Impact of 3D cell culture hydrogels derived from basement membrane extracts or nanofibrillar cellulose on CAR-T cell activation

Impact of 3D cell culture hydrogels derived from basement membrane extracts or nanofibrillar cellulose on CAR-T cell activation

Summary: Hydrogel-based 3D culture systems are increasingly used for preclinical evaluation of cell-based immunotherapies, including chimeric antigen receptor T (CAR-T) cells. However, hydrogel properties can influence T cell behavior, potentially affecting interpretation of immunotherapy studies. W...

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Bibliographic Details
Main Authors: Sonia Aristin Revilla, Alessandro Cutilli, Eugenia Cambiaso, Dedeke Rockx-Brouwer, Cynthia Lisanne Frederiks, Marc Falandt, Riccardo Levato, Onno Kranenburg, Caroline A. Lindemans, Paul James Coffer, Victor Peperzak, Enric Mocholi, Marta Cuenca
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:iScience
Subjects:
Biological sciences
Immune response
Cell biology
Materials science
Biomaterials
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225014956
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