New insights into CAR T-cell hematological toxicities: manifestations, mechanisms, and effective management strategies

New insights into CAR T-cell hematological toxicities: manifestations, mechanisms, and effective management strategies

Abstract Chimeric antigen receptor (CAR) T-cell therapy represents a highly efficacious treatment modality demonstrated to enhance outcomes in patients afflicted with malignancies, particularly those enduring relapsed or refractory hematological malignancies. However, the escalating adoption of CAR...

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Bibliographic Details
Main Authors: Yuanyuan Yang, Hongwei Peng, Jianxiang Wang, Fei Li
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Experimental Hematology & Oncology
Subjects:
Chimeric antigen receptor (CAR)
CAR T-cell therapy
Hematological toxicity
Cytopenias
Coagulopathy
HLH
Online Access:https://doi.org/10.1186/s40164-024-00573-9
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