Multiscale Modeling Indicates That Temperature Dependent [Ca2+]i Spiking in Astrocytes Is Quantitatively Consistent with Modulated SERCA Activity
Changes in the cytosolic Ca2+ concentration ([Ca2+]i) are the most predominant active signaling mechanism in astrocytes that can modulate neuronal activity and is assumed to influence neuronal plasticity. Although Ca2+ signaling in astrocytes has been intensively studied in the past, our understandi...
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Main Authors: | Niko Komin, Mahsa Moein, Mark H. Ellisman, Alexander Skupin |
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Format: | Article |
Language: | English |
Published: |
Wiley
2015-01-01
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Series: | Neural Plasticity |
Online Access: | http://dx.doi.org/10.1155/2015/683490 |
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