Injectable Self-Assembling Procyanidin Nanospheres for Effective Osteoarthritis Treatment
Guangjie Li,1,2,* Fei He,2,* Jianbao Feng,3 Ge Xu,1 Chengye Wu,1 Yufei Qiao,1 Yang Liu,3 Hanlin Chen,1 Pengcheng Du,4 Jizeng Wang2 1The First Hospital of Lanzhou University, Lanzhou, Gansu Province, People’s Republic of China; 2College of Civil Engineering and Mechanics, Lanzhou Univ...
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Dove Medical Press
2025-01-01
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| author | Li G He F Feng J Xu G Wu C Qiao Y Liu Y Chen H Du P Wang J |
| author_facet | Li G He F Feng J Xu G Wu C Qiao Y Liu Y Chen H Du P Wang J |
| author_sort | Li G |
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| description | Guangjie Li,1,2,* Fei He,2,* Jianbao Feng,3 Ge Xu,1 Chengye Wu,1 Yufei Qiao,1 Yang Liu,3 Hanlin Chen,1 Pengcheng Du,4 Jizeng Wang2 1The First Hospital of Lanzhou University, Lanzhou, Gansu Province, People’s Republic of China; 2College of Civil Engineering and Mechanics, Lanzhou University, Lanzhou, Gansu Province, People’s Republic of China; 3Hospital of Stomatology, Lanzhou University, Lanzhou, Gansu Province, People’s Republic of China; 4College of Chemistry and Chemical Engineering, Lanzhou University, Gansu Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jizeng Wang, Email jzwang@lzu.edu.cnBackground: Osteoarthritis (OA), a prevalent joint disease, causes immense suffering to thousands of patients, impairing their mobility and diminishing their quality of life. Current treatment methods primarily rely on analgesics or anti-inflammatory drugs to alleviate symptoms but fail to achieve the desired therapeutic outcome.Methods: To better realize therapeutic effects of OA, procyanidins (PAs), as a type of plant flavonoids with strong antioxidant and anti-inflammatory activities, were designed to self-assembly with well-dispersible Pluronic F127 (PF127) through the hydrogen-bond interaction to present an injectable, biocompatibility PA nanospheres.Results: These nanospheres significantly increased the cell viability in mouse L929 fibroblasts and ADTC5 chondrocytes compared with unassembled PAs. In addition, the self-assembling PAs/PF127 nanospheres enhanced the protein expression of collagen (COL1A1 and COL3A1) in fibroblasts, and the expression of glycosaminoglycan and COL2A1 was also higher than unassembled PAs in chondrocytes, this heralded the potential to achieve OA repair strategies at the cellular level. In an enzymolysis model of rat OA, PAs/PF127 nanospheres significantly reduce joint space swelling in the early stages of cartilage destruction and accelerate the formation of subchondral bone and cartilaginous surface.Implication: This study offers valuable insights into the preparation of novel PA nanospheres for effective repair of OA.Keywords: procyanidin, self-assembling nanospheres, injectable, osteoarthritis treatment |
| format | Article |
| id | doaj-art-78792c44dcf6479682d7b2a6123f513a |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| series | International Journal of Nanomedicine |
| spelling | doaj-art-78792c44dcf6479682d7b2a6123f513a2025-01-30T18:07:17ZengDove Medical PressInternational Journal of Nanomedicine1178-20132025-01-01Volume 201133114599698Injectable Self-Assembling Procyanidin Nanospheres for Effective Osteoarthritis TreatmentLi GHe FFeng JXu GWu CQiao YLiu YChen HDu PWang JGuangjie Li,1,2,* Fei He,2,* Jianbao Feng,3 Ge Xu,1 Chengye Wu,1 Yufei Qiao,1 Yang Liu,3 Hanlin Chen,1 Pengcheng Du,4 Jizeng Wang2 1The First Hospital of Lanzhou University, Lanzhou, Gansu Province, People’s Republic of China; 2College of Civil Engineering and Mechanics, Lanzhou University, Lanzhou, Gansu Province, People’s Republic of China; 3Hospital of Stomatology, Lanzhou University, Lanzhou, Gansu Province, People’s Republic of China; 4College of Chemistry and Chemical Engineering, Lanzhou University, Gansu Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jizeng Wang, Email jzwang@lzu.edu.cnBackground: Osteoarthritis (OA), a prevalent joint disease, causes immense suffering to thousands of patients, impairing their mobility and diminishing their quality of life. Current treatment methods primarily rely on analgesics or anti-inflammatory drugs to alleviate symptoms but fail to achieve the desired therapeutic outcome.Methods: To better realize therapeutic effects of OA, procyanidins (PAs), as a type of plant flavonoids with strong antioxidant and anti-inflammatory activities, were designed to self-assembly with well-dispersible Pluronic F127 (PF127) through the hydrogen-bond interaction to present an injectable, biocompatibility PA nanospheres.Results: These nanospheres significantly increased the cell viability in mouse L929 fibroblasts and ADTC5 chondrocytes compared with unassembled PAs. In addition, the self-assembling PAs/PF127 nanospheres enhanced the protein expression of collagen (COL1A1 and COL3A1) in fibroblasts, and the expression of glycosaminoglycan and COL2A1 was also higher than unassembled PAs in chondrocytes, this heralded the potential to achieve OA repair strategies at the cellular level. In an enzymolysis model of rat OA, PAs/PF127 nanospheres significantly reduce joint space swelling in the early stages of cartilage destruction and accelerate the formation of subchondral bone and cartilaginous surface.Implication: This study offers valuable insights into the preparation of novel PA nanospheres for effective repair of OA.Keywords: procyanidin, self-assembling nanospheres, injectable, osteoarthritis treatmenthttps://www.dovepress.com/injectable-self-assembling-procyanidin-nanospheres-for-effective-osteo-peer-reviewed-fulltext-article-IJNprocyanidinself-assembling nanospheresinjectableosteoarthritis treatment. |
| spellingShingle | Li G He F Feng J Xu G Wu C Qiao Y Liu Y Chen H Du P Wang J Injectable Self-Assembling Procyanidin Nanospheres for Effective Osteoarthritis Treatment International Journal of Nanomedicine procyanidin self-assembling nanospheres injectable osteoarthritis treatment. |
| title | Injectable Self-Assembling Procyanidin Nanospheres for Effective Osteoarthritis Treatment |
| title_full | Injectable Self-Assembling Procyanidin Nanospheres for Effective Osteoarthritis Treatment |
| title_fullStr | Injectable Self-Assembling Procyanidin Nanospheres for Effective Osteoarthritis Treatment |
| title_full_unstemmed | Injectable Self-Assembling Procyanidin Nanospheres for Effective Osteoarthritis Treatment |
| title_short | Injectable Self-Assembling Procyanidin Nanospheres for Effective Osteoarthritis Treatment |
| title_sort | injectable self assembling procyanidin nanospheres for effective osteoarthritis treatment |
| topic | procyanidin self-assembling nanospheres injectable osteoarthritis treatment. |
| url | https://www.dovepress.com/injectable-self-assembling-procyanidin-nanospheres-for-effective-osteo-peer-reviewed-fulltext-article-IJN |
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