Anti-PL-7/PL-12 antisynthetase syndrome associated with interstitial lung disease following SARS-COV-2 infection and vaccination: A case study review
Cumulative evidence suggests a link between specific autoimmune diseases (AD), including idiopathic inflammatory myopathies (IIM), and SARS-CoV-2 infection or COVID-19 vaccination. Anti-synthetase syndrome (ASS), a subset of IIM, is defined by the presence of autoantibodies against aminoacyl-tRNA sy...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024173422 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832573154032091136 |
|---|---|
| author | Laura García-Bravo Ángela Villegas Bárbara López Uceda Anaís Mariscal Cristina Vadillo M Asunción Nieto Barbero Juan Luis Rodríguez-Hermosa Beatriz Mediero Valeros José Carlos Plaza-Hernández Miguel Fernández-Arquero María Guzmán-Fulgencio Gloria Candelas-Rodríguez Silvia Sánchez-Ramón Juliana Ochoa-Grullón |
| author_facet | Laura García-Bravo Ángela Villegas Bárbara López Uceda Anaís Mariscal Cristina Vadillo M Asunción Nieto Barbero Juan Luis Rodríguez-Hermosa Beatriz Mediero Valeros José Carlos Plaza-Hernández Miguel Fernández-Arquero María Guzmán-Fulgencio Gloria Candelas-Rodríguez Silvia Sánchez-Ramón Juliana Ochoa-Grullón |
| author_sort | Laura García-Bravo |
| collection | DOAJ |
| description | Cumulative evidence suggests a link between specific autoimmune diseases (AD), including idiopathic inflammatory myopathies (IIM), and SARS-CoV-2 infection or COVID-19 vaccination. Anti-synthetase syndrome (ASS), a subset of IIM, is defined by the presence of autoantibodies against aminoacyl-tRNA synthetase (anti-ARS) and is strongly associated with interstitial lung disease (ILD), a major contributor to severe complications and reduced survival. We present four clinical cases of patients who developed autoantibodies against threonyl (PL-7) and alanyl (PL-12) synthetases associated with ASS-ILD shortly after SARS-CoV-2 infection or COVID-19 vaccination. Anti-ARS autoantibodies were identified using three complementary methods: immunoblotting, western blotting (WB) and the method considered the gold standard, immunoprecipitation (IP), which ensures accurate interpretation of results. The study highlights the clinical and pathogenic overlap between ASS-ILD and SARS-CoV-2-related lung involvement.Both conditions share similar high-resolution computed tomography (HRCT) patterns, including inflammation and pulmonary fibrosis (PF), driven by IFN-γ signaling, which complicates accurate diagnosis. Our results provide novel insights into the temporal association of SARS-CoV-2 and vaccine exposure with ASS-ILD, focusing on possible molecular mimicry between viral proteins and ARS molecules as a potential mechanism. Understanding the involvement of specific anti-ARS autoantibodies (PL-7 and PL-12) and the identification of genetic predispositions (HLA-B∗08:01 and HLA-DRB1∗03:01) in these patients may be key to underpinning these autoimmune manifestations. The study underscores the importance of a multidisciplinary approach and vigilant follow-up to optimize diagnosis and management. Further research is essential to elucidate the causal relationships and molecular mechanisms behind these observations. |
| format | Article |
| id | doaj-art-7818cd02cef14a8181b2c537cf59ca18 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-7818cd02cef14a8181b2c537cf59ca182025-02-02T05:27:46ZengElsevierHeliyon2405-84402025-01-01112e41311Anti-PL-7/PL-12 antisynthetase syndrome associated with interstitial lung disease following SARS-COV-2 infection and vaccination: A case study reviewLaura García-Bravo0Ángela Villegas1Bárbara López Uceda2Anaís Mariscal3Cristina Vadillo4M Asunción Nieto Barbero5Juan Luis Rodríguez-Hermosa6Beatriz Mediero Valeros7José Carlos Plaza-Hernández8Miguel Fernández-Arquero9María Guzmán-Fulgencio10Gloria Candelas-Rodríguez11Silvia Sánchez-Ramón12Juliana Ochoa-Grullón13Immunology Department and IdISSC, Hospital Clínico San Carlos, 28040, Madrid, SpainImmunology Department and IdISSC, Hospital Clínico San Carlos, 28040, Madrid, SpainImmunology Department and IdISSC, Hospital Clínico San Carlos, 28040, Madrid, SpainImmunology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Biomedical Research Institute Sant Pau (IIB Sant Pau), 08041, Barcelona, SpainRheumatology Department, Hospital Clínico San Carlos, 28040, Madrid, SpainPneumology Department and IdISSC, Hospital Clínico San Carlos, 28040, Madrid, SpainPneumology Department and IdISSC, Hospital Clínico San Carlos, 28040, Madrid, SpainImmunology Department and IdISSC, Hospital Clínico San Carlos, 28040, Madrid, SpainPathological Anatomy Department, 28040, Madrid, SpainImmunology Department and IdISSC, Hospital Clínico San Carlos, 28040, Madrid, SpainImmunology Department and IdISSC, Hospital Clínico San Carlos, 28040, Madrid, SpainRheumatology Department, Hospital Clínico San Carlos, 28040, Madrid, SpainImmunology Department and IdISSC, Hospital Clínico San Carlos, 28040, Madrid, SpainImmunology Department and IdISSC, Hospital Clínico San Carlos, 28040, Madrid, Spain; Corresponding author.Cumulative evidence suggests a link between specific autoimmune diseases (AD), including idiopathic inflammatory myopathies (IIM), and SARS-CoV-2 infection or COVID-19 vaccination. Anti-synthetase syndrome (ASS), a subset of IIM, is defined by the presence of autoantibodies against aminoacyl-tRNA synthetase (anti-ARS) and is strongly associated with interstitial lung disease (ILD), a major contributor to severe complications and reduced survival. We present four clinical cases of patients who developed autoantibodies against threonyl (PL-7) and alanyl (PL-12) synthetases associated with ASS-ILD shortly after SARS-CoV-2 infection or COVID-19 vaccination. Anti-ARS autoantibodies were identified using three complementary methods: immunoblotting, western blotting (WB) and the method considered the gold standard, immunoprecipitation (IP), which ensures accurate interpretation of results. The study highlights the clinical and pathogenic overlap between ASS-ILD and SARS-CoV-2-related lung involvement.Both conditions share similar high-resolution computed tomography (HRCT) patterns, including inflammation and pulmonary fibrosis (PF), driven by IFN-γ signaling, which complicates accurate diagnosis. Our results provide novel insights into the temporal association of SARS-CoV-2 and vaccine exposure with ASS-ILD, focusing on possible molecular mimicry between viral proteins and ARS molecules as a potential mechanism. Understanding the involvement of specific anti-ARS autoantibodies (PL-7 and PL-12) and the identification of genetic predispositions (HLA-B∗08:01 and HLA-DRB1∗03:01) in these patients may be key to underpinning these autoimmune manifestations. The study underscores the importance of a multidisciplinary approach and vigilant follow-up to optimize diagnosis and management. Further research is essential to elucidate the causal relationships and molecular mechanisms behind these observations.http://www.sciencedirect.com/science/article/pii/S2405844024173422Idiopathic inflammatory myopathiesAnti-synthetase syndromeInterstitial lung diseaseCOVID-19SARS-CoV-2 vaccine |
| spellingShingle | Laura García-Bravo Ángela Villegas Bárbara López Uceda Anaís Mariscal Cristina Vadillo M Asunción Nieto Barbero Juan Luis Rodríguez-Hermosa Beatriz Mediero Valeros José Carlos Plaza-Hernández Miguel Fernández-Arquero María Guzmán-Fulgencio Gloria Candelas-Rodríguez Silvia Sánchez-Ramón Juliana Ochoa-Grullón Anti-PL-7/PL-12 antisynthetase syndrome associated with interstitial lung disease following SARS-COV-2 infection and vaccination: A case study review Heliyon Idiopathic inflammatory myopathies Anti-synthetase syndrome Interstitial lung disease COVID-19 SARS-CoV-2 vaccine |
| title | Anti-PL-7/PL-12 antisynthetase syndrome associated with interstitial lung disease following SARS-COV-2 infection and vaccination: A case study review |
| title_full | Anti-PL-7/PL-12 antisynthetase syndrome associated with interstitial lung disease following SARS-COV-2 infection and vaccination: A case study review |
| title_fullStr | Anti-PL-7/PL-12 antisynthetase syndrome associated with interstitial lung disease following SARS-COV-2 infection and vaccination: A case study review |
| title_full_unstemmed | Anti-PL-7/PL-12 antisynthetase syndrome associated with interstitial lung disease following SARS-COV-2 infection and vaccination: A case study review |
| title_short | Anti-PL-7/PL-12 antisynthetase syndrome associated with interstitial lung disease following SARS-COV-2 infection and vaccination: A case study review |
| title_sort | anti pl 7 pl 12 antisynthetase syndrome associated with interstitial lung disease following sars cov 2 infection and vaccination a case study review |
| topic | Idiopathic inflammatory myopathies Anti-synthetase syndrome Interstitial lung disease COVID-19 SARS-CoV-2 vaccine |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024173422 |
| work_keys_str_mv | AT lauragarciabravo antipl7pl12antisynthetasesyndromeassociatedwithinterstitiallungdiseasefollowingsarscov2infectionandvaccinationacasestudyreview AT angelavillegas antipl7pl12antisynthetasesyndromeassociatedwithinterstitiallungdiseasefollowingsarscov2infectionandvaccinationacasestudyreview AT barbaralopezuceda antipl7pl12antisynthetasesyndromeassociatedwithinterstitiallungdiseasefollowingsarscov2infectionandvaccinationacasestudyreview AT anaismariscal antipl7pl12antisynthetasesyndromeassociatedwithinterstitiallungdiseasefollowingsarscov2infectionandvaccinationacasestudyreview AT cristinavadillo antipl7pl12antisynthetasesyndromeassociatedwithinterstitiallungdiseasefollowingsarscov2infectionandvaccinationacasestudyreview AT masuncionnietobarbero antipl7pl12antisynthetasesyndromeassociatedwithinterstitiallungdiseasefollowingsarscov2infectionandvaccinationacasestudyreview AT juanluisrodriguezhermosa antipl7pl12antisynthetasesyndromeassociatedwithinterstitiallungdiseasefollowingsarscov2infectionandvaccinationacasestudyreview AT beatrizmedierovaleros antipl7pl12antisynthetasesyndromeassociatedwithinterstitiallungdiseasefollowingsarscov2infectionandvaccinationacasestudyreview AT josecarlosplazahernandez antipl7pl12antisynthetasesyndromeassociatedwithinterstitiallungdiseasefollowingsarscov2infectionandvaccinationacasestudyreview AT miguelfernandezarquero antipl7pl12antisynthetasesyndromeassociatedwithinterstitiallungdiseasefollowingsarscov2infectionandvaccinationacasestudyreview AT mariaguzmanfulgencio antipl7pl12antisynthetasesyndromeassociatedwithinterstitiallungdiseasefollowingsarscov2infectionandvaccinationacasestudyreview AT gloriacandelasrodriguez antipl7pl12antisynthetasesyndromeassociatedwithinterstitiallungdiseasefollowingsarscov2infectionandvaccinationacasestudyreview AT silviasanchezramon antipl7pl12antisynthetasesyndromeassociatedwithinterstitiallungdiseasefollowingsarscov2infectionandvaccinationacasestudyreview AT julianaochoagrullon antipl7pl12antisynthetasesyndromeassociatedwithinterstitiallungdiseasefollowingsarscov2infectionandvaccinationacasestudyreview |