Efficacy of different preoperative antiseptics in preventing a risk of surgical site infections: a systematic review and meta‑analysis of randomized controlled trials
Introduction: Surgical site infection (SSI) is a predominant postoperative complication that markedly increases health care expenses. Published systematic reviews, meta-analyses and international guidelines vary in their recommendations for the most effective preoperative skin antiseptic solutions a...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2024-07-01
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| Series: | Videosurgery and Other Miniinvasive Techniques |
| Subjects: | |
| Online Access: | https://www.mp.pl/videosurgery/issue/article/17885/ |
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| Summary: | Introduction: Surgical site infection (SSI) is a predominant postoperative complication that markedly increases health care expenses. Published systematic reviews, meta-analyses and international guidelines vary in their recommendations for the most effective preoperative skin antiseptic solutions and their concentrations.
Aim: The aim of this study was to assess the efficacy of different preoperative antiseptics for preventing the risk of SSIs.
Materials and methods: A complete search was conducted using PubMed, EMBASE, Scopus, and Cochrane Library databases to collect peer-reviewed articles.
Results: This meta-analysis included 10 587 surgical patients from 18 randomized clinical trials to determine the effectiveness of chlorhexidine in alcohol (CHA; 0.5%, 2%–2.5%, and 4%) with aqueous or alcoholic iodine in preventing postoperative SSIs. This meta-analysis found that 2%–2.5% CHA is the most effective preoperative antiseptic for preventing SSIs, with significant reduction in their incidence and significant antimicrobial activity.
Conclusions: The findings of this meta-analysis indicate that for patients undergoing any type of surgery, the use of 2%–2.5% CHA for skin preparation is the most effective method for preventing SSIs. |
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| ISSN: | 1895-4588 2299-0054 |