Lipid Oxidation at the Crossroads: Oxidative Stress and Neurodegeneration Explored in <i>Caenorhabditis elegans</i>
Lipid metabolism plays a critical role in maintaining cellular integrity, especially within the nervous system, where lipids support neuronal structure, function, and synaptic plasticity. However, this essential metabolic pathway is highly susceptible to oxidative stress, which can lead to lipid per...
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2025-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/14/1/78 |
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| author | Julia Tortajada-Pérez Andrea del Valle Carranza Cristina Trujillo-del Río Mar Collado-Pérez José María Millán Gema García-García Rafael Pascual Vázquez-Manrique |
| author_facet | Julia Tortajada-Pérez Andrea del Valle Carranza Cristina Trujillo-del Río Mar Collado-Pérez José María Millán Gema García-García Rafael Pascual Vázquez-Manrique |
| author_sort | Julia Tortajada-Pérez |
| collection | DOAJ |
| description | Lipid metabolism plays a critical role in maintaining cellular integrity, especially within the nervous system, where lipids support neuronal structure, function, and synaptic plasticity. However, this essential metabolic pathway is highly susceptible to oxidative stress, which can lead to lipid peroxidation, a damaging process induced by reactive oxygen species. Lipid peroxidation generates by-products that disrupt many cellular functions, with a strong impact on proteostasis. In this review, we explore the role of lipid oxidation in protein folding and its associated pathological implications, with a particular focus on findings in neurodegeneration from <i>Caenorhabditis elegans</i> studies, an animal model that remains underutilized. Additionally, we highlight the effectiveness of different methodologies applied in this nematode to deepen our understanding of this intricate process. In the nervous system of any animal, including mammals and invertebrates, lipid oxidation can disturb the delicate balance of cellular homeostasis, leading to oxidative stress, the build-up of toxic by-products, and protein misfolding, key factors in neurodegenerative diseases. This disruption contributes to the pathogenesis of neurodegenerative disorders such as Alzheimer’s, Parkinson’s, or Huntington’s disease. The findings from <i>Caenorhabditis elegans</i> studies offer valuable insights into these complex processes and highlight potential avenues for developing targeted therapies to mitigate neurodegenerative disease progression. |
| format | Article |
| id | doaj-art-7932947938544610be0bf96758b63d78 |
| institution | Kabale University |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-7932947938544610be0bf96758b63d782025-01-24T13:19:24ZengMDPI AGAntioxidants2076-39212025-01-011417810.3390/antiox14010078Lipid Oxidation at the Crossroads: Oxidative Stress and Neurodegeneration Explored in <i>Caenorhabditis elegans</i>Julia Tortajada-Pérez0Andrea del Valle Carranza1Cristina Trujillo-del Río2Mar Collado-Pérez3José María Millán4Gema García-García5Rafael Pascual Vázquez-Manrique6Laboratory of Molecular, Cellular and Genomic Biomedicine, Instituto de Investigación Sanitaria La Fe, 46026 Valencia, SpainLaboratory of Molecular, Cellular and Genomic Biomedicine, Instituto de Investigación Sanitaria La Fe, 46026 Valencia, SpainLaboratory of Molecular, Cellular and Genomic Biomedicine, Instituto de Investigación Sanitaria La Fe, 46026 Valencia, SpainLaboratory of Molecular, Cellular and Genomic Biomedicine, Instituto de Investigación Sanitaria La Fe, 46026 Valencia, SpainLaboratory of Molecular, Cellular and Genomic Biomedicine, Instituto de Investigación Sanitaria La Fe, 46026 Valencia, SpainLaboratory of Molecular, Cellular and Genomic Biomedicine, Instituto de Investigación Sanitaria La Fe, 46026 Valencia, SpainLaboratory of Molecular, Cellular and Genomic Biomedicine, Instituto de Investigación Sanitaria La Fe, 46026 Valencia, SpainLipid metabolism plays a critical role in maintaining cellular integrity, especially within the nervous system, where lipids support neuronal structure, function, and synaptic plasticity. However, this essential metabolic pathway is highly susceptible to oxidative stress, which can lead to lipid peroxidation, a damaging process induced by reactive oxygen species. Lipid peroxidation generates by-products that disrupt many cellular functions, with a strong impact on proteostasis. In this review, we explore the role of lipid oxidation in protein folding and its associated pathological implications, with a particular focus on findings in neurodegeneration from <i>Caenorhabditis elegans</i> studies, an animal model that remains underutilized. Additionally, we highlight the effectiveness of different methodologies applied in this nematode to deepen our understanding of this intricate process. In the nervous system of any animal, including mammals and invertebrates, lipid oxidation can disturb the delicate balance of cellular homeostasis, leading to oxidative stress, the build-up of toxic by-products, and protein misfolding, key factors in neurodegenerative diseases. This disruption contributes to the pathogenesis of neurodegenerative disorders such as Alzheimer’s, Parkinson’s, or Huntington’s disease. The findings from <i>Caenorhabditis elegans</i> studies offer valuable insights into these complex processes and highlight potential avenues for developing targeted therapies to mitigate neurodegenerative disease progression.https://www.mdpi.com/2076-3921/14/1/78lipid metabolismlipid oxidationprotein misfoldingneurodegenerative disorders<i>C. elegans</i> |
| spellingShingle | Julia Tortajada-Pérez Andrea del Valle Carranza Cristina Trujillo-del Río Mar Collado-Pérez José María Millán Gema García-García Rafael Pascual Vázquez-Manrique Lipid Oxidation at the Crossroads: Oxidative Stress and Neurodegeneration Explored in <i>Caenorhabditis elegans</i> Antioxidants lipid metabolism lipid oxidation protein misfolding neurodegenerative disorders <i>C. elegans</i> |
| title | Lipid Oxidation at the Crossroads: Oxidative Stress and Neurodegeneration Explored in <i>Caenorhabditis elegans</i> |
| title_full | Lipid Oxidation at the Crossroads: Oxidative Stress and Neurodegeneration Explored in <i>Caenorhabditis elegans</i> |
| title_fullStr | Lipid Oxidation at the Crossroads: Oxidative Stress and Neurodegeneration Explored in <i>Caenorhabditis elegans</i> |
| title_full_unstemmed | Lipid Oxidation at the Crossroads: Oxidative Stress and Neurodegeneration Explored in <i>Caenorhabditis elegans</i> |
| title_short | Lipid Oxidation at the Crossroads: Oxidative Stress and Neurodegeneration Explored in <i>Caenorhabditis elegans</i> |
| title_sort | lipid oxidation at the crossroads oxidative stress and neurodegeneration explored in i caenorhabditis elegans i |
| topic | lipid metabolism lipid oxidation protein misfolding neurodegenerative disorders <i>C. elegans</i> |
| url | https://www.mdpi.com/2076-3921/14/1/78 |
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