Fatigue in living kidney donors compared to a German general population sample: an exploratory study
BackgroundClinical studies have not conclusively clarified whether fatigue scores in living kidney donors after donation are fundamentally different from general population samples. Moreover, the association between sociodemographic and donor specific factors and fatigue in donors is not well unders...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1510738/full |
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| author | Dilek Akkus Adrian Westenberger Gunilla Einecke Gunilla Einecke Wilfried Gwinner Uwe Tegtbur Mariel Nöhre Martina de Zwaan |
| author_facet | Dilek Akkus Adrian Westenberger Gunilla Einecke Gunilla Einecke Wilfried Gwinner Uwe Tegtbur Mariel Nöhre Martina de Zwaan |
| author_sort | Dilek Akkus |
| collection | DOAJ |
| description | BackgroundClinical studies have not conclusively clarified whether fatigue scores in living kidney donors after donation are fundamentally different from general population samples. Moreover, the association between sociodemographic and donor specific factors and fatigue in donors is not well understood.Patients and methodsFatigue scores of 358 living kidney donors on average 7.67 years post-donation were compared with 1896 subjects from the German general population in five strata of age and sex. Fatigue was measured with the Multidimensional Fatigue Inventory (MFI-20). Relationships between the five MFI-20 subscales and the sociodemographic variables sex, age, education, and in the donor sample also years since donation were calculated. Additionally, the association between donor specific variables and fatigue levels were analyzed.ResultsOverall, donors had lower fatigue scores than the population sample. Particularly the age group 65-74 and above reported significantly lower fatigue scores. A significant exception was found in women aged 45-54 years, where donors showed significant higher general fatigue scores than the corresponding subgroup of the general population sample. Multiple regression analyses in the general population sample revealed associations between female sex and higher age with higher values in most MFI-20 subscales, whereas subjects with higher education showed mostly lower fatigue scores. In the donor group, these associations were of little importance. Also, years since donation, partnership, and recipient group were not strongly related to fatigue. However, higher fatigue in donors was associated with more donation regret, a more negative relationship with the recipient, a more negatively perceived recipient health, less perceived family support, and more financial burden.ConclusionFatigue is less prevalent particularly in older donors and predictors of fatigue presented in the general population sample seem to have little importance in the donors. However, middle-aged female donors might be more prone to develop fatigue. This group may require more intense exploration before and after donation to detect and treat the underlying factors timely. |
| format | Article |
| id | doaj-art-78cf659f8127496daf13da67f9ff687d |
| institution | Kabale University |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-78cf659f8127496daf13da67f9ff687d2025-01-30T06:22:39ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-01-011510.3389/fpsyt.2024.15107381510738Fatigue in living kidney donors compared to a German general population sample: an exploratory studyDilek Akkus0Adrian Westenberger1Gunilla Einecke2Gunilla Einecke3Wilfried Gwinner4Uwe Tegtbur5Mariel Nöhre6Martina de Zwaan7Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, GermanyDepartment of Nephrology and Rheumatology, University Medical Center Göttingen, Göttingen, GermanyDepartment of Nephrology and Hypertension, Hannover Medical School, Hannover, GermanyDepartment of Nephrology and Hypertension, Hannover Medical School, Hannover, GermanyDepartment of Rehabilitation and Sports Medicine, Hannover Medical School, Hannover, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, GermanyBackgroundClinical studies have not conclusively clarified whether fatigue scores in living kidney donors after donation are fundamentally different from general population samples. Moreover, the association between sociodemographic and donor specific factors and fatigue in donors is not well understood.Patients and methodsFatigue scores of 358 living kidney donors on average 7.67 years post-donation were compared with 1896 subjects from the German general population in five strata of age and sex. Fatigue was measured with the Multidimensional Fatigue Inventory (MFI-20). Relationships between the five MFI-20 subscales and the sociodemographic variables sex, age, education, and in the donor sample also years since donation were calculated. Additionally, the association between donor specific variables and fatigue levels were analyzed.ResultsOverall, donors had lower fatigue scores than the population sample. Particularly the age group 65-74 and above reported significantly lower fatigue scores. A significant exception was found in women aged 45-54 years, where donors showed significant higher general fatigue scores than the corresponding subgroup of the general population sample. Multiple regression analyses in the general population sample revealed associations between female sex and higher age with higher values in most MFI-20 subscales, whereas subjects with higher education showed mostly lower fatigue scores. In the donor group, these associations were of little importance. Also, years since donation, partnership, and recipient group were not strongly related to fatigue. However, higher fatigue in donors was associated with more donation regret, a more negative relationship with the recipient, a more negatively perceived recipient health, less perceived family support, and more financial burden.ConclusionFatigue is less prevalent particularly in older donors and predictors of fatigue presented in the general population sample seem to have little importance in the donors. However, middle-aged female donors might be more prone to develop fatigue. This group may require more intense exploration before and after donation to detect and treat the underlying factors timely.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1510738/fullliving kidney donationfatigueMFI-20sexageeducation |
| spellingShingle | Dilek Akkus Adrian Westenberger Gunilla Einecke Gunilla Einecke Wilfried Gwinner Uwe Tegtbur Mariel Nöhre Martina de Zwaan Fatigue in living kidney donors compared to a German general population sample: an exploratory study Frontiers in Psychiatry living kidney donation fatigue MFI-20 sex age education |
| title | Fatigue in living kidney donors compared to a German general population sample: an exploratory study |
| title_full | Fatigue in living kidney donors compared to a German general population sample: an exploratory study |
| title_fullStr | Fatigue in living kidney donors compared to a German general population sample: an exploratory study |
| title_full_unstemmed | Fatigue in living kidney donors compared to a German general population sample: an exploratory study |
| title_short | Fatigue in living kidney donors compared to a German general population sample: an exploratory study |
| title_sort | fatigue in living kidney donors compared to a german general population sample an exploratory study |
| topic | living kidney donation fatigue MFI-20 sex age education |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1510738/full |
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