Lung function and onset of cardiometabolic diseases in the longitudinal Burden of Obstructive Lung Disease study

Introduction Previous population-based studies, mainly from high-income countries, have shown that a higher forced vital capacity (FVC) is associated with a lower risk of developing cardiometabolic diseases. The aim of this study was to assess the longitudinal association between spirometry measures...

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Main Authors:	Andre F S Amaral, Andrzej Pająk, Thorarinn Gislason, Syed Masud Ahmed, Rain Jogi, Abdul Rashid, Christine Jenkins, Fiona McLean, James Potts, Tobias Welte, Dali Wang, Eric Bateman, Wen Wang, Zafar Fatmi, Kevin Mortimer, Christer Janson, Nanshan Zhong, João Cardoso, Parvaiz A Koul, Rune Nielsen, Nazrul Islam, Graham Devereux, Andrei Malinovschi, Sanjay Juvekar, Talant Sooronbaev, Berik Emilov, Bertrand Mbatchou, Ayola Akim Adegnika, Padukudru Anand Mahesh, Kate Hardaker, EFM Wouters, Imed Harrabi, Amund Gulsvik, Sundeep Salvi, Muhammad Irfan, Bill Brashier, Inga Sif Ólafsdóttir, Zouhair Tabka, Peter G J Burney, Jaymini Patel, Filip Mejza, David M Mannino, Meriam Denguezli, Michael Studnicka, Althea Aquart-Stewart, Parvaiz Koul, Herve Lawin, Asaad Ahmed Nafees, Olayemi Awopeju, Gregory E Erhabor, Louisa Gnatiuc, Ali Kocabas, Cristina Barbara, Hasan Hafizi, Anila Aliko, Donika Bardhi, Holta Tafa, Natasha Thanasi, Arian Mezini, Alma Teferici, Dafina Todri, Jolanda Nikolla, Rezarta Kazasi, Hamid Hacene Cherkaski, Amira Bengrait, Tabarek Haddad, Ibtissem Zgaoula, Maamar Ghit, Abdelhamid Roubhia, Soumaya Boudra, Feryal Atoui, Randa Yakoubi, Rachid Benali, Abdelghani Bencheikh, Nadia Ait-Khaled, Guy Marks, Tessa Bird, Paola Espinel, Brett Toelle, Torkil Dawes, Bernd Lamprecht, Lea Schirhofer, Akramul Islam, Shayla Islam, Qazi Shafayetul Islam, Mesbah Ul-Haque, Tridib Roy Chowdhury, Sukantha Kumar Chatterjee, Dulal Mia, Shyamal Chandra Das, Mizanur Rahman, Shahaz Uddin, Nurul Islam, Luiza Khatun, Monira Parvin, Abdul Awal Khan, Maidul Islam, Arsene Kpangon, Karl Kpossou, Gildas Agodokpessi, Paul Ayelo, Benjamin Fayomi, Atongno Humphrey Ashu, Wan C Tan, Shengming Liu, Jiachun Lu, Pixin Ran, Yumin Zhou, Hendrik Laja, Katrin Ulst, Vappu Zobel, Toomas-Julius Lill, Isabelle Bodemann, Henning Geldmacher, Bryndis Benedikdtsdottir, Kristin Jörundsdottir, Lovisa Gudmundsdottir, Sigrun Gudmundsdottir, Mahesh Rao, Sajjad Malik, Nissar A Hakim, Umar Hafiz Khan, Rohini Chowgule, Vasant Shetye, Jonelle Raphael, Rosel Almeda, Mahesh Tawde, Rafiq Tadvi, Sunil Katkar, Milind Kadam, Rupesh Dhanawade, Umesh Ghurup, Siddhi Hirve, Somnath Sambhudas, Bharat Chaidhary, Meera Tambe, Savita Pingale, Arati Umap, Archana Umap, Nitin Shelar, Sampada Devchakke, Sharda Chaudhary, Suvarna Bondre, Savita Walke, Ashleshsa Gawhane, Anil Sapkal, Rupali Argade, Vijay Gaikwad, Jyoti Londhe, Sapna Madas, Akosua Francia Aikman, Meerim Akmatalieva, Saadat Usenbaeva, Jypara Kydyrova, Eliza Bostonova, Ulan Sheraliev, Nuridin Marajapov, Nurgul Toktogulova, Toktogul Azilova, Gulnara Beishekeeva, Nasyikat Dononbaeva, Aijamal Tabyshova, Wezzie Nyapigoti, Ernest Mwangoka, Mayamiko Kambwili, Martha Chipeta, Gloria Banda, Suzgo Mkandawire, Justice Banda, Li-Cher Loh, Siti Sholehah, Mohamed C Benjelloun, Chakib Nejjari, Mohamed Elbiaze, Karima El Rhazi, Daniel Obaseki, Gregory Erhabor, Olufemi Adewole, Tina Endresen, Lene Svendsen, Asaad A Nafees, Aysha Zahidie, Natasha Shaukat, Meesha Iqbal, Luisito F Idolor, Norberto A Francisco, Camilo C Roa, Fernando G Ayuyao, Cecil Z Tady, Daniel T Tan, Sylvia Banal-Yang, Vincent M Balanag, Renato B Dantes, Lourdes Amarillo, Lakan U Berratio, Lenora C Fernandez, Gerard S Garcia, Teresita S de Guia, Thessa Reyes, Leander P Simpao, Jakub Frey, Rafal Harat, Pawel Nastalek, Wojciech Skucha, Andrzej Szczeklik, Magda Twardowska, Fátima Rodrigues, Hermínia Dias, João Almeida, Maria João Matos, Paula Simão, Moutinho Santos, Reis Ferreira, H Alorainy, E El-Hamad, A Hashi, R Dela, R Fanuncio, E Doloriel, I Marciano, Anamika Jithoo, Desiree Adams, Edward Barnes, Jasper Freeman, Anton Hayes, Sipho Hlengwa, Christine Johannisen, Mariana Koopman, Innocentia Louw, Ina Ludick, Alta Olckers, Johanna Ryck, Janita Storbeck, Kirthi Gunasekera, Rajitha Wickremasinghe, Asma Elsony, Hana A Elsadig, Nada Bakery Osman, Bandar Salah Noory, Monjda Awad Mohamed, Suhaiba Khalifa, Mahmoud Elhadi, Mohand Hassan, Dalia Abdelmonam, Katarina Nisser, Gunilla Hägg, Terence Seemungal, Fallon Lutchmansingh, Liane Conyette, Myriam Denguezli, Hager Daldoul, Zaki Boukheroufa, Firas Chouikha, Wahbi Belhaj Khalifa, Attila Hancioglu, Ismail Hanta, Sedat Kuleci, Ahmet Sinan Turkyilmaz, Sema Umut, Turgay Unalan, Peter GJ Burney, Hadia Azar, Caron Amor, Michael Tumilty, Risha Dudhaiya, A Sonia Buist, Mary Ann McBurnie, William M Vollmer, Suzanne Gillespie, Sean Sullivan, Todd A Lee, Kevin B Weiss, Robert L Jensen, Robert Crapo, Paul Enright, John Cain, Rebecca Copeland, Dana Hazen, Jennifer Methvin, Rana Ahmed, Ewa Niżankowska-mogilnicka, Sullian S Naval, Jin-Ping Zheng, Gunnar Gudmundsson, Ben Knox-Brown, Dhiraj Agarwal, M Al Hajjaj, L Safia, Namarig Mohamed Elhassan, Marwa Mohamed Mohamaden, Sanjay K Juvekar, Stefanni Nonna M Paraguas, Anders Ørskov Rotevatn, Alexandra SchwedaLinow, Talant M. Sooronbaev, Bermet M. Estebesova, GJ Wesseling, MariaTeresita N Reyes, Flordeliza Sanchez, MAl Ghobain, Hasab Alrasoul Akasha Ahmed Osman, Abdel Mu’is El Zain, Ulrike SpetzNystrom, GunMarie Lund
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2025-01-01
Series:	BMJ Open Respiratory Research
Online Access:	https://bmjopenrespres.bmj.com/content/12/1/e002442.full
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author	Andre F S Amaral Andrzej Pająk Thorarinn Gislason Syed Masud Ahmed Rain Jogi Abdul Rashid Christine Jenkins Fiona McLean James Potts Tobias Welte Dali Wang Eric Bateman Wen Wang Zafar Fatmi Kevin Mortimer Christer Janson Nanshan Zhong João Cardoso Parvaiz A Koul Rune Nielsen Nazrul Islam Graham Devereux Andrei Malinovschi Sanjay Juvekar Talant Sooronbaev Berik Emilov Bertrand Mbatchou Ayola Akim Adegnika Padukudru Anand Mahesh Kate Hardaker EFM Wouters Imed Harrabi Amund Gulsvik Sundeep Salvi Muhammad Irfan Bill Brashier Inga Sif Ólafsdóttir Zouhair Tabka Peter G J Burney Jaymini Patel Filip Mejza David M Mannino Meriam Denguezli Michael Studnicka Althea Aquart-Stewart Parvaiz Koul Herve Lawin Asaad Ahmed Nafees Olayemi Awopeju Gregory E Erhabor Louisa Gnatiuc Ali Kocabas Cristina Barbara Hasan Hafizi Anila Aliko Donika Bardhi Holta Tafa Natasha Thanasi Arian Mezini Alma Teferici Dafina Todri Jolanda Nikolla Rezarta Kazasi Hamid Hacene Cherkaski Amira Bengrait Tabarek Haddad Ibtissem Zgaoula Maamar Ghit Abdelhamid Roubhia Soumaya Boudra Feryal Atoui Randa Yakoubi Rachid Benali Abdelghani Bencheikh Nadia Ait-Khaled Guy Marks Tessa Bird Paola Espinel Brett Toelle Torkil Dawes Bernd Lamprecht Lea Schirhofer Akramul Islam Shayla Islam Qazi Shafayetul Islam Mesbah Ul-Haque Tridib Roy Chowdhury Sukantha Kumar Chatterjee Dulal Mia Shyamal Chandra Das Mizanur Rahman Shahaz Uddin Nurul Islam Luiza Khatun Monira Parvin Abdul Awal Khan Maidul Islam Arsene Kpangon Karl Kpossou Gildas Agodokpessi Paul Ayelo Benjamin Fayomi Atongno Humphrey Ashu Wan C Tan Shengming Liu Jiachun Lu Pixin Ran Yumin Zhou Hendrik Laja Katrin Ulst Vappu Zobel Toomas-Julius Lill Isabelle Bodemann Henning Geldmacher Bryndis Benedikdtsdottir Kristin Jörundsdottir Lovisa Gudmundsdottir Sigrun Gudmundsdottir Mahesh Rao Sajjad Malik Nissar A Hakim Umar Hafiz Khan Rohini Chowgule Vasant Shetye Jonelle Raphael Rosel Almeda Mahesh Tawde Rafiq Tadvi Sunil Katkar Milind Kadam Rupesh Dhanawade Umesh Ghurup Siddhi Hirve Somnath Sambhudas Bharat Chaidhary Meera Tambe Savita Pingale Arati Umap Archana Umap Nitin Shelar Sampada Devchakke Sharda Chaudhary Suvarna Bondre Savita Walke Ashleshsa Gawhane Anil Sapkal Rupali Argade Vijay Gaikwad Jyoti Londhe Sapna Madas Akosua Francia Aikman Meerim Akmatalieva Saadat Usenbaeva Jypara Kydyrova Eliza Bostonova Ulan Sheraliev Nuridin Marajapov Nurgul Toktogulova Toktogul Azilova Gulnara Beishekeeva Nasyikat Dononbaeva Aijamal Tabyshova Wezzie Nyapigoti Ernest Mwangoka Mayamiko Kambwili Martha Chipeta Gloria Banda Suzgo Mkandawire Justice Banda Li-Cher Loh Siti Sholehah Mohamed C Benjelloun Chakib Nejjari Mohamed Elbiaze Karima El Rhazi Daniel Obaseki Gregory Erhabor Olufemi Adewole Tina Endresen Lene Svendsen Asaad A Nafees Aysha Zahidie Natasha Shaukat Meesha Iqbal Luisito F Idolor Norberto A Francisco Camilo C Roa Fernando G Ayuyao Cecil Z Tady Daniel T Tan Sylvia Banal-Yang Vincent M Balanag Renato B Dantes Lourdes Amarillo Lakan U Berratio Lenora C Fernandez Gerard S Garcia Teresita S de Guia Thessa Reyes Leander P Simpao Jakub Frey Rafal Harat Pawel Nastalek Wojciech Skucha Andrzej Szczeklik Magda Twardowska Fátima Rodrigues Hermínia Dias João Almeida Maria João Matos Paula Simão Moutinho Santos Reis Ferreira H Alorainy E El-Hamad A Hashi R Dela R Fanuncio E Doloriel I Marciano Anamika Jithoo Desiree Adams Edward Barnes Jasper Freeman Anton Hayes Sipho Hlengwa Christine Johannisen Mariana Koopman Innocentia Louw Ina Ludick Alta Olckers Johanna Ryck Janita Storbeck Kirthi Gunasekera Rajitha Wickremasinghe Asma Elsony Hana A Elsadig Nada Bakery Osman Bandar Salah Noory Monjda Awad Mohamed Suhaiba Khalifa Mahmoud Elhadi Mohand Hassan Dalia Abdelmonam Katarina Nisser Gunilla Hägg Terence Seemungal Fallon Lutchmansingh Liane Conyette Myriam Denguezli Hager Daldoul Zaki Boukheroufa Firas Chouikha Wahbi Belhaj Khalifa Attila Hancioglu Ismail Hanta Sedat Kuleci Ahmet Sinan Turkyilmaz Sema Umut Turgay Unalan Peter GJ Burney Hadia Azar Caron Amor Michael Tumilty Risha Dudhaiya A Sonia Buist Mary Ann McBurnie William M Vollmer Suzanne Gillespie Sean Sullivan Todd A Lee Kevin B Weiss Robert L Jensen Robert Crapo Paul Enright John Cain Rebecca Copeland Dana Hazen Jennifer Methvin Rana Ahmed Ewa Niżankowska-mogilnicka Sullian S Naval Jin-Ping Zheng Gunnar Gudmundsson Ben Knox-Brown Dhiraj Agarwal M Al Hajjaj L Safia Namarig Mohamed Elhassan Marwa Mohamed Mohamaden Sanjay K Juvekar Stefanni Nonna M Paraguas Anders Ørskov Rotevatn Alexandra SchwedaLinow Talant M. Sooronbaev Bermet M. Estebesova GJ Wesseling MariaTeresita N Reyes Flordeliza Sanchez MAl Ghobain Hasab Alrasoul Akasha Ahmed Osman Abdel Mu’is El Zain Ulrike SpetzNystrom GunMarie Lund
author_facet	Andre F S Amaral Andrzej Pająk Thorarinn Gislason Syed Masud Ahmed Rain Jogi Abdul Rashid Christine Jenkins Fiona McLean James Potts Tobias Welte Dali Wang Eric Bateman Wen Wang Zafar Fatmi Kevin Mortimer Christer Janson Nanshan Zhong João Cardoso Parvaiz A Koul Rune Nielsen Nazrul Islam Graham Devereux Andrei Malinovschi Sanjay Juvekar Talant Sooronbaev Berik Emilov Bertrand Mbatchou Ayola Akim Adegnika Padukudru Anand Mahesh Kate Hardaker EFM Wouters Imed Harrabi Amund Gulsvik Sundeep Salvi Muhammad Irfan Bill Brashier Inga Sif Ólafsdóttir Zouhair Tabka Peter G J Burney Jaymini Patel Filip Mejza David M Mannino Meriam Denguezli Michael Studnicka Althea Aquart-Stewart Parvaiz Koul Herve Lawin Asaad Ahmed Nafees Olayemi Awopeju Gregory E Erhabor Louisa Gnatiuc Ali Kocabas Cristina Barbara Hasan Hafizi Anila Aliko Donika Bardhi Holta Tafa Natasha Thanasi Arian Mezini Alma Teferici Dafina Todri Jolanda Nikolla Rezarta Kazasi Hamid Hacene Cherkaski Amira Bengrait Tabarek Haddad Ibtissem Zgaoula Maamar Ghit Abdelhamid Roubhia Soumaya Boudra Feryal Atoui Randa Yakoubi Rachid Benali Abdelghani Bencheikh Nadia Ait-Khaled Guy Marks Tessa Bird Paola Espinel Brett Toelle Torkil Dawes Bernd Lamprecht Lea Schirhofer Akramul Islam Shayla Islam Qazi Shafayetul Islam Mesbah Ul-Haque Tridib Roy Chowdhury Sukantha Kumar Chatterjee Dulal Mia Shyamal Chandra Das Mizanur Rahman Shahaz Uddin Nurul Islam Luiza Khatun Monira Parvin Abdul Awal Khan Maidul Islam Arsene Kpangon Karl Kpossou Gildas Agodokpessi Paul Ayelo Benjamin Fayomi Atongno Humphrey Ashu Wan C Tan Shengming Liu Jiachun Lu Pixin Ran Yumin Zhou Hendrik Laja Katrin Ulst Vappu Zobel Toomas-Julius Lill Isabelle Bodemann Henning Geldmacher Bryndis Benedikdtsdottir Kristin Jörundsdottir Lovisa Gudmundsdottir Sigrun Gudmundsdottir Mahesh Rao Sajjad Malik Nissar A Hakim Umar Hafiz Khan Rohini Chowgule Vasant Shetye Jonelle Raphael Rosel Almeda Mahesh Tawde Rafiq Tadvi Sunil Katkar Milind Kadam Rupesh Dhanawade Umesh Ghurup Siddhi Hirve Somnath Sambhudas Bharat Chaidhary Meera Tambe Savita Pingale Arati Umap Archana Umap Nitin Shelar Sampada Devchakke Sharda Chaudhary Suvarna Bondre Savita Walke Ashleshsa Gawhane Anil Sapkal Rupali Argade Vijay Gaikwad Jyoti Londhe Sapna Madas Akosua Francia Aikman Meerim Akmatalieva Saadat Usenbaeva Jypara Kydyrova Eliza Bostonova Ulan Sheraliev Nuridin Marajapov Nurgul Toktogulova Toktogul Azilova Gulnara Beishekeeva Nasyikat Dononbaeva Aijamal Tabyshova Wezzie Nyapigoti Ernest Mwangoka Mayamiko Kambwili Martha Chipeta Gloria Banda Suzgo Mkandawire Justice Banda Li-Cher Loh Siti Sholehah Mohamed C Benjelloun Chakib Nejjari Mohamed Elbiaze Karima El Rhazi Daniel Obaseki Gregory Erhabor Olufemi Adewole Tina Endresen Lene Svendsen Asaad A Nafees Aysha Zahidie Natasha Shaukat Meesha Iqbal Luisito F Idolor Norberto A Francisco Camilo C Roa Fernando G Ayuyao Cecil Z Tady Daniel T Tan Sylvia Banal-Yang Vincent M Balanag Renato B Dantes Lourdes Amarillo Lakan U Berratio Lenora C Fernandez Gerard S Garcia Teresita S de Guia Thessa Reyes Leander P Simpao Jakub Frey Rafal Harat Pawel Nastalek Wojciech Skucha Andrzej Szczeklik Magda Twardowska Fátima Rodrigues Hermínia Dias João Almeida Maria João Matos Paula Simão Moutinho Santos Reis Ferreira H Alorainy E El-Hamad A Hashi R Dela R Fanuncio E Doloriel I Marciano Anamika Jithoo Desiree Adams Edward Barnes Jasper Freeman Anton Hayes Sipho Hlengwa Christine Johannisen Mariana Koopman Innocentia Louw Ina Ludick Alta Olckers Johanna Ryck Janita Storbeck Kirthi Gunasekera Rajitha Wickremasinghe Asma Elsony Hana A Elsadig Nada Bakery Osman Bandar Salah Noory Monjda Awad Mohamed Suhaiba Khalifa Mahmoud Elhadi Mohand Hassan Dalia Abdelmonam Katarina Nisser Gunilla Hägg Terence Seemungal Fallon Lutchmansingh Liane Conyette Myriam Denguezli Hager Daldoul Zaki Boukheroufa Firas Chouikha Wahbi Belhaj Khalifa Attila Hancioglu Ismail Hanta Sedat Kuleci Ahmet Sinan Turkyilmaz Sema Umut Turgay Unalan Peter GJ Burney Hadia Azar Caron Amor Michael Tumilty Risha Dudhaiya A Sonia Buist Mary Ann McBurnie William M Vollmer Suzanne Gillespie Sean Sullivan Todd A Lee Kevin B Weiss Robert L Jensen Robert Crapo Paul Enright John Cain Rebecca Copeland Dana Hazen Jennifer Methvin Rana Ahmed Ewa Niżankowska-mogilnicka Sullian S Naval Jin-Ping Zheng Gunnar Gudmundsson Ben Knox-Brown Dhiraj Agarwal M Al Hajjaj L Safia Namarig Mohamed Elhassan Marwa Mohamed Mohamaden Sanjay K Juvekar Stefanni Nonna M Paraguas Anders Ørskov Rotevatn Alexandra SchwedaLinow Talant M. Sooronbaev Bermet M. Estebesova GJ Wesseling MariaTeresita N Reyes Flordeliza Sanchez MAl Ghobain Hasab Alrasoul Akasha Ahmed Osman Abdel Mu’is El Zain Ulrike SpetzNystrom GunMarie Lund
collection	DOAJ
description	Introduction Previous population-based studies, mainly from high-income countries, have shown that a higher forced vital capacity (FVC) is associated with a lower risk of developing cardiometabolic diseases. The aim of this study was to assess the longitudinal association between spirometry measures and the onset of cardiometabolic diseases across sites in low-income, middle-income and high-income countries.Methods The study population comprised 5916 individuals from 15 countries participating in the Burden of Obstructive Lung Disease baseline and follow-up assessments. Postbronchodilator forced expiratory volume in 1 s (FEV1), FVC and FEV1/FVC were measured at baseline. Participants who reported having doctor-diagnosed hypertension, diabetes, heart disease and stroke at follow-up but not at baseline were considered new cases of these diseases. The association between lung function and the onset of participant-reported cardiometabolic diseases was assessed in each site using regression models, and estimates were combined using random effects meta-analysis. Models were adjusted for sex, age, smoking, body mass index and educational level.Results Participants with greater per cent predicted FVC were less likely to have new-onset diabetes (OR per 10%=0.91, 95% CI 0.84 to 0.99), heart disease (OR per 10%=0.86, 95% CI 0.80 to 0.92) and stroke (OR per 10%=0.81, 95% CI 0.73 to 0.89) during the follow-up period (mean±SD 9.5±3.6 years). A greater percentage of FEV1 was associated with a lower risk of onset of heart disease and stroke. No significant association was found between FEV1/FVC and onset of reported cardiometabolic diseases, except for a higher risk of diabetes (OR per 10%=1.21, 95% CI 1.08 to 1.35) in participants with higher FEV1/FVC.Conclusions The findings of this study suggest that a low FVC is more important than a low FEV1/FVC as a risk factor for developing cardiometabolic diseases. The value of including FVC in risk score models to improve their precision in predicting the onset of cardiometabolic diseases should be explored.
format	Article
id	doaj-art-78a40140a4f44f2d85ebb56f692762df
institution	Kabale University
issn	2052-4439
language	English
publishDate	2025-01-01
publisher	BMJ Publishing Group
record_format	Article
series	BMJ Open Respiratory Research
spelling	doaj-art-78a40140a4f44f2d85ebb56f692762df2025-01-21T06:30:09ZengBMJ Publishing GroupBMJ Open Respiratory Research2052-44392025-01-0112110.1136/bmjresp-2024-002442Lung function and onset of cardiometabolic diseases in the longitudinal Burden of Obstructive Lung Disease study Andre F S Amaral0Andrzej PająkThorarinn Gislason1Syed Masud AhmedRain Jogi2Abdul RashidChristine JenkinsFiona McLeanJames Potts3Tobias WelteDali WangEric BatemanWen WangZafar FatmiKevin Mortimer4Christer Janson5Nanshan ZhongJoão CardosoParvaiz A KoulRune Nielsen6Nazrul IslamGraham Devereux7Andrei Malinovschi8Sanjay JuvekarTalant Sooronbaev9Berik EmilovBertrand MbatchouAyola Akim AdegnikaPadukudru Anand Mahesh10Kate HardakerEFM WoutersImed Harrabi11Amund GulsvikSundeep SalviMuhammad IrfanBill BrashierInga Sif ÓlafsdóttirZouhair TabkaPeter G J Burney12Jaymini PatelFilip MejzaDavid M ManninoMeriam Denguezli13Michael StudnickaAlthea Aquart-Stewart14Parvaiz Koul15Herve LawinAsaad Ahmed Nafees16Olayemi AwopejuGregory E Erhabor17Louisa GnatiucAli KocabasCristina BarbaraHasan HafiziAnila AlikoDonika BardhiHolta TafaNatasha ThanasiArian MeziniAlma TefericiDafina TodriJolanda NikollaRezarta KazasiHamid Hacene CherkaskiAmira BengraitTabarek HaddadIbtissem ZgaoulaMaamar GhitAbdelhamid RoubhiaSoumaya BoudraFeryal AtouiRanda YakoubiRachid BenaliAbdelghani BencheikhNadia Ait-KhaledGuy MarksTessa BirdPaola EspinelBrett ToelleTorkil DawesBernd LamprechtLea SchirhoferAkramul IslamShayla IslamQazi Shafayetul IslamMesbah Ul-HaqueTridib Roy ChowdhurySukantha Kumar ChatterjeeDulal MiaShyamal Chandra DasMizanur RahmanShahaz UddinNurul IslamLuiza KhatunMonira ParvinAbdul Awal KhanMaidul IslamArsene KpangonKarl KpossouGildas AgodokpessiPaul AyeloBenjamin FayomiAtongno Humphrey AshuWan C TanShengming LiuJiachun LuPixin RanYumin ZhouHendrik LajaKatrin UlstVappu ZobelToomas-Julius LillIsabelle BodemannHenning GeldmacherBryndis BenedikdtsdottirKristin JörundsdottirLovisa GudmundsdottirSigrun GudmundsdottirMahesh RaoSajjad MalikNissar A HakimUmar Hafiz KhanRohini ChowguleVasant ShetyeJonelle RaphaelRosel AlmedaMahesh TawdeRafiq TadviSunil KatkarMilind KadamRupesh DhanawadeUmesh GhurupSiddhi HirveSomnath SambhudasBharat ChaidharyMeera TambeSavita PingaleArati UmapArchana UmapNitin ShelarSampada DevchakkeSharda ChaudharySuvarna BondreSavita WalkeAshleshsa GawhaneAnil SapkalRupali ArgadeVijay GaikwadJyoti LondheSapna MadasAkosua Francia AikmanMeerim AkmatalievaSaadat UsenbaevaJypara KydyrovaEliza BostonovaUlan SheralievNuridin MarajapovNurgul ToktogulovaToktogul AzilovaGulnara BeishekeevaNasyikat DononbaevaAijamal TabyshovaWezzie NyapigotiErnest MwangokaMayamiko KambwiliMartha ChipetaGloria BandaSuzgo MkandawireJustice BandaLi-Cher LohSiti SholehahMohamed C BenjellounChakib NejjariMohamed ElbiazeKarima El RhaziDaniel ObasekiGregory ErhaborOlufemi AdewoleTina EndresenLene SvendsenAsaad A NafeesAysha ZahidieNatasha ShaukatMeesha IqbalLuisito F IdolorNorberto A FranciscoCamilo C RoaFernando G AyuyaoCecil Z TadyDaniel T TanSylvia Banal-YangVincent M BalanagRenato B DantesLourdes AmarilloLakan U BerratioLenora C FernandezGerard S GarciaTeresita S de GuiaThessa ReyesLeander P SimpaoJakub FreyRafal HaratPawel NastalekWojciech SkuchaAndrzej SzczeklikMagda TwardowskaFátima RodriguesHermínia DiasJoão AlmeidaMaria João MatosPaula SimãoMoutinho SantosReis FerreiraH AlorainyE El-HamadA HashiR DelaR FanuncioE DolorielI MarcianoAnamika JithooDesiree AdamsEdward BarnesJasper FreemanAnton HayesSipho HlengwaChristine JohannisenMariana KoopmanInnocentia LouwIna LudickAlta OlckersJohanna RyckJanita StorbeckKirthi GunasekeraRajitha WickremasingheAsma ElsonyHana A ElsadigNada Bakery OsmanBandar Salah NooryMonjda Awad MohamedSuhaiba KhalifaMahmoud ElhadiMohand HassanDalia AbdelmonamKatarina NisserGunilla HäggTerence SeemungalFallon LutchmansinghLiane ConyetteMyriam DenguezliHager DaldoulZaki BoukheroufaFiras ChouikhaWahbi Belhaj KhalifaAttila HanciogluIsmail HantaSedat KuleciAhmet Sinan TurkyilmazSema UmutTurgay UnalanPeter GJ BurneyHadia AzarCaron AmorMichael TumiltyRisha DudhaiyaA Sonia BuistMary Ann McBurnieWilliam M VollmerSuzanne GillespieSean SullivanTodd A LeeKevin B WeissRobert L JensenRobert CrapoPaul EnrightJohn CainRebecca CopelandDana HazenJennifer MethvinRana Ahmed18Ewa Niżankowska-mogilnickaSullian S NavalJin-Ping ZhengGunnar GudmundssonBen Knox-Brown19Dhiraj Agarwal20M Al HajjajL SafiaNamarig Mohamed ElhassanMarwa Mohamed MohamadenSanjay K Juvekar21Stefanni Nonna M Paraguas22Anders Ørskov Rotevatn23Alexandra SchwedaLinowTalant M. SooronbaevBermet M. EstebesovaGJ WesselingMariaTeresita N ReyesFlordeliza SanchezMAl GhobainHasab Alrasoul Akasha Ahmed OsmanAbdel Mu’is El ZainUlrike SpetzNystromGunMarie LundNational Heart and Lung Institute, Imperial College London, London, UKLandspitali University Hospital, Reykjavik, IcelandLung Clinic, Tartu University Hospital, Tartu, EstoniaNational Heart and Lung Institute, Imperial College London, London, UKUniversity of Cambridge, Cambridge, UKDepartment of Medical Sciences Respiratory Medicine, Uppsala Universitet, Uppsala, SwedenUniversity of Bergen, Bergen, NorwayClinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UKMedical Sciences, Uppsala University, Uppsala, SwedenDepartment of Respiratory Medicine, National Center for Cardiology and Internal Medicine, Bishkek, KyrgyzstanRespiratory Medicine, JSS Medical College and Hospital, Mysore, Karnataka, IndiaFaculté de Médecine, Sousse, TunisiaNational Heart and Lung Institute, Imperial College London, London, UKUniversite de Sousse Faculte de Medecine de Sousse, Sousse, TunisiaThe University of the West Indies, Kingston, JamaicaPulmonary Medicine, SKIMS, Srinagar, IndiaCommunity Health Sciences, Aga Khan University, Karachi, PakistanDepartment of Medicine, Obafemi Awolowo University, Ife, NigeriaThe Epidemiological Laboratory, Khartoum, SudanNational Heart and Lung Institute, Imperial College London, London, UKKEM Hospital Pune Research Centre, Pune, Maharashtra, IndiaIndependent Consultant, Pune, Maharashtra, IndiaPhilippine College of Chest Physicians, Manila, PhilippinesDepartment of Thoracic Medicine, Haukeland University Hospital, Bergen, NorwayIntroduction Previous population-based studies, mainly from high-income countries, have shown that a higher forced vital capacity (FVC) is associated with a lower risk of developing cardiometabolic diseases. The aim of this study was to assess the longitudinal association between spirometry measures and the onset of cardiometabolic diseases across sites in low-income, middle-income and high-income countries.Methods The study population comprised 5916 individuals from 15 countries participating in the Burden of Obstructive Lung Disease baseline and follow-up assessments. Postbronchodilator forced expiratory volume in 1 s (FEV1), FVC and FEV1/FVC were measured at baseline. Participants who reported having doctor-diagnosed hypertension, diabetes, heart disease and stroke at follow-up but not at baseline were considered new cases of these diseases. The association between lung function and the onset of participant-reported cardiometabolic diseases was assessed in each site using regression models, and estimates were combined using random effects meta-analysis. Models were adjusted for sex, age, smoking, body mass index and educational level.Results Participants with greater per cent predicted FVC were less likely to have new-onset diabetes (OR per 10%=0.91, 95% CI 0.84 to 0.99), heart disease (OR per 10%=0.86, 95% CI 0.80 to 0.92) and stroke (OR per 10%=0.81, 95% CI 0.73 to 0.89) during the follow-up period (mean±SD 9.5±3.6 years). A greater percentage of FEV1 was associated with a lower risk of onset of heart disease and stroke. No significant association was found between FEV1/FVC and onset of reported cardiometabolic diseases, except for a higher risk of diabetes (OR per 10%=1.21, 95% CI 1.08 to 1.35) in participants with higher FEV1/FVC.Conclusions The findings of this study suggest that a low FVC is more important than a low FEV1/FVC as a risk factor for developing cardiometabolic diseases. The value of including FVC in risk score models to improve their precision in predicting the onset of cardiometabolic diseases should be explored.https://bmjopenrespres.bmj.com/content/12/1/e002442.full
spellingShingle	Andre F S Amaral Andrzej Pająk Thorarinn Gislason Syed Masud Ahmed Rain Jogi Abdul Rashid Christine Jenkins Fiona McLean James Potts Tobias Welte Dali Wang Eric Bateman Wen Wang Zafar Fatmi Kevin Mortimer Christer Janson Nanshan Zhong João Cardoso Parvaiz A Koul Rune Nielsen Nazrul Islam Graham Devereux Andrei Malinovschi Sanjay Juvekar Talant Sooronbaev Berik Emilov Bertrand Mbatchou Ayola Akim Adegnika Padukudru Anand Mahesh Kate Hardaker EFM Wouters Imed Harrabi Amund Gulsvik Sundeep Salvi Muhammad Irfan Bill Brashier Inga Sif Ólafsdóttir Zouhair Tabka Peter G J Burney Jaymini Patel Filip Mejza David M Mannino Meriam Denguezli Michael Studnicka Althea Aquart-Stewart Parvaiz Koul Herve Lawin Asaad Ahmed Nafees Olayemi Awopeju Gregory E Erhabor Louisa Gnatiuc Ali Kocabas Cristina Barbara Hasan Hafizi Anila Aliko Donika Bardhi Holta Tafa Natasha Thanasi Arian Mezini Alma Teferici Dafina Todri Jolanda Nikolla Rezarta Kazasi Hamid Hacene Cherkaski Amira Bengrait Tabarek Haddad Ibtissem Zgaoula Maamar Ghit Abdelhamid Roubhia Soumaya Boudra Feryal Atoui Randa Yakoubi Rachid Benali Abdelghani Bencheikh Nadia Ait-Khaled Guy Marks Tessa Bird Paola Espinel Brett Toelle Torkil Dawes Bernd Lamprecht Lea Schirhofer Akramul Islam Shayla Islam Qazi Shafayetul Islam Mesbah Ul-Haque Tridib Roy Chowdhury Sukantha Kumar Chatterjee Dulal Mia Shyamal Chandra Das Mizanur Rahman Shahaz Uddin Nurul Islam Luiza Khatun Monira Parvin Abdul Awal Khan Maidul Islam Arsene Kpangon Karl Kpossou Gildas Agodokpessi Paul Ayelo Benjamin Fayomi Atongno Humphrey Ashu Wan C Tan Shengming Liu Jiachun Lu Pixin Ran Yumin Zhou Hendrik Laja Katrin Ulst Vappu Zobel Toomas-Julius Lill Isabelle Bodemann Henning Geldmacher Bryndis Benedikdtsdottir Kristin Jörundsdottir Lovisa Gudmundsdottir Sigrun Gudmundsdottir Mahesh Rao Sajjad Malik Nissar A Hakim Umar Hafiz Khan Rohini Chowgule Vasant Shetye Jonelle Raphael Rosel Almeda Mahesh Tawde Rafiq Tadvi Sunil Katkar Milind Kadam Rupesh Dhanawade Umesh Ghurup Siddhi Hirve Somnath Sambhudas Bharat Chaidhary Meera Tambe Savita Pingale Arati Umap Archana Umap Nitin Shelar Sampada Devchakke Sharda Chaudhary Suvarna Bondre Savita Walke Ashleshsa Gawhane Anil Sapkal Rupali Argade Vijay Gaikwad Jyoti Londhe Sapna Madas Akosua Francia Aikman Meerim Akmatalieva Saadat Usenbaeva Jypara Kydyrova Eliza Bostonova Ulan Sheraliev Nuridin Marajapov Nurgul Toktogulova Toktogul Azilova Gulnara Beishekeeva Nasyikat Dononbaeva Aijamal Tabyshova Wezzie Nyapigoti Ernest Mwangoka Mayamiko Kambwili Martha Chipeta Gloria Banda Suzgo Mkandawire Justice Banda Li-Cher Loh Siti Sholehah Mohamed C Benjelloun Chakib Nejjari Mohamed Elbiaze Karima El Rhazi Daniel Obaseki Gregory Erhabor Olufemi Adewole Tina Endresen Lene Svendsen Asaad A Nafees Aysha Zahidie Natasha Shaukat Meesha Iqbal Luisito F Idolor Norberto A Francisco Camilo C Roa Fernando G Ayuyao Cecil Z Tady Daniel T Tan Sylvia Banal-Yang Vincent M Balanag Renato B Dantes Lourdes Amarillo Lakan U Berratio Lenora C Fernandez Gerard S Garcia Teresita S de Guia Thessa Reyes Leander P Simpao Jakub Frey Rafal Harat Pawel Nastalek Wojciech Skucha Andrzej Szczeklik Magda Twardowska Fátima Rodrigues Hermínia Dias João Almeida Maria João Matos Paula Simão Moutinho Santos Reis Ferreira H Alorainy E El-Hamad A Hashi R Dela R Fanuncio E Doloriel I Marciano Anamika Jithoo Desiree Adams Edward Barnes Jasper Freeman Anton Hayes Sipho Hlengwa Christine Johannisen Mariana Koopman Innocentia Louw Ina Ludick Alta Olckers Johanna Ryck Janita Storbeck Kirthi Gunasekera Rajitha Wickremasinghe Asma Elsony Hana A Elsadig Nada Bakery Osman Bandar Salah Noory Monjda Awad Mohamed Suhaiba Khalifa Mahmoud Elhadi Mohand Hassan Dalia Abdelmonam Katarina Nisser Gunilla Hägg Terence Seemungal Fallon Lutchmansingh Liane Conyette Myriam Denguezli Hager Daldoul Zaki Boukheroufa Firas Chouikha Wahbi Belhaj Khalifa Attila Hancioglu Ismail Hanta Sedat Kuleci Ahmet Sinan Turkyilmaz Sema Umut Turgay Unalan Peter GJ Burney Hadia Azar Caron Amor Michael Tumilty Risha Dudhaiya A Sonia Buist Mary Ann McBurnie William M Vollmer Suzanne Gillespie Sean Sullivan Todd A Lee Kevin B Weiss Robert L Jensen Robert Crapo Paul Enright John Cain Rebecca Copeland Dana Hazen Jennifer Methvin Rana Ahmed Ewa Niżankowska-mogilnicka Sullian S Naval Jin-Ping Zheng Gunnar Gudmundsson Ben Knox-Brown Dhiraj Agarwal M Al Hajjaj L Safia Namarig Mohamed Elhassan Marwa Mohamed Mohamaden Sanjay K Juvekar Stefanni Nonna M Paraguas Anders Ørskov Rotevatn Alexandra SchwedaLinow Talant M. Sooronbaev Bermet M. Estebesova GJ Wesseling MariaTeresita N Reyes Flordeliza Sanchez MAl Ghobain Hasab Alrasoul Akasha Ahmed Osman Abdel Mu’is El Zain Ulrike SpetzNystrom GunMarie Lund Lung function and onset of cardiometabolic diseases in the longitudinal Burden of Obstructive Lung Disease study BMJ Open Respiratory Research
title	Lung function and onset of cardiometabolic diseases in the longitudinal Burden of Obstructive Lung Disease study
title_full	Lung function and onset of cardiometabolic diseases in the longitudinal Burden of Obstructive Lung Disease study
title_fullStr	Lung function and onset of cardiometabolic diseases in the longitudinal Burden of Obstructive Lung Disease study
title_full_unstemmed	Lung function and onset of cardiometabolic diseases in the longitudinal Burden of Obstructive Lung Disease study
title_short	Lung function and onset of cardiometabolic diseases in the longitudinal Burden of Obstructive Lung Disease study
title_sort	lung function and onset of cardiometabolic diseases in the longitudinal burden of obstructive lung disease study
url	https://bmjopenrespres.bmj.com/content/12/1/e002442.full
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lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT jyparakydyrova lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT elizabostonova lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT ulansheraliev lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT nuridinmarajapov lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT nurgultoktogulova lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT toktogulazilova lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT gulnarabeishekeeva lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT nasyikatdononbaeva lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT aijamaltabyshova lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT wezzienyapigoti lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT ernestmwangoka lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT mayamikokambwili lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT marthachipeta lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT gloriabanda lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT suzgomkandawire lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT justicebanda lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT licherloh lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT sitisholehah lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT mohamedcbenjelloun lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT chakibnejjari lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT mohamedelbiaze lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT karimaelrhazi lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT danielobaseki lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT gregoryerhabor lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT olufemiadewole lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT tinaendresen lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT lenesvendsen lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT asaadanafees lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT ayshazahidie lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT natashashaukat lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT meeshaiqbal lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT luisitofidolor lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT norbertoafrancisco lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT camilocroa lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT fernandogayuyao lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT cecilztady lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT danielttan lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT sylviabanalyang lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT vincentmbalanag lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT renatobdantes lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT lourdesamarillo lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT lakanuberratio lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT lenoracfernandez lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT gerardsgarcia lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT teresitasdeguia lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT thessareyes lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT leanderpsimpao lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT jakubfrey lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT rafalharat lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT pawelnastalek lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT wojciechskucha lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT andrzejszczeklik lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT magdatwardowska lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT fatimarodrigues lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT herminiadias lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT joaoalmeida lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT mariajoaomatos lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT paulasimao lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT moutinhosantos lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT reisferreira lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT halorainy lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT eelhamad lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT ahashi lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT rdela lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT rfanuncio lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT edoloriel lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT imarciano lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT anamikajithoo lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT desireeadams lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT edwardbarnes lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT jasperfreeman lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT antonhayes lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT siphohlengwa lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT christinejohannisen lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT marianakoopman lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT innocentialouw lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT inaludick lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT altaolckers lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT johannaryck lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT janitastorbeck lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT kirthigunasekera lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT rajithawickremasinghe lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT asmaelsony lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT hanaaelsadig lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT nadabakeryosman lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT bandarsalahnoory lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT monjdaawadmohamed lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT suhaibakhalifa lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT mahmoudelhadi lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT mohandhassan lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT daliaabdelmonam lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT katarinanisser lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT gunillahagg lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT terenceseemungal lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT fallonlutchmansingh lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT lianeconyette lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT myriamdenguezli lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT hagerdaldoul lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT zakiboukheroufa lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT firaschouikha lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT wahbibelhajkhalifa lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT attilahancioglu lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT ismailhanta lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT sedatkuleci lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT ahmetsinanturkyilmaz lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT semaumut lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT turgayunalan lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT petergjburney lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT hadiaazar lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT caronamor lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT michaeltumilty lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT rishadudhaiya lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT asoniabuist lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT maryannmcburnie lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT williammvollmer lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT suzannegillespie lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT seansullivan lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT toddalee lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT kevinbweiss lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT robertljensen lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT robertcrapo lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT paulenright lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT johncain lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT rebeccacopeland lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT danahazen lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT jennifermethvin lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT ranaahmed lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT ewanizankowskamogilnicka lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT sulliansnaval lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT jinpingzheng lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT gunnargudmundsson lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT benknoxbrown lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT dhirajagarwal lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT malhajjaj lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT lsafia lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT namarigmohamedelhassan lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT marwamohamedmohamaden lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT sanjaykjuvekar lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT stefanninonnamparaguas lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT andersørskovrotevatn lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT alexandraschwedalinow lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT talantmsooronbaev lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT bermetmestebesova lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT gjwesseling lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT mariateresitanreyes lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT flordelizasanchez lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT malghobain lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT hasabalrasoulakashaahmedosman lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT abdelmuiselzain lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT ulrikespetznystrom lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy AT gunmarielund lungfunctionandonsetofcardiometabolicdiseasesinthelongitudinalburdenofobstructivelungdiseasestudy

Lung function and onset of cardiometabolic diseases in the longitudinal Burden of Obstructive Lung Disease study

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