Mandible-derived extracellular vesicles regulate early tooth development in miniature swine via targeting KDM2B
Abstract Tissue interactions play a crucial role in tooth development. Notably, extracellular vesicle-mediated interactions between the mandible and tooth germ are considered essential. Here, we revealed that mandible extracellular vesicles could modulate the proliferation and differentiation of den...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-04-01
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| Series: | International Journal of Oral Science |
| Online Access: | https://doi.org/10.1038/s41368-025-00348-w |
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| _version_ | 1849712830922620928 |
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| author | Ye Li Meng Sun Yi Ding Ang Li |
| author_facet | Ye Li Meng Sun Yi Ding Ang Li |
| author_sort | Ye Li |
| collection | DOAJ |
| description | Abstract Tissue interactions play a crucial role in tooth development. Notably, extracellular vesicle-mediated interactions between the mandible and tooth germ are considered essential. Here, we revealed that mandible extracellular vesicles could modulate the proliferation and differentiation of dental mesenchymal cells by regulating the histone demethylase KDM2B. Further investigation showed that mandible derived extracellular vesicles could deliver miR-206 to KDM2B, thereby regulating tooth development. An animal study demonstrated that the miR-206/KDM2B pathway affected tooth morphogenesis and mineralization after eight weeks of subcutaneous transplantation in nude mice. In conclusion, this study suggested that the mandible played a critical role in tooth morphogenesis and mineralization, which could be a potential therapeutic target for abnormal tooth development and an alternative model for tooth regeneration. |
| format | Article |
| id | doaj-art-7866f156b39f48a69314085b7f6c22fe |
| institution | DOAJ |
| issn | 2049-3169 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | International Journal of Oral Science |
| spelling | doaj-art-7866f156b39f48a69314085b7f6c22fe2025-08-20T03:14:09ZengNature Publishing GroupInternational Journal of Oral Science2049-31692025-04-0117111010.1038/s41368-025-00348-wMandible-derived extracellular vesicles regulate early tooth development in miniature swine via targeting KDM2BYe Li0Meng Sun1Yi Ding2Ang Li3Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong UniversityKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong UniversityKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong UniversityKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong UniversityAbstract Tissue interactions play a crucial role in tooth development. Notably, extracellular vesicle-mediated interactions between the mandible and tooth germ are considered essential. Here, we revealed that mandible extracellular vesicles could modulate the proliferation and differentiation of dental mesenchymal cells by regulating the histone demethylase KDM2B. Further investigation showed that mandible derived extracellular vesicles could deliver miR-206 to KDM2B, thereby regulating tooth development. An animal study demonstrated that the miR-206/KDM2B pathway affected tooth morphogenesis and mineralization after eight weeks of subcutaneous transplantation in nude mice. In conclusion, this study suggested that the mandible played a critical role in tooth morphogenesis and mineralization, which could be a potential therapeutic target for abnormal tooth development and an alternative model for tooth regeneration.https://doi.org/10.1038/s41368-025-00348-w |
| spellingShingle | Ye Li Meng Sun Yi Ding Ang Li Mandible-derived extracellular vesicles regulate early tooth development in miniature swine via targeting KDM2B International Journal of Oral Science |
| title | Mandible-derived extracellular vesicles regulate early tooth development in miniature swine via targeting KDM2B |
| title_full | Mandible-derived extracellular vesicles regulate early tooth development in miniature swine via targeting KDM2B |
| title_fullStr | Mandible-derived extracellular vesicles regulate early tooth development in miniature swine via targeting KDM2B |
| title_full_unstemmed | Mandible-derived extracellular vesicles regulate early tooth development in miniature swine via targeting KDM2B |
| title_short | Mandible-derived extracellular vesicles regulate early tooth development in miniature swine via targeting KDM2B |
| title_sort | mandible derived extracellular vesicles regulate early tooth development in miniature swine via targeting kdm2b |
| url | https://doi.org/10.1038/s41368-025-00348-w |
| work_keys_str_mv | AT yeli mandiblederivedextracellularvesiclesregulateearlytoothdevelopmentinminiatureswineviatargetingkdm2b AT mengsun mandiblederivedextracellularvesiclesregulateearlytoothdevelopmentinminiatureswineviatargetingkdm2b AT yiding mandiblederivedextracellularvesiclesregulateearlytoothdevelopmentinminiatureswineviatargetingkdm2b AT angli mandiblederivedextracellularvesiclesregulateearlytoothdevelopmentinminiatureswineviatargetingkdm2b |