Comparison of First- and Second-Generation Drug-Eluting Stents in Patients with Acute Myocardial Infarction and Prediabetes Based on the Hemoglobin A1c Level
Objective. To compare major clinical outcomes after successful percutaneous coronary intervention (PCI) with first-generation (1G) drug-eluting stents (DES) and second-generation (2G) DES in patients with acute myocardial infarction (AMI) and prediabetes. Background. Patients with prediabetes are as...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Interventional Cardiology |
| Online Access: | http://dx.doi.org/10.1155/2020/1710439 |
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| author | Yong Hoon Kim Ae-Young Her Myung Ho Jeong Byeong-Keuk Kim Sung-Jin Hong Seunghwan Kim Chul-Min Ahn Jung-Sun Kim Young-Guk Ko Donghoon Choi Myeong-Ki Hong Yangsoo Jang |
| author_facet | Yong Hoon Kim Ae-Young Her Myung Ho Jeong Byeong-Keuk Kim Sung-Jin Hong Seunghwan Kim Chul-Min Ahn Jung-Sun Kim Young-Guk Ko Donghoon Choi Myeong-Ki Hong Yangsoo Jang |
| author_sort | Yong Hoon Kim |
| collection | DOAJ |
| description | Objective. To compare major clinical outcomes after successful percutaneous coronary intervention (PCI) with first-generation (1G) drug-eluting stents (DES) and second-generation (2G) DES in patients with acute myocardial infarction (AMI) and prediabetes. Background. Patients with prediabetes are associated with an increased incidence of coronary artery disease. The relative superiority of 1G- and 2G-DES in these patients is not well established. Methods. A total of 4997 patients with AMI and prediabetes were divided into two groups: the 1D-DES group (n = 726) and the 2G-DES group (n = 4271). The primary outcomes were the patient-oriented composite outcomes (POCOs) defined as all-cause death, recurrent myocardial infarction (Re-MI), and any disease revascularization at 2-year follow-up. The secondary outcome was probable or definite stent thrombosis (ST). Results. After propensity score-matching (PSM) analysis, two PSM groups (698 pairs, n = 1396, C-statistics = 0.725) were generated. The cumulative incidence rates of POCOs (hazard ratio (HR): 1.467; 95% confidence interval (CI): 1.068–2.015; p=0.018), any disease revascularization (HR: 2.259; 95% CI: 1.397–3.654; p=0.001), and ST (HR: 4.361; 95% CI: 1.243–15.30; p=0.021) in the 1G-DES group were significantly higher than those in the 2G-DES group. However, the cumulative incidence rates of all-cause death, cardiac death, and Re-MI were similar between the two groups. Conclusions. In patients with AMI and prediabetes, 2G-DES implantation was more efficacious than 1G-DES implantation over a 2-year follow-up period. However, further studies are needed to confirm these results. |
| format | Article |
| id | doaj-art-788474695dbc4e968fc4911e468ae8e5 |
| institution | Kabale University |
| issn | 0896-4327 1540-8183 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Interventional Cardiology |
| spelling | doaj-art-788474695dbc4e968fc4911e468ae8e52025-02-03T06:46:34ZengWileyJournal of Interventional Cardiology0896-43271540-81832020-01-01202010.1155/2020/17104391710439Comparison of First- and Second-Generation Drug-Eluting Stents in Patients with Acute Myocardial Infarction and Prediabetes Based on the Hemoglobin A1c LevelYong Hoon Kim0Ae-Young Her1Myung Ho Jeong2Byeong-Keuk Kim3Sung-Jin Hong4Seunghwan Kim5Chul-Min Ahn6Jung-Sun Kim7Young-Guk Ko8Donghoon Choi9Myeong-Ki Hong10Yangsoo Jang11Division of Cardiology, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Republic of KoreaDivision of Cardiology, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Republic of KoreaDepartment of Cardiology, Chonnam National University Hospital, Gwangju, Republic of KoreaDivision of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seuol, Republic of KoreaDivision of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seuol, Republic of KoreaDivision of Cardiology, Inje University College of Medicine, Haeundae Paik Hospital, Busan, Republic of KoreaDivision of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seuol, Republic of KoreaDivision of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seuol, Republic of KoreaDivision of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seuol, Republic of KoreaDivision of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seuol, Republic of KoreaDivision of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seuol, Republic of KoreaDivision of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seuol, Republic of KoreaObjective. To compare major clinical outcomes after successful percutaneous coronary intervention (PCI) with first-generation (1G) drug-eluting stents (DES) and second-generation (2G) DES in patients with acute myocardial infarction (AMI) and prediabetes. Background. Patients with prediabetes are associated with an increased incidence of coronary artery disease. The relative superiority of 1G- and 2G-DES in these patients is not well established. Methods. A total of 4997 patients with AMI and prediabetes were divided into two groups: the 1D-DES group (n = 726) and the 2G-DES group (n = 4271). The primary outcomes were the patient-oriented composite outcomes (POCOs) defined as all-cause death, recurrent myocardial infarction (Re-MI), and any disease revascularization at 2-year follow-up. The secondary outcome was probable or definite stent thrombosis (ST). Results. After propensity score-matching (PSM) analysis, two PSM groups (698 pairs, n = 1396, C-statistics = 0.725) were generated. The cumulative incidence rates of POCOs (hazard ratio (HR): 1.467; 95% confidence interval (CI): 1.068–2.015; p=0.018), any disease revascularization (HR: 2.259; 95% CI: 1.397–3.654; p=0.001), and ST (HR: 4.361; 95% CI: 1.243–15.30; p=0.021) in the 1G-DES group were significantly higher than those in the 2G-DES group. However, the cumulative incidence rates of all-cause death, cardiac death, and Re-MI were similar between the two groups. Conclusions. In patients with AMI and prediabetes, 2G-DES implantation was more efficacious than 1G-DES implantation over a 2-year follow-up period. However, further studies are needed to confirm these results.http://dx.doi.org/10.1155/2020/1710439 |
| spellingShingle | Yong Hoon Kim Ae-Young Her Myung Ho Jeong Byeong-Keuk Kim Sung-Jin Hong Seunghwan Kim Chul-Min Ahn Jung-Sun Kim Young-Guk Ko Donghoon Choi Myeong-Ki Hong Yangsoo Jang Comparison of First- and Second-Generation Drug-Eluting Stents in Patients with Acute Myocardial Infarction and Prediabetes Based on the Hemoglobin A1c Level Journal of Interventional Cardiology |
| title | Comparison of First- and Second-Generation Drug-Eluting Stents in Patients with Acute Myocardial Infarction and Prediabetes Based on the Hemoglobin A1c Level |
| title_full | Comparison of First- and Second-Generation Drug-Eluting Stents in Patients with Acute Myocardial Infarction and Prediabetes Based on the Hemoglobin A1c Level |
| title_fullStr | Comparison of First- and Second-Generation Drug-Eluting Stents in Patients with Acute Myocardial Infarction and Prediabetes Based on the Hemoglobin A1c Level |
| title_full_unstemmed | Comparison of First- and Second-Generation Drug-Eluting Stents in Patients with Acute Myocardial Infarction and Prediabetes Based on the Hemoglobin A1c Level |
| title_short | Comparison of First- and Second-Generation Drug-Eluting Stents in Patients with Acute Myocardial Infarction and Prediabetes Based on the Hemoglobin A1c Level |
| title_sort | comparison of first and second generation drug eluting stents in patients with acute myocardial infarction and prediabetes based on the hemoglobin a1c level |
| url | http://dx.doi.org/10.1155/2020/1710439 |
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