Randomized Clinical Trial Comparing The Effect Of Oral Rehydration Therapy With And Without Racecadotril In The Management Of Acute Diarrhea In Children
Objective: This study aimed to investigate the beneficial effect of racecadotril in children with acute diarrheal illness. Methods: This randomized case-control study was conducted at Watim General Hospital over four months from April to July 2023. A total of 120 children aged 3 months to 12 year...
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Rawalpindi Medical University
2023-12-01
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| Series: | Journal of Rawalpindi Medical College |
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| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/2365 |
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| author | Sughra Zulfiqar Hifza Zeb Nadia Mumtaz Ammara Musthaq Khan Taimur Khalil Sheikh Tariq Saeed |
| author_facet | Sughra Zulfiqar Hifza Zeb Nadia Mumtaz Ammara Musthaq Khan Taimur Khalil Sheikh Tariq Saeed |
| author_sort | Sughra Zulfiqar |
| collection | DOAJ |
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Objective: This study aimed to investigate the beneficial effect of racecadotril in children with acute diarrheal illness.
Methods: This randomized case-control study was conducted at Watim General Hospital over four months from April to July 2023. A total of 120 children aged 3 months to 12 years with acute diarrhoea were included and randomly allocated to two groups. Group A (n=60) received standard treatment with oral rehydration therapy, while Group B (n=60) received oral rehydration therapy, zinc, probiotics, and racecadotril. The primary outcome measured was the mean duration of illness, and the secondary outcome was the number of stools 48 hours after the start of treatment. Data were collected using a pre-designed proforma and analyzed using SPSS version 24.
Results: The study population had an average age of 50.35±41.52 months, with equal gender distribution. The mean duration of illness in Group A was 2.72±1.34 days, while in Group B, it was 2.70±1.29 days. There was no statistically significant difference in the mean duration of illness between the two groups (p=0.945).
Conclusion: This study did not demonstrate a significant reduction in the mean duration of illness for children with acute gastroenteritis using standard treatment with or without racecadotril. Further investigations and large-scale studies may be needed to establish the efficacy of racecadotril in the management of acute diarrhoea in children.
Keywords: Acute diarrhoea, ORS, Racecadotril.
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| format | Article |
| id | doaj-art-78851eb08c4e45bba1d241e5f28c0937 |
| institution | Kabale University |
| issn | 1683-3562 1683-3570 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Rawalpindi Medical University |
| record_format | Article |
| series | Journal of Rawalpindi Medical College |
| spelling | doaj-art-78851eb08c4e45bba1d241e5f28c09372025-02-06T08:39:46ZengRawalpindi Medical UniversityJournal of Rawalpindi Medical College1683-35621683-35702023-12-0127410.37939/jrmc.v27i4.2365Randomized Clinical Trial Comparing The Effect Of Oral Rehydration Therapy With And Without Racecadotril In The Management Of Acute Diarrhea In Children Sughra Zulfiqar0Hifza Zeb1Nadia Mumtaz2Ammara Musthaq Khan3Taimur Khalil Sheikh4Tariq Saeed5Watim Medical CollegeDHQ Hospital, Attock Holy Family HospitalRiphah International HospitalAl-Nafees Medical CollegeWatim Medical College Objective: This study aimed to investigate the beneficial effect of racecadotril in children with acute diarrheal illness. Methods: This randomized case-control study was conducted at Watim General Hospital over four months from April to July 2023. A total of 120 children aged 3 months to 12 years with acute diarrhoea were included and randomly allocated to two groups. Group A (n=60) received standard treatment with oral rehydration therapy, while Group B (n=60) received oral rehydration therapy, zinc, probiotics, and racecadotril. The primary outcome measured was the mean duration of illness, and the secondary outcome was the number of stools 48 hours after the start of treatment. Data were collected using a pre-designed proforma and analyzed using SPSS version 24. Results: The study population had an average age of 50.35±41.52 months, with equal gender distribution. The mean duration of illness in Group A was 2.72±1.34 days, while in Group B, it was 2.70±1.29 days. There was no statistically significant difference in the mean duration of illness between the two groups (p=0.945). Conclusion: This study did not demonstrate a significant reduction in the mean duration of illness for children with acute gastroenteritis using standard treatment with or without racecadotril. Further investigations and large-scale studies may be needed to establish the efficacy of racecadotril in the management of acute diarrhoea in children. Keywords: Acute diarrhoea, ORS, Racecadotril. https://www.journalrmc.com/index.php/JRMC/article/view/2365Acute diarrhea, ORS, Racecadotril |
| spellingShingle | Sughra Zulfiqar Hifza Zeb Nadia Mumtaz Ammara Musthaq Khan Taimur Khalil Sheikh Tariq Saeed Randomized Clinical Trial Comparing The Effect Of Oral Rehydration Therapy With And Without Racecadotril In The Management Of Acute Diarrhea In Children Journal of Rawalpindi Medical College Acute diarrhea, ORS, Racecadotril |
| title | Randomized Clinical Trial Comparing The Effect Of Oral Rehydration Therapy With And Without Racecadotril In The Management Of Acute Diarrhea In Children |
| title_full | Randomized Clinical Trial Comparing The Effect Of Oral Rehydration Therapy With And Without Racecadotril In The Management Of Acute Diarrhea In Children |
| title_fullStr | Randomized Clinical Trial Comparing The Effect Of Oral Rehydration Therapy With And Without Racecadotril In The Management Of Acute Diarrhea In Children |
| title_full_unstemmed | Randomized Clinical Trial Comparing The Effect Of Oral Rehydration Therapy With And Without Racecadotril In The Management Of Acute Diarrhea In Children |
| title_short | Randomized Clinical Trial Comparing The Effect Of Oral Rehydration Therapy With And Without Racecadotril In The Management Of Acute Diarrhea In Children |
| title_sort | randomized clinical trial comparing the effect of oral rehydration therapy with and without racecadotril in the management of acute diarrhea in children |
| topic | Acute diarrhea, ORS, Racecadotril |
| url | https://www.journalrmc.com/index.php/JRMC/article/view/2365 |
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