Predictive role of the prognostic nutritional index for long-term prognosis among patients undergoing pancreatoduodenectomy: a meta-analysis
Abstract Purpose To identify the predictive role of the preoperative prognostic nutritional index (PNI) for long-term survival in patients undergoing pancreatoduodenectomy. Methods The PubMed, EMBASE, Web of Science, Cochrane Library and CNKI databases were searched up to October 28, 2024. The prima...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12893-024-02757-w |
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| author | Ying Liu Keyu Li |
| author_facet | Ying Liu Keyu Li |
| author_sort | Ying Liu |
| collection | DOAJ |
| description | Abstract Purpose To identify the predictive role of the preoperative prognostic nutritional index (PNI) for long-term survival in patients undergoing pancreatoduodenectomy. Methods The PubMed, EMBASE, Web of Science, Cochrane Library and CNKI databases were searched up to October 28, 2024. The primary outcomes included overall survival (OS) and disease-free survival (DFS). Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated, and subgroup analyses by country, type of cancer and source of HR were performed. Results Fifteen studies with 2106 patients were included. The pooled results demonstrated that a lower preoperative PNI was related to poorer OS (HR = 1.60, 95% CI: 1.38–1.86, P < 0.001) and DFS (HR = 1.44, 95% CI: 1.00–2.07, P = 0.051). Subgroup analysis stratified by country (China vs. non-China), type of cancer (pancreatic cancer vs. nonpancreatic cancer vs. mixed) and source of HR (univariate vs. multivariate analysis) revealed similar results. Conclusion On the basis of the available evidence, the preoperative PNI might serve as a novel prognostic indicator in patients undergoing pancreatoduodenectomy, with a lower PNI predicting worse survival. However, more high-quality studies are needed to further verify the above findings. |
| format | Article |
| id | doaj-art-78e1f16785af4b4884ccb01725f054e1 |
| institution | Kabale University |
| issn | 1471-2482 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Surgery |
| spelling | doaj-art-78e1f16785af4b4884ccb01725f054e12025-02-02T12:06:22ZengBMCBMC Surgery1471-24822025-01-012511810.1186/s12893-024-02757-wPredictive role of the prognostic nutritional index for long-term prognosis among patients undergoing pancreatoduodenectomy: a meta-analysisYing Liu0Keyu Li1Division of Pancreatic Surgery, Department of General Surgery, West China Hospital, Sichuan UniversityDivision of Pancreatic Surgery, Department of General Surgery, West China Hospital, Sichuan UniversityAbstract Purpose To identify the predictive role of the preoperative prognostic nutritional index (PNI) for long-term survival in patients undergoing pancreatoduodenectomy. Methods The PubMed, EMBASE, Web of Science, Cochrane Library and CNKI databases were searched up to October 28, 2024. The primary outcomes included overall survival (OS) and disease-free survival (DFS). Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated, and subgroup analyses by country, type of cancer and source of HR were performed. Results Fifteen studies with 2106 patients were included. The pooled results demonstrated that a lower preoperative PNI was related to poorer OS (HR = 1.60, 95% CI: 1.38–1.86, P < 0.001) and DFS (HR = 1.44, 95% CI: 1.00–2.07, P = 0.051). Subgroup analysis stratified by country (China vs. non-China), type of cancer (pancreatic cancer vs. nonpancreatic cancer vs. mixed) and source of HR (univariate vs. multivariate analysis) revealed similar results. Conclusion On the basis of the available evidence, the preoperative PNI might serve as a novel prognostic indicator in patients undergoing pancreatoduodenectomy, with a lower PNI predicting worse survival. However, more high-quality studies are needed to further verify the above findings.https://doi.org/10.1186/s12893-024-02757-wPrognostic nutritional indexPancreatoduodenectomyOverall survivalDisease-free survivalMeta-analysis |
| spellingShingle | Ying Liu Keyu Li Predictive role of the prognostic nutritional index for long-term prognosis among patients undergoing pancreatoduodenectomy: a meta-analysis BMC Surgery Prognostic nutritional index Pancreatoduodenectomy Overall survival Disease-free survival Meta-analysis |
| title | Predictive role of the prognostic nutritional index for long-term prognosis among patients undergoing pancreatoduodenectomy: a meta-analysis |
| title_full | Predictive role of the prognostic nutritional index for long-term prognosis among patients undergoing pancreatoduodenectomy: a meta-analysis |
| title_fullStr | Predictive role of the prognostic nutritional index for long-term prognosis among patients undergoing pancreatoduodenectomy: a meta-analysis |
| title_full_unstemmed | Predictive role of the prognostic nutritional index for long-term prognosis among patients undergoing pancreatoduodenectomy: a meta-analysis |
| title_short | Predictive role of the prognostic nutritional index for long-term prognosis among patients undergoing pancreatoduodenectomy: a meta-analysis |
| title_sort | predictive role of the prognostic nutritional index for long term prognosis among patients undergoing pancreatoduodenectomy a meta analysis |
| topic | Prognostic nutritional index Pancreatoduodenectomy Overall survival Disease-free survival Meta-analysis |
| url | https://doi.org/10.1186/s12893-024-02757-w |
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