PPARgamma-Dependent Control of Renin Expression: Molecular Mechanisms and Pathophysiological Relevance
During the last years accumulating evidence demonstrated that the nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) regulates the expression of renin gene and thus the overall renin production. This review summarizes the current knowledge of the transcriptional control of...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2013/451016 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562412276940800 |
|---|---|
| author | Vladimir T. Todorov |
| author_facet | Vladimir T. Todorov |
| author_sort | Vladimir T. Todorov |
| collection | DOAJ |
| description | During the last years accumulating evidence demonstrated that the nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) regulates the expression of renin gene and thus the overall renin production. This review summarizes the current knowledge of the transcriptional control of the renin gene by PPARgamma received from variety of models ranging from cell culture to transgenic animals. The molecular mechanisms of the PPARgamma action on renin are particularly interesting because they are featured by two newly described characteristics: one of them is the recently identified PPARgamma target sequence Pal3 which is specific for the human renin gene and mediates exceptionally high sensitivity to transactivation; the other is the potentiating effect of PPARgamma on the cAMP signaling in the renin-producing cells. Furthermore, I discuss the need for generating of additional transgenic animal models which are more appropriate with regard to the role of the PPARgamma-dependent regulation of the renin gene expression in human diseases such as arterial hypertension and metabolic syndrome. |
| format | Article |
| id | doaj-art-7843407c40d249e1acab3920c20540bc |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-7843407c40d249e1acab3920c20540bc2025-02-03T01:22:39ZengWileyPPAR Research1687-47571687-47652013-01-01201310.1155/2013/451016451016PPARgamma-Dependent Control of Renin Expression: Molecular Mechanisms and Pathophysiological RelevanceVladimir T. Todorov0Experimental Nephrology, Division of Nephrology, Department of Medicine III, University Hospital Carl Gustav Carus, TU Dresden, 01307 Dresden, GermanyDuring the last years accumulating evidence demonstrated that the nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) regulates the expression of renin gene and thus the overall renin production. This review summarizes the current knowledge of the transcriptional control of the renin gene by PPARgamma received from variety of models ranging from cell culture to transgenic animals. The molecular mechanisms of the PPARgamma action on renin are particularly interesting because they are featured by two newly described characteristics: one of them is the recently identified PPARgamma target sequence Pal3 which is specific for the human renin gene and mediates exceptionally high sensitivity to transactivation; the other is the potentiating effect of PPARgamma on the cAMP signaling in the renin-producing cells. Furthermore, I discuss the need for generating of additional transgenic animal models which are more appropriate with regard to the role of the PPARgamma-dependent regulation of the renin gene expression in human diseases such as arterial hypertension and metabolic syndrome.http://dx.doi.org/10.1155/2013/451016 |
| spellingShingle | Vladimir T. Todorov PPARgamma-Dependent Control of Renin Expression: Molecular Mechanisms and Pathophysiological Relevance PPAR Research |
| title | PPARgamma-Dependent Control of Renin Expression: Molecular Mechanisms and Pathophysiological Relevance |
| title_full | PPARgamma-Dependent Control of Renin Expression: Molecular Mechanisms and Pathophysiological Relevance |
| title_fullStr | PPARgamma-Dependent Control of Renin Expression: Molecular Mechanisms and Pathophysiological Relevance |
| title_full_unstemmed | PPARgamma-Dependent Control of Renin Expression: Molecular Mechanisms and Pathophysiological Relevance |
| title_short | PPARgamma-Dependent Control of Renin Expression: Molecular Mechanisms and Pathophysiological Relevance |
| title_sort | ppargamma dependent control of renin expression molecular mechanisms and pathophysiological relevance |
| url | http://dx.doi.org/10.1155/2013/451016 |
| work_keys_str_mv | AT vladimirttodorov ppargammadependentcontrolofreninexpressionmolecularmechanismsandpathophysiologicalrelevance |