Aloe Vera Extract-Mediated CuO NPs as Catalysts for the Synthesis of 4-Hydroxy-3-Methoxybenzaldehyde-Connected Piperidine Derivatives and Their Antibacterial Activity
We have designed an easy, affordable, and eco-friendly technique for Schiff base preparation of vanillin-coupled piperidine analogues using CuO NPs as a catalyst. Using a green chemistry strategy using copper oxide nanoparticles (CuO NPs) as a catalyst, a unique one-pot synthesis of Schiff base vani...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2023/2113151 |
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| author | Ponnusamy Packialakshmi Perumal Gobinath Anis Ahamed Hissah Abdulrahman Alodaini Ashraf Atef Hatamleh Mohamed Taha Yassin Akbar Idhayadhulla Radhakrishnan Surendrakumar |
| author_facet | Ponnusamy Packialakshmi Perumal Gobinath Anis Ahamed Hissah Abdulrahman Alodaini Ashraf Atef Hatamleh Mohamed Taha Yassin Akbar Idhayadhulla Radhakrishnan Surendrakumar |
| author_sort | Ponnusamy Packialakshmi |
| collection | DOAJ |
| description | We have designed an easy, affordable, and eco-friendly technique for Schiff base preparation of vanillin-coupled piperidine analogues using CuO NPs as a catalyst. Using a green chemistry strategy using copper oxide nanoparticles (CuO NPs) as a catalyst, a unique one-pot synthesis of Schiff base vanillin-linked piperidine derivatives (2, 2a-2j) may be generated, with a potential yield in a short reaction time. The CuO NPs were synthesized with the aloe vera extract. The newly synthesized piperidin-4-ylidene analogues were investigated using FT-IR, NMR (1H, 13C), mass spectra, and elemental analysis. The morphology of piperidine derivatives was studied using XRD and TEM. The compound 2a-2j was evaluated for antibacterial activity against gram +ve and gram −ve bacteria. Compound 2d is exceptionally active against (5.0 μg/mL, E. coli), and 2c is very effective against (4.0 μg/mL, L. plantarum) when compared to reference drug and other Schiff base of vanillin-associated piperidine derivatives. Finally, we concluded the compounds 2c and 2d have strong antibacterial activity and can be used as antibacterial drugs in the future. |
| format | Article |
| id | doaj-art-78bcb5b6f3704c2999e3353ca90e74bd |
| institution | Kabale University |
| issn | 2090-9071 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-78bcb5b6f3704c2999e3353ca90e74bd2025-02-03T06:42:45ZengWileyJournal of Chemistry2090-90712023-01-01202310.1155/2023/2113151Aloe Vera Extract-Mediated CuO NPs as Catalysts for the Synthesis of 4-Hydroxy-3-Methoxybenzaldehyde-Connected Piperidine Derivatives and Their Antibacterial ActivityPonnusamy Packialakshmi0Perumal Gobinath1Anis Ahamed2Hissah Abdulrahman Alodaini3Ashraf Atef Hatamleh4Mohamed Taha Yassin5Akbar Idhayadhulla6Radhakrishnan Surendrakumar7Department of ChemistryDepartment of ChemistryDepartment of Botany & MicrobiologyDepartment of Botany & MicrobiologyDepartment of Botany & MicrobiologyDepartment of Botany & MicrobiologyDepartment of ChemistryDepartment of ChemistryWe have designed an easy, affordable, and eco-friendly technique for Schiff base preparation of vanillin-coupled piperidine analogues using CuO NPs as a catalyst. Using a green chemistry strategy using copper oxide nanoparticles (CuO NPs) as a catalyst, a unique one-pot synthesis of Schiff base vanillin-linked piperidine derivatives (2, 2a-2j) may be generated, with a potential yield in a short reaction time. The CuO NPs were synthesized with the aloe vera extract. The newly synthesized piperidin-4-ylidene analogues were investigated using FT-IR, NMR (1H, 13C), mass spectra, and elemental analysis. The morphology of piperidine derivatives was studied using XRD and TEM. The compound 2a-2j was evaluated for antibacterial activity against gram +ve and gram −ve bacteria. Compound 2d is exceptionally active against (5.0 μg/mL, E. coli), and 2c is very effective against (4.0 μg/mL, L. plantarum) when compared to reference drug and other Schiff base of vanillin-associated piperidine derivatives. Finally, we concluded the compounds 2c and 2d have strong antibacterial activity and can be used as antibacterial drugs in the future.http://dx.doi.org/10.1155/2023/2113151 |
| spellingShingle | Ponnusamy Packialakshmi Perumal Gobinath Anis Ahamed Hissah Abdulrahman Alodaini Ashraf Atef Hatamleh Mohamed Taha Yassin Akbar Idhayadhulla Radhakrishnan Surendrakumar Aloe Vera Extract-Mediated CuO NPs as Catalysts for the Synthesis of 4-Hydroxy-3-Methoxybenzaldehyde-Connected Piperidine Derivatives and Their Antibacterial Activity Journal of Chemistry |
| title | Aloe Vera Extract-Mediated CuO NPs as Catalysts for the Synthesis of 4-Hydroxy-3-Methoxybenzaldehyde-Connected Piperidine Derivatives and Their Antibacterial Activity |
| title_full | Aloe Vera Extract-Mediated CuO NPs as Catalysts for the Synthesis of 4-Hydroxy-3-Methoxybenzaldehyde-Connected Piperidine Derivatives and Their Antibacterial Activity |
| title_fullStr | Aloe Vera Extract-Mediated CuO NPs as Catalysts for the Synthesis of 4-Hydroxy-3-Methoxybenzaldehyde-Connected Piperidine Derivatives and Their Antibacterial Activity |
| title_full_unstemmed | Aloe Vera Extract-Mediated CuO NPs as Catalysts for the Synthesis of 4-Hydroxy-3-Methoxybenzaldehyde-Connected Piperidine Derivatives and Their Antibacterial Activity |
| title_short | Aloe Vera Extract-Mediated CuO NPs as Catalysts for the Synthesis of 4-Hydroxy-3-Methoxybenzaldehyde-Connected Piperidine Derivatives and Their Antibacterial Activity |
| title_sort | aloe vera extract mediated cuo nps as catalysts for the synthesis of 4 hydroxy 3 methoxybenzaldehyde connected piperidine derivatives and their antibacterial activity |
| url | http://dx.doi.org/10.1155/2023/2113151 |
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