Cancer Detection Rates of Systematic and Targeted Prostate Biopsies after Biparametric MRI
Objective. To compare prostate cancer detection rates (CDRs) and pathology results with targeted prostate biopsy (TB) and systematic prostate biopsy (SB) in biopsy-naive men. Methods. An in-patient control study of 82 men undergoing SB and subsequent TB in case of positive prostate MRI between 2015...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2020/4626781 |
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| author | Maudy C. W. Gayet Anouk A. M. A. van der Aa Harrie P. Beerlage Bart Ph Schrier Maaike Gielens Roel Heesakkers Gerrit J. Jager Peter F. A. Mulders Hessel Wijkstra |
| author_facet | Maudy C. W. Gayet Anouk A. M. A. van der Aa Harrie P. Beerlage Bart Ph Schrier Maaike Gielens Roel Heesakkers Gerrit J. Jager Peter F. A. Mulders Hessel Wijkstra |
| author_sort | Maudy C. W. Gayet |
| collection | DOAJ |
| description | Objective. To compare prostate cancer detection rates (CDRs) and pathology results with targeted prostate biopsy (TB) and systematic prostate biopsy (SB) in biopsy-naive men. Methods. An in-patient control study of 82 men undergoing SB and subsequent TB in case of positive prostate MRI between 2015 and 2017 in the Jeroen Bosch Hospital, the Netherlands. Results. Prostate cancer (PCa) was detected in 54.9% with 70.7% agreement between TB and SB. Significant PCa (Gleason score ≥7) was detected in 24.4%. The CDR with TB and SB was 35.4% and 48.8%, respectively (p=0.052). The CDR of significant prostate cancer with TB and SB was both 20.7%. Clinically significant pathology upgrading occurred in 7.3% by adding TB to SB and 22.0% by adding SB to TB. Conclusions. There is no statistically significant difference between CDRs of SB and TB. Both SB and TB miss significant PCas. Moreover, pathology upgrading occurred more often by adding SB to TB than vice versa. This indicates that the omission of SB in this study population might not be justified. |
| format | Article |
| id | doaj-art-78284e166bc54b9da16d3cc24506bfff |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-78284e166bc54b9da16d3cc24506bfff2025-02-03T01:04:05ZengWileyProstate Cancer2090-31112090-312X2020-01-01202010.1155/2020/46267814626781Cancer Detection Rates of Systematic and Targeted Prostate Biopsies after Biparametric MRIMaudy C. W. Gayet0Anouk A. M. A. van der Aa1Harrie P. Beerlage2Bart Ph Schrier3Maaike Gielens4Roel Heesakkers5Gerrit J. Jager6Peter F. A. Mulders7Hessel Wijkstra8Department of Urology, Jeroen Bosch Hospital, Henri Dunantstraat 1, 5223 GZ, ‘s-Hertogenbosch, NetherlandsDepartment of Urology, Jeroen Bosch Hospital, Henri Dunantstraat 1, 5223 GZ, ‘s-Hertogenbosch, NetherlandsDepartment of Electrical Engineering, Eindhoven University of Technology, De Rondom 70, 5612 AP, Eindhoven, NetherlandsDepartment of Urology, Jeroen Bosch Hospital, Henri Dunantstraat 1, 5223 GZ, ‘s-Hertogenbosch, NetherlandsDepartment of Radiology, Jeroen Bosch Hospital, Henri Dunantstraat 1, 5223 GZ, ‘s-Hertogenbosch, NetherlandsDepartment of Radiology, Jeroen Bosch Hospital, Henri Dunantstraat 1, 5223 GZ, ‘s-Hertogenbosch, NetherlandsDepartment of Radiology, Jeroen Bosch Hospital, Henri Dunantstraat 1, 5223 GZ, ‘s-Hertogenbosch, NetherlandsDepartment of Urology, Radboudumc University Hospital, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, NetherlandsDepartment of Electrical Engineering, Eindhoven University of Technology, De Rondom 70, 5612 AP, Eindhoven, NetherlandsObjective. To compare prostate cancer detection rates (CDRs) and pathology results with targeted prostate biopsy (TB) and systematic prostate biopsy (SB) in biopsy-naive men. Methods. An in-patient control study of 82 men undergoing SB and subsequent TB in case of positive prostate MRI between 2015 and 2017 in the Jeroen Bosch Hospital, the Netherlands. Results. Prostate cancer (PCa) was detected in 54.9% with 70.7% agreement between TB and SB. Significant PCa (Gleason score ≥7) was detected in 24.4%. The CDR with TB and SB was 35.4% and 48.8%, respectively (p=0.052). The CDR of significant prostate cancer with TB and SB was both 20.7%. Clinically significant pathology upgrading occurred in 7.3% by adding TB to SB and 22.0% by adding SB to TB. Conclusions. There is no statistically significant difference between CDRs of SB and TB. Both SB and TB miss significant PCas. Moreover, pathology upgrading occurred more often by adding SB to TB than vice versa. This indicates that the omission of SB in this study population might not be justified.http://dx.doi.org/10.1155/2020/4626781 |
| spellingShingle | Maudy C. W. Gayet Anouk A. M. A. van der Aa Harrie P. Beerlage Bart Ph Schrier Maaike Gielens Roel Heesakkers Gerrit J. Jager Peter F. A. Mulders Hessel Wijkstra Cancer Detection Rates of Systematic and Targeted Prostate Biopsies after Biparametric MRI Prostate Cancer |
| title | Cancer Detection Rates of Systematic and Targeted Prostate Biopsies after Biparametric MRI |
| title_full | Cancer Detection Rates of Systematic and Targeted Prostate Biopsies after Biparametric MRI |
| title_fullStr | Cancer Detection Rates of Systematic and Targeted Prostate Biopsies after Biparametric MRI |
| title_full_unstemmed | Cancer Detection Rates of Systematic and Targeted Prostate Biopsies after Biparametric MRI |
| title_short | Cancer Detection Rates of Systematic and Targeted Prostate Biopsies after Biparametric MRI |
| title_sort | cancer detection rates of systematic and targeted prostate biopsies after biparametric mri |
| url | http://dx.doi.org/10.1155/2020/4626781 |
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