Photodynamic therapy combined with palliative resection and secondary healing for periocular basal cell carcinoma with inadequate surgical margins
Periocular basal cell carcinoma (pBCC) is the most common malignancy in the periocular region, characterized by local aggressiveness, high incidence, and significant recurrence rates. While surgery is the primary treatment option, achieving complete lesion removal can be challenging due to the sensi...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100025000304 |
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| author | Xiaoqing Wang Ting Zhang Tianhang Li Yahui Feng Li Ma Dongmei Li Yeqiang Song Dongmei Shi |
| author_facet | Xiaoqing Wang Ting Zhang Tianhang Li Yahui Feng Li Ma Dongmei Li Yeqiang Song Dongmei Shi |
| author_sort | Xiaoqing Wang |
| collection | DOAJ |
| description | Periocular basal cell carcinoma (pBCC) is the most common malignancy in the periocular region, characterized by local aggressiveness, high incidence, and significant recurrence rates. While surgery is the primary treatment option, achieving complete lesion removal can be challenging due to the sensitive anatomy of this area and associated cosmetic considerations. Recent advancements in photodynamic therapy (PDT) have demonstrated promising efficacy and cosmetic outcomes for superficial BCC, offering alternatives to traditional treatments. However, PDT's effectiveness is often limited by the penetration depth of photosensitizers, particularly for deep tumors. To address these challenges, we developed a regimen that combines palliative surgery with immediate PDT for pBCC cases with inadequate or positive surgical margins. This integrated approach aims to overcome the penetration limitations of PDT while enhancing tumor clearance and preserving cosmetic outcomes. We report on three cases where all patients achieved complete clinical remission, with satisfactory cosmetic results and no recurrence observed during follow-up periods ranging from 12 to 23 months. Our findings suggest that palliative surgical resection, in conjunction with PDT, represents an effective treatment strategy for pBCC. This approach is particularly valuable when standard surgical margins cannot be achieved, especially considering the importance of cosmetic healing. |
| format | Article |
| id | doaj-art-78661b4a4cab4c28af4acac0995be8d6 |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-78661b4a4cab4c28af4acac0995be8d62025-02-05T04:31:22ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-04-0152104500Photodynamic therapy combined with palliative resection and secondary healing for periocular basal cell carcinoma with inadequate surgical marginsXiaoqing Wang0Ting Zhang1Tianhang Li2Yahui Feng3Li Ma4Dongmei Li5Yeqiang Song6Dongmei Shi7Department of Dermatology, Jining No. 1 People's Hospital, PR China; First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, PR ChinaDepartment of Dermatology, Jining No. 1 People's Hospital, PR ChinaDepartment of Dermatology, Jining No. 1 People's Hospital, PR ChinaLaboratory of Medical Mycology, Jining No. 1 People's Hospital, Shandong, PR ChinaLaboratory of Medical Mycology, Jining No. 1 People's Hospital, Shandong, PR ChinaDepartment of Microbiology & Immunology, Georgetown University Medical Center, Washington, DC, 20057, USADepartment of Cosmetic Dermatology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong, PR China; Affiliated Hospital of Shandong University of Traditional Chinese Medicine, No. 16369, Jingshi Road, Jinan City, Shandong Province, PR China.Department of Dermatology, Jining No. 1 People's Hospital, PR China; Laboratory of Medical Mycology, Jining No. 1 People's Hospital, Shandong, PR China; Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, DC, 20057, USA; Corresponding authors at Department of Dermatology, Jining No. 1 People's Hospital, No. 6 Jiankang Road, Jining, 272000, Shandong Province, PR China.Periocular basal cell carcinoma (pBCC) is the most common malignancy in the periocular region, characterized by local aggressiveness, high incidence, and significant recurrence rates. While surgery is the primary treatment option, achieving complete lesion removal can be challenging due to the sensitive anatomy of this area and associated cosmetic considerations. Recent advancements in photodynamic therapy (PDT) have demonstrated promising efficacy and cosmetic outcomes for superficial BCC, offering alternatives to traditional treatments. However, PDT's effectiveness is often limited by the penetration depth of photosensitizers, particularly for deep tumors. To address these challenges, we developed a regimen that combines palliative surgery with immediate PDT for pBCC cases with inadequate or positive surgical margins. This integrated approach aims to overcome the penetration limitations of PDT while enhancing tumor clearance and preserving cosmetic outcomes. We report on three cases where all patients achieved complete clinical remission, with satisfactory cosmetic results and no recurrence observed during follow-up periods ranging from 12 to 23 months. Our findings suggest that palliative surgical resection, in conjunction with PDT, represents an effective treatment strategy for pBCC. This approach is particularly valuable when standard surgical margins cannot be achieved, especially considering the importance of cosmetic healing.http://www.sciencedirect.com/science/article/pii/S1572100025000304Periocular basal cell carcinomaPalliative resection;secondary healing, photodynamic therapy |
| spellingShingle | Xiaoqing Wang Ting Zhang Tianhang Li Yahui Feng Li Ma Dongmei Li Yeqiang Song Dongmei Shi Photodynamic therapy combined with palliative resection and secondary healing for periocular basal cell carcinoma with inadequate surgical margins Photodiagnosis and Photodynamic Therapy Periocular basal cell carcinoma Palliative resection;secondary healing, photodynamic therapy |
| title | Photodynamic therapy combined with palliative resection and secondary healing for periocular basal cell carcinoma with inadequate surgical margins |
| title_full | Photodynamic therapy combined with palliative resection and secondary healing for periocular basal cell carcinoma with inadequate surgical margins |
| title_fullStr | Photodynamic therapy combined with palliative resection and secondary healing for periocular basal cell carcinoma with inadequate surgical margins |
| title_full_unstemmed | Photodynamic therapy combined with palliative resection and secondary healing for periocular basal cell carcinoma with inadequate surgical margins |
| title_short | Photodynamic therapy combined with palliative resection and secondary healing for periocular basal cell carcinoma with inadequate surgical margins |
| title_sort | photodynamic therapy combined with palliative resection and secondary healing for periocular basal cell carcinoma with inadequate surgical margins |
| topic | Periocular basal cell carcinoma Palliative resection;secondary healing, photodynamic therapy |
| url | http://www.sciencedirect.com/science/article/pii/S1572100025000304 |
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