Hyperexcitability of Cortical Oscillations in Patients with Somatoform Pain Disorder: A Resting-State EEG Study
Patients with somatoform pain disorder (SPD) suffer from somatic pain that cannot be fully explained by specific somatic pathology. While the pain experience requires the integration of sensory and contextual processes, the cortical oscillations have been suggested to play a crucial role in pain pro...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2019/2687150 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832563642708525056 |
|---|---|
| author | Qian Ye Dong Yan Manlin Yao Wutao Lou Weiwei Peng |
| author_facet | Qian Ye Dong Yan Manlin Yao Wutao Lou Weiwei Peng |
| author_sort | Qian Ye |
| collection | DOAJ |
| description | Patients with somatoform pain disorder (SPD) suffer from somatic pain that cannot be fully explained by specific somatic pathology. While the pain experience requires the integration of sensory and contextual processes, the cortical oscillations have been suggested to play a crucial role in pain processing and integration. The present study is aimed at identifying the abnormalities of spontaneous cortical oscillations among patients with SPD, thus for a better understanding of the ongoing brain states in these patients. Spontaneous electroencephalography data during a resting state with eyes open were recorded from SPD patients and healthy controls, and their cortical oscillations as well as functional connectivity were compared using both electrode-level and source-level analysis. Compared with healthy controls, SPD patients exhibited greater resting-state alpha oscillations (8.5-12.5 Hz) at the parietal region, as reflected by both electrode-level spectral power density and exact low-resolution brain electromagnetic tomography (eLORETA) cortical current density. A significant correlation between parietal alpha oscillation and somatization severity was observed in SPD patients, after accounting for the influence of anxiety and depression. Functional connectivity analysis further revealed a greater frontoparietal connectivity of the resting-state alpha oscillations in SPD patients, which was indexed by the coherence between pairs of electrodes and the linear connectivity between pairs of eLORETA cortical sources. The enhanced resting-state alpha oscillation in SPD patients could be relevant with attenuated sensory information gating and excessive integration of pain-related information, while the enhanced frontoparietal connectivity could be reflecting their sustained attention to bodily sensations and hypervigilance to somatic sensations. |
| format | Article |
| id | doaj-art-78e56c3fd43e4e37850c5e21e7176110 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-78e56c3fd43e4e37850c5e21e71761102025-02-03T01:13:03ZengWileyNeural Plasticity2090-59041687-54432019-01-01201910.1155/2019/26871502687150Hyperexcitability of Cortical Oscillations in Patients with Somatoform Pain Disorder: A Resting-State EEG StudyQian Ye0Dong Yan1Manlin Yao2Wutao Lou3Weiwei Peng4School of Psychology, Shenzhen University, Shenzhen, ChinaDepartment of Pain Medicine and Shenzhen Municipal Key Laboratory for Pain Medicine, Shenzhen Nanshan People’s Hospital of Shenzhen University Health Science Center, Shenzhen, ChinaSchool of Psychology, Shenzhen University, Shenzhen, ChinaDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong KongSchool of Psychology, Shenzhen University, Shenzhen, ChinaPatients with somatoform pain disorder (SPD) suffer from somatic pain that cannot be fully explained by specific somatic pathology. While the pain experience requires the integration of sensory and contextual processes, the cortical oscillations have been suggested to play a crucial role in pain processing and integration. The present study is aimed at identifying the abnormalities of spontaneous cortical oscillations among patients with SPD, thus for a better understanding of the ongoing brain states in these patients. Spontaneous electroencephalography data during a resting state with eyes open were recorded from SPD patients and healthy controls, and their cortical oscillations as well as functional connectivity were compared using both electrode-level and source-level analysis. Compared with healthy controls, SPD patients exhibited greater resting-state alpha oscillations (8.5-12.5 Hz) at the parietal region, as reflected by both electrode-level spectral power density and exact low-resolution brain electromagnetic tomography (eLORETA) cortical current density. A significant correlation between parietal alpha oscillation and somatization severity was observed in SPD patients, after accounting for the influence of anxiety and depression. Functional connectivity analysis further revealed a greater frontoparietal connectivity of the resting-state alpha oscillations in SPD patients, which was indexed by the coherence between pairs of electrodes and the linear connectivity between pairs of eLORETA cortical sources. The enhanced resting-state alpha oscillation in SPD patients could be relevant with attenuated sensory information gating and excessive integration of pain-related information, while the enhanced frontoparietal connectivity could be reflecting their sustained attention to bodily sensations and hypervigilance to somatic sensations.http://dx.doi.org/10.1155/2019/2687150 |
| spellingShingle | Qian Ye Dong Yan Manlin Yao Wutao Lou Weiwei Peng Hyperexcitability of Cortical Oscillations in Patients with Somatoform Pain Disorder: A Resting-State EEG Study Neural Plasticity |
| title | Hyperexcitability of Cortical Oscillations in Patients with Somatoform Pain Disorder: A Resting-State EEG Study |
| title_full | Hyperexcitability of Cortical Oscillations in Patients with Somatoform Pain Disorder: A Resting-State EEG Study |
| title_fullStr | Hyperexcitability of Cortical Oscillations in Patients with Somatoform Pain Disorder: A Resting-State EEG Study |
| title_full_unstemmed | Hyperexcitability of Cortical Oscillations in Patients with Somatoform Pain Disorder: A Resting-State EEG Study |
| title_short | Hyperexcitability of Cortical Oscillations in Patients with Somatoform Pain Disorder: A Resting-State EEG Study |
| title_sort | hyperexcitability of cortical oscillations in patients with somatoform pain disorder a resting state eeg study |
| url | http://dx.doi.org/10.1155/2019/2687150 |
| work_keys_str_mv | AT qianye hyperexcitabilityofcorticaloscillationsinpatientswithsomatoformpaindisorderarestingstateeegstudy AT dongyan hyperexcitabilityofcorticaloscillationsinpatientswithsomatoformpaindisorderarestingstateeegstudy AT manlinyao hyperexcitabilityofcorticaloscillationsinpatientswithsomatoformpaindisorderarestingstateeegstudy AT wutaolou hyperexcitabilityofcorticaloscillationsinpatientswithsomatoformpaindisorderarestingstateeegstudy AT weiweipeng hyperexcitabilityofcorticaloscillationsinpatientswithsomatoformpaindisorderarestingstateeegstudy |