-19 among the study participants.https://bmjopen.bmj.com/content/12/6/e058074.full |
| spellingShingle | Subhasish Das Mustafa Mahfuz Shah Mohammad Fahim Tahmeed Ahmed Shams E Arifeen Md Ashraful Alam Mustafizur Rahman John D Clemens S M Tafsir Hasan Ishita Mostafa Monira Sarmin Shahana Parveen COVID-19 among staff and their family members of a healthcare research institution in Bangladesh between March 2020 and April 2021: a test-negative case–control study BMJ Open |
| title | COVID-19 among staff and their family members of a healthcare research institution in Bangladesh between March 2020 and April 2021: a test-negative case–control study |
| title_full | COVID-19 among staff and their family members of a healthcare research institution in Bangladesh between March 2020 and April 2021: a test-negative case–control study |
| title_fullStr | COVID-19 among staff and their family members of a healthcare research institution in Bangladesh between March 2020 and April 2021: a test-negative case–control study |
| title_full_unstemmed | COVID-19 among staff and their family members of a healthcare research institution in Bangladesh between March 2020 and April 2021: a test-negative case–control study |
| title_short | COVID-19 among staff and their family members of a healthcare research institution in Bangladesh between March 2020 and April 2021: a test-negative case–control study |
| title_sort | covid 19 among staff and their family members of a healthcare research institution in bangladesh between march 2020 and april 2021 a test negative case control study |
| url | https://bmjopen.bmj.com/content/12/6/e058074.full |
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