Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled Study
Curcumin, a turmeric extract, may protect against cardiovascular diseases by enhancing endothelial function. In this randomized controlled double-blind parallel prospective study, fifty-nine healthy adults were assigned to placebo, 50 mg (50 mg), or 200 mg (200 mg) curcumin, for 8 weeks. The higher...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2016/1089653 |
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| author | Jonathan M. Oliver Lee Stoner David S. Rowlands Aaron R. Caldwell Elizabeth Sanders Andreas Kreutzer Joel B. Mitchell Martin Purpura Ralf Jäger |
| author_facet | Jonathan M. Oliver Lee Stoner David S. Rowlands Aaron R. Caldwell Elizabeth Sanders Andreas Kreutzer Joel B. Mitchell Martin Purpura Ralf Jäger |
| author_sort | Jonathan M. Oliver |
| collection | DOAJ |
| description | Curcumin, a turmeric extract, may protect against cardiovascular diseases by enhancing endothelial function. In this randomized controlled double-blind parallel prospective study, fifty-nine healthy adults were assigned to placebo, 50 mg (50 mg), or 200 mg (200 mg) curcumin, for 8 weeks. The higher curcumin (200 mg) supplementation produced a dose-mediated improvement in endothelial function measured by flow-mediated dilation (FMD). The outcome was a clinically substantial 3.0% increase (90% CI 0.7 to 5.3%, p=0.032; benefit : harm odds ratio 546 : 1) with the 200 mg dose, relative to placebo. The 50 mg dose also increased FMD relative to placebo by 1.7% (−0.6 to 4.0%, p=0.23; 25 : 1), but the outcome was not clinically decisive. In apparently healthy adults, 8 weeks of 200 mg oral curcumin supplementation resulted in a clinically meaningful improvement in endothelial function as measured by FMD. Oral curcumin supplementation may present a simple lifestyle strategy for decreasing the risk of cardiovascular diseases. This trial was registered at ISRCTN registry (ISRCTN90184217). |
| format | Article |
| id | doaj-art-7927680f4830486484d385864dcfb4b9 |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-7927680f4830486484d385864dcfb4b92025-02-03T06:12:15ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322016-01-01201610.1155/2016/10896531089653Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled StudyJonathan M. Oliver0Lee Stoner1David S. Rowlands2Aaron R. Caldwell3Elizabeth Sanders4Andreas Kreutzer5Joel B. Mitchell6Martin Purpura7Ralf Jäger8Department of Kinesiology, Texas Christian University, TCU Box 297730, Fort Worth, TX 76129, USASchool of Sport and Exercise, Massey University, 63 Wallace Street, Wellington 6021, New ZealandSchool of Sport and Exercise, Massey University, 63 Wallace Street, Wellington 6021, New ZealandDepartment of Kinesiology, Texas Christian University, TCU Box 297730, Fort Worth, TX 76129, USADepartment of Kinesiology, Texas Christian University, TCU Box 297730, Fort Worth, TX 76129, USADepartment of Kinesiology, Texas Christian University, TCU Box 297730, Fort Worth, TX 76129, USADepartment of Kinesiology, Texas Christian University, TCU Box 297730, Fort Worth, TX 76129, USAIncrenovo LLC, 2138 E. Lafayette Place, Milwaukee, WI 53202, USAIncrenovo LLC, 2138 E. Lafayette Place, Milwaukee, WI 53202, USACurcumin, a turmeric extract, may protect against cardiovascular diseases by enhancing endothelial function. In this randomized controlled double-blind parallel prospective study, fifty-nine healthy adults were assigned to placebo, 50 mg (50 mg), or 200 mg (200 mg) curcumin, for 8 weeks. The higher curcumin (200 mg) supplementation produced a dose-mediated improvement in endothelial function measured by flow-mediated dilation (FMD). The outcome was a clinically substantial 3.0% increase (90% CI 0.7 to 5.3%, p=0.032; benefit : harm odds ratio 546 : 1) with the 200 mg dose, relative to placebo. The 50 mg dose also increased FMD relative to placebo by 1.7% (−0.6 to 4.0%, p=0.23; 25 : 1), but the outcome was not clinically decisive. In apparently healthy adults, 8 weeks of 200 mg oral curcumin supplementation resulted in a clinically meaningful improvement in endothelial function as measured by FMD. Oral curcumin supplementation may present a simple lifestyle strategy for decreasing the risk of cardiovascular diseases. This trial was registered at ISRCTN registry (ISRCTN90184217).http://dx.doi.org/10.1155/2016/1089653 |
| spellingShingle | Jonathan M. Oliver Lee Stoner David S. Rowlands Aaron R. Caldwell Elizabeth Sanders Andreas Kreutzer Joel B. Mitchell Martin Purpura Ralf Jäger Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled Study Journal of Nutrition and Metabolism |
| title | Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled Study |
| title_full | Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled Study |
| title_fullStr | Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled Study |
| title_full_unstemmed | Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled Study |
| title_short | Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled Study |
| title_sort | novel form of curcumin improves endothelial function in young healthy individuals a double blind placebo controlled study |
| url | http://dx.doi.org/10.1155/2016/1089653 |
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