Time to Exhale: Additional Value of Expiratory Chest CT in Chronic Obstructive Pulmonary Disease
Objectives. Diagnostic guidelines for chronic obstructive pulmonary disease (COPD) are based on spirometry and clinical criteria. However, this does not address the pathophysiological complexity of the disease sufficiently. Until now, inspiratory chest computed tomography (CT) has been considered as...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2018/9493504 |
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| author | Joshua Gawlitza Frederik Trinkmann Hans Scheffel Andreas Fischer John W. Nance Claudia Henzler Nils Vogler Joachim Saur Ibrahim Akin Martin Borggrefe Stefan O. Schoenberg Thomas Henzler |
| author_facet | Joshua Gawlitza Frederik Trinkmann Hans Scheffel Andreas Fischer John W. Nance Claudia Henzler Nils Vogler Joachim Saur Ibrahim Akin Martin Borggrefe Stefan O. Schoenberg Thomas Henzler |
| author_sort | Joshua Gawlitza |
| collection | DOAJ |
| description | Objectives. Diagnostic guidelines for chronic obstructive pulmonary disease (COPD) are based on spirometry and clinical criteria. However, this does not address the pathophysiological complexity of the disease sufficiently. Until now, inspiratory chest computed tomography (CT) has been considered as the preferred imaging method in these patients. We hypothesized that expiratory CT may be superior to demonstrate pathophysiological changes. The aim of this prospective study was to systematically compare lung function tests with quantified CT parameters in inspiration and expiration. Materials and Methods. Forty-six patients with diagnosed COPD underwent spirometry, body plethysmography, and dose-optimized CT in maximal inspiration and expiration. Four quantified CT parameters were acquired in inspiration, expiration, and their calculated delta values. These parameters were correlated with seven established lung function parameters. Results. For inspiratory scans, a weak-to-moderate correlation with the lung function parameters was found. These correlations significantly improved when adding the expiratory scan (p<0.05). Moreover, some parameters showed a significant correlation only in expiratory datasets. Calculated delta values showed even stronger correlation with lung function testing. Conclusions. Expiratory quantified CT and calculated delta values significantly improve the correlation with lung function parameters. Thus, an additional expiratory CT may improve image-based phenotyping of patients with COPD. |
| format | Article |
| id | doaj-art-793bcb0cca1e49f7ac55cb197cd8f01f |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-793bcb0cca1e49f7ac55cb197cd8f01f2025-02-03T06:05:38ZengWileyCanadian Respiratory Journal1198-22411916-72452018-01-01201810.1155/2018/94935049493504Time to Exhale: Additional Value of Expiratory Chest CT in Chronic Obstructive Pulmonary DiseaseJoshua Gawlitza0Frederik Trinkmann1Hans Scheffel2Andreas Fischer3John W. Nance4Claudia Henzler5Nils Vogler6Joachim Saur7Ibrahim Akin8Martin Borggrefe9Stefan O. Schoenberg10Thomas Henzler11Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, GermanyDepartment of Medicine (Cardiology, Angiology, Pulmonary, and Intensive Care), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, GermanyInstitute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, GermanyInstitute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, GermanyDepartment of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USAInstitute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, GermanyInstitute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, GermanyDepartment of Medicine (Cardiology, Angiology, Pulmonary, and Intensive Care), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, GermanyDepartment of Medicine (Cardiology, Angiology, Pulmonary, and Intensive Care), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, GermanyDepartment of Medicine (Cardiology, Angiology, Pulmonary, and Intensive Care), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, GermanyInstitute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, GermanyInstitute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, GermanyObjectives. Diagnostic guidelines for chronic obstructive pulmonary disease (COPD) are based on spirometry and clinical criteria. However, this does not address the pathophysiological complexity of the disease sufficiently. Until now, inspiratory chest computed tomography (CT) has been considered as the preferred imaging method in these patients. We hypothesized that expiratory CT may be superior to demonstrate pathophysiological changes. The aim of this prospective study was to systematically compare lung function tests with quantified CT parameters in inspiration and expiration. Materials and Methods. Forty-six patients with diagnosed COPD underwent spirometry, body plethysmography, and dose-optimized CT in maximal inspiration and expiration. Four quantified CT parameters were acquired in inspiration, expiration, and their calculated delta values. These parameters were correlated with seven established lung function parameters. Results. For inspiratory scans, a weak-to-moderate correlation with the lung function parameters was found. These correlations significantly improved when adding the expiratory scan (p<0.05). Moreover, some parameters showed a significant correlation only in expiratory datasets. Calculated delta values showed even stronger correlation with lung function testing. Conclusions. Expiratory quantified CT and calculated delta values significantly improve the correlation with lung function parameters. Thus, an additional expiratory CT may improve image-based phenotyping of patients with COPD.http://dx.doi.org/10.1155/2018/9493504 |
| spellingShingle | Joshua Gawlitza Frederik Trinkmann Hans Scheffel Andreas Fischer John W. Nance Claudia Henzler Nils Vogler Joachim Saur Ibrahim Akin Martin Borggrefe Stefan O. Schoenberg Thomas Henzler Time to Exhale: Additional Value of Expiratory Chest CT in Chronic Obstructive Pulmonary Disease Canadian Respiratory Journal |
| title | Time to Exhale: Additional Value of Expiratory Chest CT in Chronic Obstructive Pulmonary Disease |
| title_full | Time to Exhale: Additional Value of Expiratory Chest CT in Chronic Obstructive Pulmonary Disease |
| title_fullStr | Time to Exhale: Additional Value of Expiratory Chest CT in Chronic Obstructive Pulmonary Disease |
| title_full_unstemmed | Time to Exhale: Additional Value of Expiratory Chest CT in Chronic Obstructive Pulmonary Disease |
| title_short | Time to Exhale: Additional Value of Expiratory Chest CT in Chronic Obstructive Pulmonary Disease |
| title_sort | time to exhale additional value of expiratory chest ct in chronic obstructive pulmonary disease |
| url | http://dx.doi.org/10.1155/2018/9493504 |
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