IgG4-Related Kidney Disease: Report of a Case Presenting as a Renal Mass
IgG4-related disease (IgG4-RD) is a nosological entity defined as a chronic immune-mediated fibro-inflammatory condition characterized by a tendency to form tumefactive, tissue-destructive lesions or by organ failure. Urologic involvement in IgG4-RD has been described in some short series of patient...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Case Reports in Surgery |
| Online Access: | http://dx.doi.org/10.1155/2017/9690218 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560529644716032 |
|---|---|
| author | Daniele Bianchi Luca Topazio Gabriele Gaziev Valerio Iacovelli Pierluigi Bove Alessandro Mauriello Enrico Finazzi Agrò |
| author_facet | Daniele Bianchi Luca Topazio Gabriele Gaziev Valerio Iacovelli Pierluigi Bove Alessandro Mauriello Enrico Finazzi Agrò |
| author_sort | Daniele Bianchi |
| collection | DOAJ |
| description | IgG4-related disease (IgG4-RD) is a nosological entity defined as a chronic immune-mediated fibro-inflammatory condition characterized by a tendency to form tumefactive, tissue-destructive lesions or by organ failure. Urologic involvement in IgG4-RD has been described in some short series of patients and in isolated case reports, most often involving the kidneys in so-called IgG4-related kidney disease (IgG4-RKD). The disease can occasionally mimic malignancies and is at risk of being misdiagnosed due to its rarity. We report the case of a 56-year-old man presenting with a right renal mass suspected of being malignant. Laboratory tests showed normal creatinine levels, a high erythrocyte sedimentation rate, and high levels of C-reactive protein and microalbuminuria. The patient underwent radical right nephroureterectomy and histopathologic examination revealed features proving IgG4-RKD. He was therefore referred to immunologists. Typical clinical presentation of IgG4-RKD includes altered renal function with inconstant or no radiologic findings. Conversely, in the case we presented, a single nodule was detected upon imaging evaluation, thus mimicking malignancy. This raises the issue of a proper differential diagnosis. A multidisciplinary approach can be useful, although in clinical practice the selection of patients suspected of having IgG4-RKD is critical in the cases presenting with a renal mass that mimics malignancy. |
| format | Article |
| id | doaj-art-781fc0241e6a4f619c8c008ac250e76c |
| institution | Kabale University |
| issn | 2090-6900 2090-6919 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Surgery |
| spelling | doaj-art-781fc0241e6a4f619c8c008ac250e76c2025-02-03T01:27:15ZengWileyCase Reports in Surgery2090-69002090-69192017-01-01201710.1155/2017/96902189690218IgG4-Related Kidney Disease: Report of a Case Presenting as a Renal MassDaniele Bianchi0Luca Topazio1Gabriele Gaziev2Valerio Iacovelli3Pierluigi Bove4Alessandro Mauriello5Enrico Finazzi Agrò6Department of Urology, Policlinico Tor Vergata, Rome, ItalyDepartment of Urology, Policlinico Tor Vergata, Rome, ItalyDepartment of Urology, Policlinico Tor Vergata, Rome, ItalyDepartment of Urology, Policlinico Tor Vergata, Rome, ItalyDepartment of Urology, Policlinico Tor Vergata, Rome, ItalyAnatomic Pathology, Department of Experimental Medicine and Surgery, Tor Vergata University, Rome, ItalyDepartment of Urology, Policlinico Tor Vergata, Rome, ItalyIgG4-related disease (IgG4-RD) is a nosological entity defined as a chronic immune-mediated fibro-inflammatory condition characterized by a tendency to form tumefactive, tissue-destructive lesions or by organ failure. Urologic involvement in IgG4-RD has been described in some short series of patients and in isolated case reports, most often involving the kidneys in so-called IgG4-related kidney disease (IgG4-RKD). The disease can occasionally mimic malignancies and is at risk of being misdiagnosed due to its rarity. We report the case of a 56-year-old man presenting with a right renal mass suspected of being malignant. Laboratory tests showed normal creatinine levels, a high erythrocyte sedimentation rate, and high levels of C-reactive protein and microalbuminuria. The patient underwent radical right nephroureterectomy and histopathologic examination revealed features proving IgG4-RKD. He was therefore referred to immunologists. Typical clinical presentation of IgG4-RKD includes altered renal function with inconstant or no radiologic findings. Conversely, in the case we presented, a single nodule was detected upon imaging evaluation, thus mimicking malignancy. This raises the issue of a proper differential diagnosis. A multidisciplinary approach can be useful, although in clinical practice the selection of patients suspected of having IgG4-RKD is critical in the cases presenting with a renal mass that mimics malignancy.http://dx.doi.org/10.1155/2017/9690218 |
| spellingShingle | Daniele Bianchi Luca Topazio Gabriele Gaziev Valerio Iacovelli Pierluigi Bove Alessandro Mauriello Enrico Finazzi Agrò IgG4-Related Kidney Disease: Report of a Case Presenting as a Renal Mass Case Reports in Surgery |
| title | IgG4-Related Kidney Disease: Report of a Case Presenting as a Renal Mass |
| title_full | IgG4-Related Kidney Disease: Report of a Case Presenting as a Renal Mass |
| title_fullStr | IgG4-Related Kidney Disease: Report of a Case Presenting as a Renal Mass |
| title_full_unstemmed | IgG4-Related Kidney Disease: Report of a Case Presenting as a Renal Mass |
| title_short | IgG4-Related Kidney Disease: Report of a Case Presenting as a Renal Mass |
| title_sort | igg4 related kidney disease report of a case presenting as a renal mass |
| url | http://dx.doi.org/10.1155/2017/9690218 |
| work_keys_str_mv | AT danielebianchi igg4relatedkidneydiseasereportofacasepresentingasarenalmass AT lucatopazio igg4relatedkidneydiseasereportofacasepresentingasarenalmass AT gabrielegaziev igg4relatedkidneydiseasereportofacasepresentingasarenalmass AT valerioiacovelli igg4relatedkidneydiseasereportofacasepresentingasarenalmass AT pierluigibove igg4relatedkidneydiseasereportofacasepresentingasarenalmass AT alessandromauriello igg4relatedkidneydiseasereportofacasepresentingasarenalmass AT enricofinazziagro igg4relatedkidneydiseasereportofacasepresentingasarenalmass |