Efficacy of different preoperative antiseptics in preventing a risk of surgical site infections: a systematic review and meta‑analysis of randomized controlled trials
Introduction: Surgical site infection (SSI) is a predominant postoperative complication that markedly increases health care expenses. Published systematic reviews, meta-analyses and international guidelines vary in their recommendations for the most effective preoperative skin antiseptic solutions a...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2024-07-01
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| Series: | Videosurgery and Other Miniinvasive Techniques |
| Subjects: | |
| Online Access: | https://www.mp.pl/videosurgery/issue/article/17885/ |
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| _version_ | 1832582519858397184 |
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| author | Lutao Yang Shunxin Liao Qing Cao Sanjay Rastogi |
| author_facet | Lutao Yang Shunxin Liao Qing Cao Sanjay Rastogi |
| author_sort | Lutao Yang |
| collection | DOAJ |
| description | Introduction: Surgical site infection (SSI) is a predominant postoperative complication that markedly increases health care expenses. Published systematic reviews, meta-analyses and international guidelines vary in their recommendations for the most effective preoperative skin antiseptic solutions and their concentrations.
Aim: The aim of this study was to assess the efficacy of different preoperative antiseptics for preventing the risk of SSIs.
Materials and methods: A complete search was conducted using PubMed, EMBASE, Scopus, and Cochrane Library databases to collect peer-reviewed articles.
Results: This meta-analysis included 10 587 surgical patients from 18 randomized clinical trials to determine the effectiveness of chlorhexidine in alcohol (CHA; 0.5%, 2%–2.5%, and 4%) with aqueous or alcoholic iodine in preventing postoperative SSIs. This meta-analysis found that 2%–2.5% CHA is the most effective preoperative antiseptic for preventing SSIs, with significant reduction in their incidence and significant antimicrobial activity.
Conclusions: The findings of this meta-analysis indicate that for patients undergoing any type of surgery, the use of 2%–2.5% CHA for skin preparation is the most effective method for preventing SSIs. |
| format | Article |
| id | doaj-art-78f6034fa53e4388a099abe5f461a241 |
| institution | Kabale University |
| issn | 1895-4588 2299-0054 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Videosurgery and Other Miniinvasive Techniques |
| spelling | doaj-art-78f6034fa53e4388a099abe5f461a2412025-01-29T16:43:17ZengTermedia Publishing HouseVideosurgery and Other Miniinvasive Techniques1895-45882299-00542024-07-0119330832410.20452/wiitm.2024.17885Efficacy of different preoperative antiseptics in preventing a risk of surgical site infections: a systematic review and meta‑analysis of randomized controlled trialsLutao Yang0Shunxin Liao1Qing Cao2Sanjay Rastogi3Department of Burn Plastic and Wound Repair, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang No.1 People’s Hospital, Jiujiang, ChinaDepartment of Burn Plastic and Wound Repair, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang No.1 People’s Hospital, Jiujiang, ChinaDepartment of Burn Plastic and Wound Repair, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang No.1 People’s Hospital, Jiujiang, ChinaBoston University Medical Campus, Boston, Massachusetts, United StatesIntroduction: Surgical site infection (SSI) is a predominant postoperative complication that markedly increases health care expenses. Published systematic reviews, meta-analyses and international guidelines vary in their recommendations for the most effective preoperative skin antiseptic solutions and their concentrations. Aim: The aim of this study was to assess the efficacy of different preoperative antiseptics for preventing the risk of SSIs. Materials and methods: A complete search was conducted using PubMed, EMBASE, Scopus, and Cochrane Library databases to collect peer-reviewed articles. Results: This meta-analysis included 10 587 surgical patients from 18 randomized clinical trials to determine the effectiveness of chlorhexidine in alcohol (CHA; 0.5%, 2%–2.5%, and 4%) with aqueous or alcoholic iodine in preventing postoperative SSIs. This meta-analysis found that 2%–2.5% CHA is the most effective preoperative antiseptic for preventing SSIs, with significant reduction in their incidence and significant antimicrobial activity. Conclusions: The findings of this meta-analysis indicate that for patients undergoing any type of surgery, the use of 2%–2.5% CHA for skin preparation is the most effective method for preventing SSIs.https://www.mp.pl/videosurgery/issue/article/17885/surgical site infectionspreoperative skin antisepticspostoperative wound infectionchlorhexidine alcoholvarious surgeries |
| spellingShingle | Lutao Yang Shunxin Liao Qing Cao Sanjay Rastogi Efficacy of different preoperative antiseptics in preventing a risk of surgical site infections: a systematic review and meta‑analysis of randomized controlled trials Videosurgery and Other Miniinvasive Techniques surgical site infections preoperative skin antiseptics postoperative wound infection chlorhexidine alcohol various surgeries |
| title | Efficacy of different preoperative antiseptics in preventing a risk of surgical site infections: a systematic review and meta‑analysis of randomized controlled trials |
| title_full | Efficacy of different preoperative antiseptics in preventing a risk of surgical site infections: a systematic review and meta‑analysis of randomized controlled trials |
| title_fullStr | Efficacy of different preoperative antiseptics in preventing a risk of surgical site infections: a systematic review and meta‑analysis of randomized controlled trials |
| title_full_unstemmed | Efficacy of different preoperative antiseptics in preventing a risk of surgical site infections: a systematic review and meta‑analysis of randomized controlled trials |
| title_short | Efficacy of different preoperative antiseptics in preventing a risk of surgical site infections: a systematic review and meta‑analysis of randomized controlled trials |
| title_sort | efficacy of different preoperative antiseptics in preventing a risk of surgical site infections a systematic review and meta analysis of randomized controlled trials |
| topic | surgical site infections preoperative skin antiseptics postoperative wound infection chlorhexidine alcohol various surgeries |
| url | https://www.mp.pl/videosurgery/issue/article/17885/ |
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