Protection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis
Given the growing evidence of a link between gut microbiota (GM) dysbiosis and multiple sclerosis (MS), fecal microbiota transplantation (FMT), aimed at rebuilding GM, has been proposed as a new therapeutic approach to MS treatment. To evaluate the viability of FMT for MS treatment and its impact on...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/2058272 |
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| _version_ | 1832556822904438784 |
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| author | Kanglan Li Shouchao Wei Li Hu Xiaojian Yin Yingren Mai Chunmei Jiang Xiaoping Peng Xingxing Cao Zhongkai Huang Haihong Zhou Guoda Ma Zhou Liu Huiliang Li Bin Zhao |
| author_facet | Kanglan Li Shouchao Wei Li Hu Xiaojian Yin Yingren Mai Chunmei Jiang Xiaoping Peng Xingxing Cao Zhongkai Huang Haihong Zhou Guoda Ma Zhou Liu Huiliang Li Bin Zhao |
| author_sort | Kanglan Li |
| collection | DOAJ |
| description | Given the growing evidence of a link between gut microbiota (GM) dysbiosis and multiple sclerosis (MS), fecal microbiota transplantation (FMT), aimed at rebuilding GM, has been proposed as a new therapeutic approach to MS treatment. To evaluate the viability of FMT for MS treatment and its impact on MS pathology, we tested FMT in mice with experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. We provide evidence that FMT can rectify altered GM to some extent with a therapeutic effect on EAE. We also found that FMT led to reduced activation of microglia and astrocytes and conferred protection on the blood-brain barrier (BBB), myelin, and axons in EAE. Taken together, our data suggest that FMT, as a GM-based therapy, has the potential to be an effective treatment for MS. |
| format | Article |
| id | doaj-art-79364ce46f8a4a5ba6eb98123b6785df |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-79364ce46f8a4a5ba6eb98123b6785df2025-02-03T05:44:16ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/20582722058272Protection of Fecal Microbiota Transplantation in a Mouse Model of Multiple SclerosisKanglan Li0Shouchao Wei1Li Hu2Xiaojian Yin3Yingren Mai4Chunmei Jiang5Xiaoping Peng6Xingxing Cao7Zhongkai Huang8Haihong Zhou9Guoda Ma10Zhou Liu11Huiliang Li12Bin Zhao13Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, ChinaDepartment of Neurosurgery, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, ChinaGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, ChinaWolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UKGuangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, ChinaGiven the growing evidence of a link between gut microbiota (GM) dysbiosis and multiple sclerosis (MS), fecal microbiota transplantation (FMT), aimed at rebuilding GM, has been proposed as a new therapeutic approach to MS treatment. To evaluate the viability of FMT for MS treatment and its impact on MS pathology, we tested FMT in mice with experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. We provide evidence that FMT can rectify altered GM to some extent with a therapeutic effect on EAE. We also found that FMT led to reduced activation of microglia and astrocytes and conferred protection on the blood-brain barrier (BBB), myelin, and axons in EAE. Taken together, our data suggest that FMT, as a GM-based therapy, has the potential to be an effective treatment for MS.http://dx.doi.org/10.1155/2020/2058272 |
| spellingShingle | Kanglan Li Shouchao Wei Li Hu Xiaojian Yin Yingren Mai Chunmei Jiang Xiaoping Peng Xingxing Cao Zhongkai Huang Haihong Zhou Guoda Ma Zhou Liu Huiliang Li Bin Zhao Protection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis Mediators of Inflammation |
| title | Protection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis |
| title_full | Protection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis |
| title_fullStr | Protection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis |
| title_full_unstemmed | Protection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis |
| title_short | Protection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis |
| title_sort | protection of fecal microbiota transplantation in a mouse model of multiple sclerosis |
| url | http://dx.doi.org/10.1155/2020/2058272 |
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