The impact of chronic intermittent hypoxia on enzymatic activity in memory-associated brain regions of male and female rats

Abstract Background Obstructive sleep apnea (OSA) is an intermittent hypoxia disorder associated with cognitive dysfunction, including learning and memory impairments. There is evidence that alterations in protease activity and neuronal activation are associated with cognitive dysfunction, are depen...

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Main Authors: Steve Mabry, Jessica L. Bradshaw, Jennifer J. Gardner, E. Nicole Wilson, Janak Sunuwar, Hannah Yeung, Sharad Shrestha, J. Thomas Cunningham, Rebecca L. Cunningham
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Biology of Sex Differences
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Online Access:https://doi.org/10.1186/s13293-025-00688-6
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