Targeting Nrf2/KEAP1 signaling pathway using bioactive compounds to combat mastitis
Mastitis is a common inflammation of mammary glands that has a significantly impact on dairy production and animal health, causing considerable economic burdens worldwide. Elevated reactive oxygen species (ROS) followed by oxidative stress, apoptosis, inflammatory changes and suppressed immunity are...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1425901/full |
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| author | Muhammad Zahoor Khan Liangliang Li Yandong Zhan Huang Binjiang Xiaotong Liu Xiyan Kou Adnan Khan Abdul Qadeer Qudrat Ullah Khalid J. Alzahrani Tongtong Wang Changfa Wang Muhammad Zahoor |
| author_facet | Muhammad Zahoor Khan Liangliang Li Yandong Zhan Huang Binjiang Xiaotong Liu Xiyan Kou Adnan Khan Abdul Qadeer Qudrat Ullah Khalid J. Alzahrani Tongtong Wang Changfa Wang Muhammad Zahoor |
| author_sort | Muhammad Zahoor Khan |
| collection | DOAJ |
| description | Mastitis is a common inflammation of mammary glands that has a significantly impact on dairy production and animal health, causing considerable economic burdens worldwide. Elevated reactive oxygen species (ROS) followed by oxidative stress, apoptosis, inflammatory changes and suppressed immunity are considered the key biomarkers observed during mastitis. The Nrf2/KEAP1 signaling pathway plays a critical role in regulating antioxidant responses and cellular defense mechanisms. When activated by bioactive compound treatment, Nrf2 translocates to the nucleus and induces the expression of its target genes to exert antioxidant responses. This reduces pathogen-induced oxidative stress and inflammation by inhibiting NF-kB signaling in the mammary glands, one of the prominent pro-inflammatory signaling pathway. Here, we summarize recent studies to highlight the therapeutic potential of Nrf2/KEAP1 pathway in the prevention and treatment of mastitis. Collectively this review article aims to explore the potential of bioactive compounds in mitigating mastitis by targeting the Nrf2/KEAP1 signaling pathway. |
| format | Article |
| id | doaj-art-789a57791bcf494ba6e449f3f39cf59b |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-789a57791bcf494ba6e449f3f39cf59b2025-02-07T06:49:24ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.14259011425901Targeting Nrf2/KEAP1 signaling pathway using bioactive compounds to combat mastitisMuhammad Zahoor Khan0Liangliang Li1Yandong Zhan2Huang Binjiang3Xiaotong Liu4Xiyan Kou5Adnan Khan6Abdul Qadeer7Qudrat Ullah8Khalid J. Alzahrani9Tongtong Wang10Changfa Wang11Muhammad Zahoor12Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Liaocheng University, Liaocheng, ChinaLiaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Liaocheng University, Liaocheng, ChinaLiaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Liaocheng University, Liaocheng, ChinaLiaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Liaocheng University, Liaocheng, ChinaLiaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Liaocheng University, Liaocheng, ChinaLiaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Liaocheng University, Liaocheng, ChinaGenome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, ChinaDepartment of Cell Biology, School of Life Sciences, Central South University, Changsha, ChinaDepartment of Theriogenology, Faculty of Veterinary and Animal Sciences, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Punjab, PakistanDepartment of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi ArabiaLiaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Liaocheng University, Liaocheng, ChinaLiaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding, Liaocheng University, Liaocheng, ChinaDepartment of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, NorwayMastitis is a common inflammation of mammary glands that has a significantly impact on dairy production and animal health, causing considerable economic burdens worldwide. Elevated reactive oxygen species (ROS) followed by oxidative stress, apoptosis, inflammatory changes and suppressed immunity are considered the key biomarkers observed during mastitis. The Nrf2/KEAP1 signaling pathway plays a critical role in regulating antioxidant responses and cellular defense mechanisms. When activated by bioactive compound treatment, Nrf2 translocates to the nucleus and induces the expression of its target genes to exert antioxidant responses. This reduces pathogen-induced oxidative stress and inflammation by inhibiting NF-kB signaling in the mammary glands, one of the prominent pro-inflammatory signaling pathway. Here, we summarize recent studies to highlight the therapeutic potential of Nrf2/KEAP1 pathway in the prevention and treatment of mastitis. Collectively this review article aims to explore the potential of bioactive compounds in mitigating mastitis by targeting the Nrf2/KEAP1 signaling pathway.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1425901/fullmastitisinflammationimmunityoxidative stressantioxidantsbioactive compounds |
| spellingShingle | Muhammad Zahoor Khan Liangliang Li Yandong Zhan Huang Binjiang Xiaotong Liu Xiyan Kou Adnan Khan Abdul Qadeer Qudrat Ullah Khalid J. Alzahrani Tongtong Wang Changfa Wang Muhammad Zahoor Targeting Nrf2/KEAP1 signaling pathway using bioactive compounds to combat mastitis Frontiers in Immunology mastitis inflammation immunity oxidative stress antioxidants bioactive compounds |
| title | Targeting Nrf2/KEAP1 signaling pathway using bioactive compounds to combat mastitis |
| title_full | Targeting Nrf2/KEAP1 signaling pathway using bioactive compounds to combat mastitis |
| title_fullStr | Targeting Nrf2/KEAP1 signaling pathway using bioactive compounds to combat mastitis |
| title_full_unstemmed | Targeting Nrf2/KEAP1 signaling pathway using bioactive compounds to combat mastitis |
| title_short | Targeting Nrf2/KEAP1 signaling pathway using bioactive compounds to combat mastitis |
| title_sort | targeting nrf2 keap1 signaling pathway using bioactive compounds to combat mastitis |
| topic | mastitis inflammation immunity oxidative stress antioxidants bioactive compounds |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1425901/full |
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