1H MRS-based metabolite changes at ventral respiratory control centers of the medulla oblongata following administration of morphine in wild-type and GIRK2 mutant mice

1H MRS-based metabolite changes at ventral respiratory control centers of the medulla oblongata following administration of morphine in wild-type and GIRK2 mutant mice

Respiratory depression is the leading cause of death in opioid overdose and is closely associated with the development of tolerance following repeated morphine use. However, the neurochemical adaptations in brainstem regions that regulate breathing, particularly under chronic opioid exposure, remain...

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Bibliographic Details
Main Authors: Ozra Dehkordi, Stephen Lin, Safia Mohamud, Richard M. Millis, Paul C. Wang
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Current Research in Physiology
Subjects:
1H MRS
Pre-bötzinger
Morphine
GIRK2 channels
Online Access:http://www.sciencedirect.com/science/article/pii/S2665944125000094
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