Male Child with Van Wyk-Grumbach's Syndrome and Other Complications of Long-Standing Primary Hypothyroidism: A Case Report

Primary hypothyroidism in the juvenile population generally leads to retardation of linear growth and delay or even arrest of puberty. However, in rare conditions, children with long-standing hypothyroidism present with signs of Van Wyk-Grumbach's syndrome (VWGS) which include juvenile hypothyr...

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Main Authors: Ahmed Omran, Jing Peng, Biswas Shrestha, Muhammad Usman Ashhab, Fei Yin
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Case Reports in Pediatrics
Online Access:http://dx.doi.org/10.1155/2012/352751
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author Ahmed Omran
Jing Peng
Biswas Shrestha
Muhammad Usman Ashhab
Fei Yin
author_facet Ahmed Omran
Jing Peng
Biswas Shrestha
Muhammad Usman Ashhab
Fei Yin
author_sort Ahmed Omran
collection DOAJ
description Primary hypothyroidism in the juvenile population generally leads to retardation of linear growth and delay or even arrest of puberty. However, in rare conditions, children with long-standing hypothyroidism present with signs of Van Wyk-Grumbach's syndrome (VWGS) which include juvenile hypothyroidism, delayed bone age, and pseudoprecocious puberty. We report a rare case of prepubertal male child from Asian origin, presented with long-standing untreated hypothyroidism complicated with VWGS and other complications including obesity, short stature, hepatomegaly, asymptomatic mild pericardial effusion, and pituitary hyperplasia.
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institution Kabale University
issn 2090-6803
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language English
publishDate 2012-01-01
publisher Wiley
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series Case Reports in Pediatrics
spelling doaj-art-7855658d511f4138be3dbd865006b69e2025-02-03T06:06:47ZengWileyCase Reports in Pediatrics2090-68032090-68112012-01-01201210.1155/2012/352751352751Male Child with Van Wyk-Grumbach's Syndrome and Other Complications of Long-Standing Primary Hypothyroidism: A Case ReportAhmed Omran0Jing Peng1Biswas Shrestha2Muhammad Usman Ashhab3Fei Yin4Department of Pediatrics, Xiangya Hospital of Central South University, No. 87 Xiangya Road, Changsha, Hunan 410008, ChinaDepartment of Pediatrics, Xiangya Hospital of Central South University, No. 87 Xiangya Road, Changsha, Hunan 410008, ChinaDepartment of Radiology, Third Xiangya Hospital of Central South University, Changsha, Hunan 410008, ChinaDepartment of Pediatrics, Xiangya Hospital of Central South University, No. 87 Xiangya Road, Changsha, Hunan 410008, ChinaDepartment of Pediatrics, Xiangya Hospital of Central South University, No. 87 Xiangya Road, Changsha, Hunan 410008, ChinaPrimary hypothyroidism in the juvenile population generally leads to retardation of linear growth and delay or even arrest of puberty. However, in rare conditions, children with long-standing hypothyroidism present with signs of Van Wyk-Grumbach's syndrome (VWGS) which include juvenile hypothyroidism, delayed bone age, and pseudoprecocious puberty. We report a rare case of prepubertal male child from Asian origin, presented with long-standing untreated hypothyroidism complicated with VWGS and other complications including obesity, short stature, hepatomegaly, asymptomatic mild pericardial effusion, and pituitary hyperplasia.http://dx.doi.org/10.1155/2012/352751
spellingShingle Ahmed Omran
Jing Peng
Biswas Shrestha
Muhammad Usman Ashhab
Fei Yin
Male Child with Van Wyk-Grumbach's Syndrome and Other Complications of Long-Standing Primary Hypothyroidism: A Case Report
Case Reports in Pediatrics
title Male Child with Van Wyk-Grumbach's Syndrome and Other Complications of Long-Standing Primary Hypothyroidism: A Case Report
title_full Male Child with Van Wyk-Grumbach's Syndrome and Other Complications of Long-Standing Primary Hypothyroidism: A Case Report
title_fullStr Male Child with Van Wyk-Grumbach's Syndrome and Other Complications of Long-Standing Primary Hypothyroidism: A Case Report
title_full_unstemmed Male Child with Van Wyk-Grumbach's Syndrome and Other Complications of Long-Standing Primary Hypothyroidism: A Case Report
title_short Male Child with Van Wyk-Grumbach's Syndrome and Other Complications of Long-Standing Primary Hypothyroidism: A Case Report
title_sort male child with van wyk grumbach s syndrome and other complications of long standing primary hypothyroidism a case report
url http://dx.doi.org/10.1155/2012/352751
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AT biswasshrestha malechildwithvanwykgrumbachssyndromeandothercomplicationsoflongstandingprimaryhypothyroidismacasereport
AT muhammadusmanashhab malechildwithvanwykgrumbachssyndromeandothercomplicationsoflongstandingprimaryhypothyroidismacasereport
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