Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population: Results from the NORA Study
Background. The present paper described the biological characteristics and clinical behavior of young women in the cohort NORA study Patients and Methods. From 2000–2002, patients (𝑁>3500) were enrolled at 77 Italian hospitals. Women aged ≤50 years (𝑁=1013) were stratified into age groups (≤35...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.4061/2011/534256 |
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| author | P. Pronzato G. Mustacchi A. De Matteis F. Di Costanzo E. Rulli I. Floriani M. E. Cazzaniga |
| author_facet | P. Pronzato G. Mustacchi A. De Matteis F. Di Costanzo E. Rulli I. Floriani M. E. Cazzaniga |
| author_sort | P. Pronzato |
| collection | DOAJ |
| description | Background. The present paper described the biological characteristics and clinical behavior of young women in the cohort NORA study Patients and Methods. From 2000–2002, patients (𝑁>3500) were enrolled at 77 Italian hospitals. Women aged ≤50 years (𝑁=1013) were stratified into age groups (≤35, 36–40, 41–45, and 46–50 years). The relationship between age and patient characteristics, cancer presentation, and treatment was analyzed. Results. Younger women more frequently had tumors with ER/PgR-negative(𝜒2=7.07; 𝑃=.008), HER2 amplification (𝜒2=5.76; 𝑃=.01), and high (≥10%) Ki67 labelling index (𝜒2=9.53; 𝑃=.002). Positive nodal status, large tumors, and elevated Ki67 all associated with the choice for chemotherapy followed by endocrine therapy in hormone receptor-positive patients (𝑃<.0001). At univariate analysis, ER-ve status, chemotherapy and age resulted as the only statistically significant variables (HR=2.02, 𝑃=.004, and >40 versus ≤40, 𝑃<.0001, resp.). At multivariate analysis, after adjustment for significant clinical and pathological factors, age remains a significant prognostic variable (HR=0.93, 𝑃=.0021). Conclusion. This cohort study suggests that age per sè is an important prognostic factor. The restricted role of early diagnosis and the aggressive behavior of cancer in this population make necessary the application of targeted medical strategies crucial. |
| format | Article |
| id | doaj-art-790547fea42149f0b0cb1fc00ff4ab70 |
| institution | Kabale University |
| issn | 2090-3189 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-790547fea42149f0b0cb1fc00ff4ab702025-02-03T05:58:10ZengWileyInternational Journal of Breast Cancer2090-31892011-01-01201110.4061/2011/534256534256Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population: Results from the NORA StudyP. Pronzato0G. Mustacchi1A. De Matteis2F. Di Costanzo3E. Rulli4I. Floriani5M. E. Cazzaniga6Oncologia Medica, IST, Genova 16010, ItalyMedical Oncology Department, University of Trieste, Trieste 34010, ItalyMedical Oncology C, National Cancer Institute, G. Pascale Foundation, Napoli 80010, ItalyMedical Oncology, Careggi University Hospital, Firenze 50012, ItalyOncology Department, Mario Negri Institute for Pharmacological Research, Milano 20100, ItalyOncology Department, Mario Negri Institute for Pharmacological Research, Milano 20100, ItalyMedical Oncology, San Gerardo Hospital, Az Osp San Gerardo, Via Pergolesi 33, 20052 Monza, ItalyBackground. The present paper described the biological characteristics and clinical behavior of young women in the cohort NORA study Patients and Methods. From 2000–2002, patients (𝑁>3500) were enrolled at 77 Italian hospitals. Women aged ≤50 years (𝑁=1013) were stratified into age groups (≤35, 36–40, 41–45, and 46–50 years). The relationship between age and patient characteristics, cancer presentation, and treatment was analyzed. Results. Younger women more frequently had tumors with ER/PgR-negative(𝜒2=7.07; 𝑃=.008), HER2 amplification (𝜒2=5.76; 𝑃=.01), and high (≥10%) Ki67 labelling index (𝜒2=9.53; 𝑃=.002). Positive nodal status, large tumors, and elevated Ki67 all associated with the choice for chemotherapy followed by endocrine therapy in hormone receptor-positive patients (𝑃<.0001). At univariate analysis, ER-ve status, chemotherapy and age resulted as the only statistically significant variables (HR=2.02, 𝑃=.004, and >40 versus ≤40, 𝑃<.0001, resp.). At multivariate analysis, after adjustment for significant clinical and pathological factors, age remains a significant prognostic variable (HR=0.93, 𝑃=.0021). Conclusion. This cohort study suggests that age per sè is an important prognostic factor. The restricted role of early diagnosis and the aggressive behavior of cancer in this population make necessary the application of targeted medical strategies crucial.http://dx.doi.org/10.4061/2011/534256 |
| spellingShingle | P. Pronzato G. Mustacchi A. De Matteis F. Di Costanzo E. Rulli I. Floriani M. E. Cazzaniga Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population: Results from the NORA Study International Journal of Breast Cancer |
| title | Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population: Results from the NORA Study |
| title_full | Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population: Results from the NORA Study |
| title_fullStr | Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population: Results from the NORA Study |
| title_full_unstemmed | Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population: Results from the NORA Study |
| title_short | Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population: Results from the NORA Study |
| title_sort | biological characteristics and medical treatment of breast cancer in young women a featured population results from the nora study |
| url | http://dx.doi.org/10.4061/2011/534256 |
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