Potential Role of Meiosis Proteins in Melanoma Chromosomal Instability
Melanomas demonstrate chromosomal instability (CIN). In fact, CIN can be used to differentiate melanoma from benign nevi. The exact molecular mechanisms that drive CIN in melanoma have yet to be fully elucidated. Cancer/testis antigens are a unique group of germ cell proteins that are found to be pr...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Skin Cancer |
| Online Access: | http://dx.doi.org/10.1155/2013/190109 |
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| _version_ | 1832552649786916864 |
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| author | Scott F. Lindsey Diana M. Byrnes Mark S. Eller Ashley M. Rosa Nitika Dabas Julia Escandon James M. Grichnik |
| author_facet | Scott F. Lindsey Diana M. Byrnes Mark S. Eller Ashley M. Rosa Nitika Dabas Julia Escandon James M. Grichnik |
| author_sort | Scott F. Lindsey |
| collection | DOAJ |
| description | Melanomas demonstrate chromosomal instability (CIN). In fact, CIN can be used to differentiate melanoma from benign nevi. The exact molecular mechanisms that drive CIN in melanoma have yet to be fully elucidated. Cancer/testis antigens are a unique group of germ cell proteins that are found to be primarily expressed in melanoma as compared to benign nevi. The abnormal expression of these germ cell proteins, normally expected only in the testis and ovaries, in somatic cells may lead to interference with normal cellular pathways. Germ cell proteins that may be particularly critical in CIN are meiosis proteins. Here, we review pathways unique to meiosis with a focus on how the aberrant expression of meiosis proteins in normal mitotic cells “meiomitosis” could impact chromosomal instability in melanoma and other cancers. |
| format | Article |
| id | doaj-art-79030c7be53e40ca9e88f2167a82a194 |
| institution | Kabale University |
| issn | 2090-2905 2090-2913 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Skin Cancer |
| spelling | doaj-art-79030c7be53e40ca9e88f2167a82a1942025-02-03T05:58:13ZengWileyJournal of Skin Cancer2090-29052090-29132013-01-01201310.1155/2013/190109190109Potential Role of Meiosis Proteins in Melanoma Chromosomal InstabilityScott F. Lindsey0Diana M. Byrnes1Mark S. Eller2Ashley M. Rosa3Nitika Dabas4Julia Escandon5James M. Grichnik6Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USAMelanomas demonstrate chromosomal instability (CIN). In fact, CIN can be used to differentiate melanoma from benign nevi. The exact molecular mechanisms that drive CIN in melanoma have yet to be fully elucidated. Cancer/testis antigens are a unique group of germ cell proteins that are found to be primarily expressed in melanoma as compared to benign nevi. The abnormal expression of these germ cell proteins, normally expected only in the testis and ovaries, in somatic cells may lead to interference with normal cellular pathways. Germ cell proteins that may be particularly critical in CIN are meiosis proteins. Here, we review pathways unique to meiosis with a focus on how the aberrant expression of meiosis proteins in normal mitotic cells “meiomitosis” could impact chromosomal instability in melanoma and other cancers.http://dx.doi.org/10.1155/2013/190109 |
| spellingShingle | Scott F. Lindsey Diana M. Byrnes Mark S. Eller Ashley M. Rosa Nitika Dabas Julia Escandon James M. Grichnik Potential Role of Meiosis Proteins in Melanoma Chromosomal Instability Journal of Skin Cancer |
| title | Potential Role of Meiosis Proteins in Melanoma Chromosomal Instability |
| title_full | Potential Role of Meiosis Proteins in Melanoma Chromosomal Instability |
| title_fullStr | Potential Role of Meiosis Proteins in Melanoma Chromosomal Instability |
| title_full_unstemmed | Potential Role of Meiosis Proteins in Melanoma Chromosomal Instability |
| title_short | Potential Role of Meiosis Proteins in Melanoma Chromosomal Instability |
| title_sort | potential role of meiosis proteins in melanoma chromosomal instability |
| url | http://dx.doi.org/10.1155/2013/190109 |
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