Neurotropic Melanoma: The Management of Localised Disease
Neurotropic melanoma is a rare subtype of cutaneous malignant melanoma. Compared with conventional melanoma, it is more locally aggressive with an increased tendency for local recurrence but less likely for nodal or distant metastases. These tumours can be a diagnostic dilemma with a variety of morp...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Journal of Skin Cancer |
| Online Access: | http://dx.doi.org/10.1155/2012/706452 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554093397147648 |
|---|---|
| author | Jeremy Croker Bryan Burmeister Matthew Foote |
| author_facet | Jeremy Croker Bryan Burmeister Matthew Foote |
| author_sort | Jeremy Croker |
| collection | DOAJ |
| description | Neurotropic melanoma is a rare subtype of cutaneous malignant melanoma. Compared with conventional melanoma, it is more locally aggressive with an increased tendency for local recurrence but less likely for nodal or distant metastases. These tumours can be a diagnostic dilemma with a variety of morphological, histopathological, and immunophenotypical expressions. The often amelanotic, benign appearance may lead to treatment issues such as late presentation, diagnostic delay, misdiagnosis, insufficient surgical margins, and recurrence with resulting poor outcome. The neurotropic nature of the disease and prevalence in the head and neck region can result in perineural and neural invasion along named large nerves into the brain with resulting neuropathies. Wide local excision with adjuvant radiotherapy where indicated remains the current practice for treatment with chemotherapy predominately being reserved as a salvage treatment for patients with disseminated disease. |
| format | Article |
| id | doaj-art-7855b0d6d41c4122b27a82cd5be4cb50 |
| institution | Kabale University |
| issn | 2090-2905 2090-2913 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Skin Cancer |
| spelling | doaj-art-7855b0d6d41c4122b27a82cd5be4cb502025-02-03T05:52:19ZengWileyJournal of Skin Cancer2090-29052090-29132012-01-01201210.1155/2012/706452706452Neurotropic Melanoma: The Management of Localised DiseaseJeremy Croker0Bryan Burmeister1Matthew Foote2Radiation Oncology Queensland, Liz Plummer Cancer Center, Lake and Grove Streets, Cairns, QLD 4870, AustraliaDivision of Cancer Services, Princess Alexandra Hospital, University of Queensland, 199 Ipswich Road Woolloongabba, QLD 4102, AustraliaDivision of Cancer Services, Princess Alexandra Hospital, University of Queensland, 199 Ipswich Road Woolloongabba, QLD 4102, AustraliaNeurotropic melanoma is a rare subtype of cutaneous malignant melanoma. Compared with conventional melanoma, it is more locally aggressive with an increased tendency for local recurrence but less likely for nodal or distant metastases. These tumours can be a diagnostic dilemma with a variety of morphological, histopathological, and immunophenotypical expressions. The often amelanotic, benign appearance may lead to treatment issues such as late presentation, diagnostic delay, misdiagnosis, insufficient surgical margins, and recurrence with resulting poor outcome. The neurotropic nature of the disease and prevalence in the head and neck region can result in perineural and neural invasion along named large nerves into the brain with resulting neuropathies. Wide local excision with adjuvant radiotherapy where indicated remains the current practice for treatment with chemotherapy predominately being reserved as a salvage treatment for patients with disseminated disease.http://dx.doi.org/10.1155/2012/706452 |
| spellingShingle | Jeremy Croker Bryan Burmeister Matthew Foote Neurotropic Melanoma: The Management of Localised Disease Journal of Skin Cancer |
| title | Neurotropic Melanoma: The Management of Localised Disease |
| title_full | Neurotropic Melanoma: The Management of Localised Disease |
| title_fullStr | Neurotropic Melanoma: The Management of Localised Disease |
| title_full_unstemmed | Neurotropic Melanoma: The Management of Localised Disease |
| title_short | Neurotropic Melanoma: The Management of Localised Disease |
| title_sort | neurotropic melanoma the management of localised disease |
| url | http://dx.doi.org/10.1155/2012/706452 |
| work_keys_str_mv | AT jeremycroker neurotropicmelanomathemanagementoflocaliseddisease AT bryanburmeister neurotropicmelanomathemanagementoflocaliseddisease AT matthewfoote neurotropicmelanomathemanagementoflocaliseddisease |