Hypovitaminosis D3, Leukopenia, and Human Serotonin Transporter Polymorphism in Anorexia Nervosa and Bulimia Nervosa
Vitamin D3 has been described to have different extraskeletal roles by acting as parahormone in obesity, diabetes, cancer, cognitive impairment, and dementia and to have important regulatory functions in innate immunity. There are no studies showing extraskeletal changes associated with hypovitamino...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/8046479 |
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| author | Anna Tasegian Francesco Curcio Laura Dalla Ragione Francesca Rossetti Samuela Cataldi Michela Codini Francesco Saverio Ambesi-Impiombato Tommaso Beccari Elisabetta Albi |
| author_facet | Anna Tasegian Francesco Curcio Laura Dalla Ragione Francesca Rossetti Samuela Cataldi Michela Codini Francesco Saverio Ambesi-Impiombato Tommaso Beccari Elisabetta Albi |
| author_sort | Anna Tasegian |
| collection | DOAJ |
| description | Vitamin D3 has been described to have different extraskeletal roles by acting as parahormone in obesity, diabetes, cancer, cognitive impairment, and dementia and to have important regulatory functions in innate immunity. There are no studies showing extraskeletal changes associated with hypovitaminosis D3 in eating disorders. Methods. We have analyzed the blood of 18 patients affected by anorexia nervosa and bulimia nervosa collected over a 15-month period. We performed a panel of chemical and clinical analyses: the assay of vitamin D3, the immunoblotting of vitamin D receptor and peroxisome proliferator-activated receptor gamma, and the genotyping of 5-hydroxytryptamine transporter linked polymorphic region. Results. We choose 18 patients with a normal blood test profile such as thyroid hormones, hepatic and renal parameters, triglycerides, proteins, vitamin B12, and folic acid. Among these emerged the case of a woman with long-term anorexia nervosa and the case of a woman with long-term bulimia nervosa both complicated by anxiety and depression, severe hypovitaminosis D3, decrease of vitamin D receptor, leukopenia, and 5-hydroxytryptamine transporter linked polymorphic region short allele. Conclusion. The results induce hypothesising that the severe hypovitaminosis D3 might be responsible for the lack of the inflammatory response and the depressive symptoms in patients with long-term eating disorders. |
| format | Article |
| id | doaj-art-7903dcdf82b74eaf91960bd5406b7d2f |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-7903dcdf82b74eaf91960bd5406b7d2f2025-02-03T01:00:53ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/80464798046479Hypovitaminosis D3, Leukopenia, and Human Serotonin Transporter Polymorphism in Anorexia Nervosa and Bulimia NervosaAnna Tasegian0Francesco Curcio1Laura Dalla Ragione2Francesca Rossetti3Samuela Cataldi4Michela Codini5Francesco Saverio Ambesi-Impiombato6Tommaso Beccari7Elisabetta Albi8Department of Pharmaceutical Sciences, University of Perugia, Via Fabretti No. 48, 06123 Perugia, ItalyDepartment of Clinical and Biological Sciences, University of Udine, Piazzale Kolbe No. 4, 33100 Udine, ItalyDepartment of Eating Disorder, Palazzo Francisci Todi, USL 1 Umbria, Via Cesia No. 65, 06059 Todi, ItalyDepartment of Eating Disorder, Palazzo Francisci Todi, USL 1 Umbria, Via Cesia No. 65, 06059 Todi, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, Via Fabretti No. 48, 06123 Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, Via Fabretti No. 48, 06123 Perugia, ItalyDepartment of Clinical and Biological Sciences, University of Udine, Piazzale Kolbe No. 4, 33100 Udine, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, Via Fabretti No. 48, 06123 Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, Via Fabretti No. 48, 06123 Perugia, ItalyVitamin D3 has been described to have different extraskeletal roles by acting as parahormone in obesity, diabetes, cancer, cognitive impairment, and dementia and to have important regulatory functions in innate immunity. There are no studies showing extraskeletal changes associated with hypovitaminosis D3 in eating disorders. Methods. We have analyzed the blood of 18 patients affected by anorexia nervosa and bulimia nervosa collected over a 15-month period. We performed a panel of chemical and clinical analyses: the assay of vitamin D3, the immunoblotting of vitamin D receptor and peroxisome proliferator-activated receptor gamma, and the genotyping of 5-hydroxytryptamine transporter linked polymorphic region. Results. We choose 18 patients with a normal blood test profile such as thyroid hormones, hepatic and renal parameters, triglycerides, proteins, vitamin B12, and folic acid. Among these emerged the case of a woman with long-term anorexia nervosa and the case of a woman with long-term bulimia nervosa both complicated by anxiety and depression, severe hypovitaminosis D3, decrease of vitamin D receptor, leukopenia, and 5-hydroxytryptamine transporter linked polymorphic region short allele. Conclusion. The results induce hypothesising that the severe hypovitaminosis D3 might be responsible for the lack of the inflammatory response and the depressive symptoms in patients with long-term eating disorders.http://dx.doi.org/10.1155/2016/8046479 |
| spellingShingle | Anna Tasegian Francesco Curcio Laura Dalla Ragione Francesca Rossetti Samuela Cataldi Michela Codini Francesco Saverio Ambesi-Impiombato Tommaso Beccari Elisabetta Albi Hypovitaminosis D3, Leukopenia, and Human Serotonin Transporter Polymorphism in Anorexia Nervosa and Bulimia Nervosa Mediators of Inflammation |
| title | Hypovitaminosis D3, Leukopenia, and Human Serotonin Transporter Polymorphism in Anorexia Nervosa and Bulimia Nervosa |
| title_full | Hypovitaminosis D3, Leukopenia, and Human Serotonin Transporter Polymorphism in Anorexia Nervosa and Bulimia Nervosa |
| title_fullStr | Hypovitaminosis D3, Leukopenia, and Human Serotonin Transporter Polymorphism in Anorexia Nervosa and Bulimia Nervosa |
| title_full_unstemmed | Hypovitaminosis D3, Leukopenia, and Human Serotonin Transporter Polymorphism in Anorexia Nervosa and Bulimia Nervosa |
| title_short | Hypovitaminosis D3, Leukopenia, and Human Serotonin Transporter Polymorphism in Anorexia Nervosa and Bulimia Nervosa |
| title_sort | hypovitaminosis d3 leukopenia and human serotonin transporter polymorphism in anorexia nervosa and bulimia nervosa |
| url | http://dx.doi.org/10.1155/2016/8046479 |
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