Circulating Levels of Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Schizophrenia: a systematic review and meta-analysis
Abstract Background Glial cell line-derived neurotrophic factor (GDNF) has emerged as a potential biomarker for schizophrenia (SCZ). However, GDNF levels remain unclear in affected individuals compared to healthy controls. Therefore, we aimed to calculate a pooled estimate of GDNF levels in patients...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12888-025-06498-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571453422174208 |
|---|---|
| author | Omran Davarinejad Saeid Komasi Mohammad-Taher Moradi Farzaneh Golmohammadi Maryam Bahrami Hamed Esmaeil Lashgarian Masumeh Jalalvand Sara Hookari Fatemeh Kazemisafa |
| author_facet | Omran Davarinejad Saeid Komasi Mohammad-Taher Moradi Farzaneh Golmohammadi Maryam Bahrami Hamed Esmaeil Lashgarian Masumeh Jalalvand Sara Hookari Fatemeh Kazemisafa |
| author_sort | Omran Davarinejad |
| collection | DOAJ |
| description | Abstract Background Glial cell line-derived neurotrophic factor (GDNF) has emerged as a potential biomarker for schizophrenia (SCZ). However, GDNF levels remain unclear in affected individuals compared to healthy controls. Therefore, we aimed to calculate a pooled estimate of GDNF levels in patients with SCZ in comparison with healthy controls. Methods A systematic search was performed in PubMed, Scopus, Web of Science, and Science Direct for published studies from the first date available up to 17 June 2024. Twelve studies (n = 817 patients and 691 healthy controls) were included in the meta-analysis. Subgroup analyses and meta-regression were performed, addressing heterogeneity and publication bias. Results Random-effects estimates (d = –0.80, p < 0.001) of the present meta-analysis revealed a significant mean difference in GDNF levels between SCZ patients and healthy controls. Subgroup analyses indicated that the standardized mean difference of GDNF was larger in European samples (d = –1.01, p ≤ 0.001) than in the Asian population (d = –0.61, p = 0.011). Non-medicated SCZ patients (d = –1.08, p ≤ 0.001) exhibited lower GDNF levels than those on medication (d = – 0.70, p = 0.004). Additionally, patients with a disease duration of ≥ 10 years showed lower levels of GDNF (d = –0.93, p = 0.058 versus d = –0.82, p = 0.002). Conclusions The findings suggested that GDNF may be a promising biomarker and therapeutic target for schizophrenia. Future research should focus on elucidating the mechanisms underlying altered GDNF levels and exploring its implications for treatment strategies. |
| format | Article |
| id | doaj-art-78398546c073451f9a541ce2555025df |
| institution | Kabale University |
| issn | 1471-244X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj-art-78398546c073451f9a541ce2555025df2025-02-02T12:36:03ZengBMCBMC Psychiatry1471-244X2025-01-0125111010.1186/s12888-025-06498-9Circulating Levels of Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Schizophrenia: a systematic review and meta-analysisOmran Davarinejad0Saeid Komasi1Mohammad-Taher Moradi2Farzaneh Golmohammadi3Maryam Bahrami4Hamed Esmaeil Lashgarian5Masumeh Jalalvand6Sara Hookari7Fatemeh Kazemisafa8Clinical Research Development Center, Imam Khomeini and Mohammad Kermanshahi and Farabi Hospitals, Kermanshah University of Medical SciencesDepartment of Neuroscience and Psychopathology Research, Mind GPS InstituteSleep Disorders Research Center, Health Policy and Promotion Institute, Kermanshah University of Medical SciencesClinical Research Development Center, Imam Khomeini and Mohammad Kermanshahi and Farabi Hospitals, Kermanshah University of Medical SciencesClinical Research Development Center, Imam Khomeini and Mohammad Kermanshahi and Farabi Hospitals, Kermanshah University of Medical SciencesDepartment of Medical Biotechnology, Faculty of Medicine, Lorestan University of Medical SciencesDepartment of Medical Biotechnology, Faculty of Medicine, Lorestan University of Medical SciencesClinical Research Development Center, Imam Khomeini and Mohammad Kermanshahi and Farabi Hospitals, Kermanshah University of Medical SciencesClinical Research Development Center, Imam Khomeini and Mohammad Kermanshahi and Farabi Hospitals, Kermanshah University of Medical SciencesAbstract Background Glial cell line-derived neurotrophic factor (GDNF) has emerged as a potential biomarker for schizophrenia (SCZ). However, GDNF levels remain unclear in affected individuals compared to healthy controls. Therefore, we aimed to calculate a pooled estimate of GDNF levels in patients with SCZ in comparison with healthy controls. Methods A systematic search was performed in PubMed, Scopus, Web of Science, and Science Direct for published studies from the first date available up to 17 June 2024. Twelve studies (n = 817 patients and 691 healthy controls) were included in the meta-analysis. Subgroup analyses and meta-regression were performed, addressing heterogeneity and publication bias. Results Random-effects estimates (d = –0.80, p < 0.001) of the present meta-analysis revealed a significant mean difference in GDNF levels between SCZ patients and healthy controls. Subgroup analyses indicated that the standardized mean difference of GDNF was larger in European samples (d = –1.01, p ≤ 0.001) than in the Asian population (d = –0.61, p = 0.011). Non-medicated SCZ patients (d = –1.08, p ≤ 0.001) exhibited lower GDNF levels than those on medication (d = – 0.70, p = 0.004). Additionally, patients with a disease duration of ≥ 10 years showed lower levels of GDNF (d = –0.93, p = 0.058 versus d = –0.82, p = 0.002). Conclusions The findings suggested that GDNF may be a promising biomarker and therapeutic target for schizophrenia. Future research should focus on elucidating the mechanisms underlying altered GDNF levels and exploring its implications for treatment strategies.https://doi.org/10.1186/s12888-025-06498-9Glial cell line-derived neurotrophic factorGDNFMeta-analysisSchizophrenia |
| spellingShingle | Omran Davarinejad Saeid Komasi Mohammad-Taher Moradi Farzaneh Golmohammadi Maryam Bahrami Hamed Esmaeil Lashgarian Masumeh Jalalvand Sara Hookari Fatemeh Kazemisafa Circulating Levels of Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Schizophrenia: a systematic review and meta-analysis BMC Psychiatry Glial cell line-derived neurotrophic factor GDNF Meta-analysis Schizophrenia |
| title | Circulating Levels of Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Schizophrenia: a systematic review and meta-analysis |
| title_full | Circulating Levels of Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Schizophrenia: a systematic review and meta-analysis |
| title_fullStr | Circulating Levels of Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Schizophrenia: a systematic review and meta-analysis |
| title_full_unstemmed | Circulating Levels of Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Schizophrenia: a systematic review and meta-analysis |
| title_short | Circulating Levels of Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Schizophrenia: a systematic review and meta-analysis |
| title_sort | circulating levels of glial cell line derived neurotrophic factor gdnf in schizophrenia a systematic review and meta analysis |
| topic | Glial cell line-derived neurotrophic factor GDNF Meta-analysis Schizophrenia |
| url | https://doi.org/10.1186/s12888-025-06498-9 |
| work_keys_str_mv | AT omrandavarinejad circulatinglevelsofglialcelllinederivedneurotrophicfactorgdnfinschizophreniaasystematicreviewandmetaanalysis AT saeidkomasi circulatinglevelsofglialcelllinederivedneurotrophicfactorgdnfinschizophreniaasystematicreviewandmetaanalysis AT mohammadtahermoradi circulatinglevelsofglialcelllinederivedneurotrophicfactorgdnfinschizophreniaasystematicreviewandmetaanalysis AT farzanehgolmohammadi circulatinglevelsofglialcelllinederivedneurotrophicfactorgdnfinschizophreniaasystematicreviewandmetaanalysis AT maryambahrami circulatinglevelsofglialcelllinederivedneurotrophicfactorgdnfinschizophreniaasystematicreviewandmetaanalysis AT hamedesmaeillashgarian circulatinglevelsofglialcelllinederivedneurotrophicfactorgdnfinschizophreniaasystematicreviewandmetaanalysis AT masumehjalalvand circulatinglevelsofglialcelllinederivedneurotrophicfactorgdnfinschizophreniaasystematicreviewandmetaanalysis AT sarahookari circulatinglevelsofglialcelllinederivedneurotrophicfactorgdnfinschizophreniaasystematicreviewandmetaanalysis AT fatemehkazemisafa circulatinglevelsofglialcelllinederivedneurotrophicfactorgdnfinschizophreniaasystematicreviewandmetaanalysis |