VEGFA, MYC, and JUN are abnormally elevated in the synovial tissue of patients with advanced osteoarthritis
Abstract Osteoarthritis (OA), affecting > 500 million people worldwide, profoundly affects the quality of life and ability to work. The mitogen-activated protein kinase (MAPK) signaling pathway plays an essential role in OA. To address the lack of studies focused on synovial cells in OA, we evalu...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-80551-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594771982417920 |
|---|---|
| author | Genxiang Rong Zhenyu Zhang Wenjing Zhan Minnan Chen Jingjing Ruan Cailiang Shen |
| author_facet | Genxiang Rong Zhenyu Zhang Wenjing Zhan Minnan Chen Jingjing Ruan Cailiang Shen |
| author_sort | Genxiang Rong |
| collection | DOAJ |
| description | Abstract Osteoarthritis (OA), affecting > 500 million people worldwide, profoundly affects the quality of life and ability to work. The mitogen-activated protein kinase (MAPK) signaling pathway plays an essential role in OA. To address the lack of studies focused on synovial cells in OA, we evaluated the expression patterns and roles of the MAPK signaling pathway components in OA synovial tissues using bioinformatics. The JUN, MYC, and VEGFA expression levels were significantly higher in the synovial tissues of patients with OA than in control tissues. These loci were closely related to abnormal proliferation, inflammation, and angiogenesis in the synovial tissues of patients with OA. We speculate that Myc and VEGFA activate the p38-MAPK signaling pathway to further activate Jun, thereby promoting abnormal inflammation, proliferation, and angiogenesis in OA synovial tissue. The high MYC, JUN, and VEGFA expression was positively correlated with the patients’ K-L score, pain time, and synovial score. Furthermore, the high p38-MAPK and P-p38-MAPK expression confirmed that the abnormal expression and activation of the MAPK signaling pathway occurred in the synovial tissue of patients with OA. Our findings may provide a new direction for the clinical diagnosis and treatment of OA and insights into its pathogenesis. |
| format | Article |
| id | doaj-art-78603e79f707488ca2bf5e104f9ab34b |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-78603e79f707488ca2bf5e104f9ab34b2025-01-19T12:21:41ZengNature PortfolioScientific Reports2045-23222025-01-0115111710.1038/s41598-024-80551-7VEGFA, MYC, and JUN are abnormally elevated in the synovial tissue of patients with advanced osteoarthritisGenxiang Rong0Zhenyu Zhang1Wenjing Zhan2Minnan Chen3Jingjing Ruan4Cailiang Shen5Department of Orthopedics, The First Affiliated Hospital of Anhui Medical UniversityInstitute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan UniversityAnhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical UniversityAnhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical UniversityDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical UniversityDepartment of Orthopedics, The First Affiliated Hospital of Anhui Medical UniversityAbstract Osteoarthritis (OA), affecting > 500 million people worldwide, profoundly affects the quality of life and ability to work. The mitogen-activated protein kinase (MAPK) signaling pathway plays an essential role in OA. To address the lack of studies focused on synovial cells in OA, we evaluated the expression patterns and roles of the MAPK signaling pathway components in OA synovial tissues using bioinformatics. The JUN, MYC, and VEGFA expression levels were significantly higher in the synovial tissues of patients with OA than in control tissues. These loci were closely related to abnormal proliferation, inflammation, and angiogenesis in the synovial tissues of patients with OA. We speculate that Myc and VEGFA activate the p38-MAPK signaling pathway to further activate Jun, thereby promoting abnormal inflammation, proliferation, and angiogenesis in OA synovial tissue. The high MYC, JUN, and VEGFA expression was positively correlated with the patients’ K-L score, pain time, and synovial score. Furthermore, the high p38-MAPK and P-p38-MAPK expression confirmed that the abnormal expression and activation of the MAPK signaling pathway occurred in the synovial tissue of patients with OA. Our findings may provide a new direction for the clinical diagnosis and treatment of OA and insights into its pathogenesis.https://doi.org/10.1038/s41598-024-80551-7OsteoarthritisMAPKMYCVEGFAJUNSynovial tissue |
| spellingShingle | Genxiang Rong Zhenyu Zhang Wenjing Zhan Minnan Chen Jingjing Ruan Cailiang Shen VEGFA, MYC, and JUN are abnormally elevated in the synovial tissue of patients with advanced osteoarthritis Scientific Reports Osteoarthritis MAPK MYC VEGFA JUN Synovial tissue |
| title | VEGFA, MYC, and JUN are abnormally elevated in the synovial tissue of patients with advanced osteoarthritis |
| title_full | VEGFA, MYC, and JUN are abnormally elevated in the synovial tissue of patients with advanced osteoarthritis |
| title_fullStr | VEGFA, MYC, and JUN are abnormally elevated in the synovial tissue of patients with advanced osteoarthritis |
| title_full_unstemmed | VEGFA, MYC, and JUN are abnormally elevated in the synovial tissue of patients with advanced osteoarthritis |
| title_short | VEGFA, MYC, and JUN are abnormally elevated in the synovial tissue of patients with advanced osteoarthritis |
| title_sort | vegfa myc and jun are abnormally elevated in the synovial tissue of patients with advanced osteoarthritis |
| topic | Osteoarthritis MAPK MYC VEGFA JUN Synovial tissue |
| url | https://doi.org/10.1038/s41598-024-80551-7 |
| work_keys_str_mv | AT genxiangrong vegfamycandjunareabnormallyelevatedinthesynovialtissueofpatientswithadvancedosteoarthritis AT zhenyuzhang vegfamycandjunareabnormallyelevatedinthesynovialtissueofpatientswithadvancedosteoarthritis AT wenjingzhan vegfamycandjunareabnormallyelevatedinthesynovialtissueofpatientswithadvancedosteoarthritis AT minnanchen vegfamycandjunareabnormallyelevatedinthesynovialtissueofpatientswithadvancedosteoarthritis AT jingjingruan vegfamycandjunareabnormallyelevatedinthesynovialtissueofpatientswithadvancedosteoarthritis AT cailiangshen vegfamycandjunareabnormallyelevatedinthesynovialtissueofpatientswithadvancedosteoarthritis |