TLR2 and TLR4 in the Brain Injury Caused by Cerebral Ischemia and Reperfusion
Brain injury caused by cerebral ischemia/reperfusion is a complicated pathophysiological course, in which inflammation is thought to play an important role. Toll-like receptors are a type of transmembrane proteins, which can recognize either exogenous pathogen-associated molecular patterns or endoge...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/124614 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832546604507201536 |
|---|---|
| author | Ying Wang Pengfei Ge Yuhong Zhu |
| author_facet | Ying Wang Pengfei Ge Yuhong Zhu |
| author_sort | Ying Wang |
| collection | DOAJ |
| description | Brain injury caused by cerebral ischemia/reperfusion is a complicated pathophysiological course, in which inflammation is thought to play an important role. Toll-like receptors are a type of transmembrane proteins, which can recognize either exogenous pathogen-associated molecular patterns or endogenous stress or damage-associated molecular patterns in the innate immune system and initiate inflammatory responses. Among Toll-like receptors, TLR2 and TLR4 are found to be more important than others in the pathological progression of cerebral injury due to ischemia and reperfusion. This review will focus on the biological characteristics and functions of TLR2 and TLR4 and their downstream signal pathways. |
| format | Article |
| id | doaj-art-783e36e19b674f5a8ff7460b88175567 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-783e36e19b674f5a8ff7460b881755672025-02-03T06:47:54ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/124614124614TLR2 and TLR4 in the Brain Injury Caused by Cerebral Ischemia and ReperfusionYing Wang0Pengfei Ge1Yuhong Zhu2Department of Neurology, Second Affiliated Hospital of Kunming Medical University, Kunming 650031, ChinaDepartment of Neurosurgery, First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Neurology, Second Affiliated Hospital of Kunming Medical University, Kunming 650031, ChinaBrain injury caused by cerebral ischemia/reperfusion is a complicated pathophysiological course, in which inflammation is thought to play an important role. Toll-like receptors are a type of transmembrane proteins, which can recognize either exogenous pathogen-associated molecular patterns or endogenous stress or damage-associated molecular patterns in the innate immune system and initiate inflammatory responses. Among Toll-like receptors, TLR2 and TLR4 are found to be more important than others in the pathological progression of cerebral injury due to ischemia and reperfusion. This review will focus on the biological characteristics and functions of TLR2 and TLR4 and their downstream signal pathways.http://dx.doi.org/10.1155/2013/124614 |
| spellingShingle | Ying Wang Pengfei Ge Yuhong Zhu TLR2 and TLR4 in the Brain Injury Caused by Cerebral Ischemia and Reperfusion Mediators of Inflammation |
| title | TLR2 and TLR4 in the Brain Injury Caused by Cerebral Ischemia and Reperfusion |
| title_full | TLR2 and TLR4 in the Brain Injury Caused by Cerebral Ischemia and Reperfusion |
| title_fullStr | TLR2 and TLR4 in the Brain Injury Caused by Cerebral Ischemia and Reperfusion |
| title_full_unstemmed | TLR2 and TLR4 in the Brain Injury Caused by Cerebral Ischemia and Reperfusion |
| title_short | TLR2 and TLR4 in the Brain Injury Caused by Cerebral Ischemia and Reperfusion |
| title_sort | tlr2 and tlr4 in the brain injury caused by cerebral ischemia and reperfusion |
| url | http://dx.doi.org/10.1155/2013/124614 |
| work_keys_str_mv | AT yingwang tlr2andtlr4inthebraininjurycausedbycerebralischemiaandreperfusion AT pengfeige tlr2andtlr4inthebraininjurycausedbycerebralischemiaandreperfusion AT yuhongzhu tlr2andtlr4inthebraininjurycausedbycerebralischemiaandreperfusion |