Thyroid-Disrupting Activities of Groundwater from a Riverbank Filtration System in Wuchang City, China: Seasonal Distribution and Human Health Risk Assessment
The recombinant thyroid hormone receptor (TR) gene yeast assay was used to evaluate thyroid disruption caused by groundwater from the riverbank filtration (RBF) system in Wuchang City, China. To investigate seasonal fluctuations, groundwater was collected during three seasons. Although no TR agonist...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2020/2437082 |
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| author | Dongdong Kong Hedan Liu Yun Liu Yafei Wang Jian Li |
| author_facet | Dongdong Kong Hedan Liu Yun Liu Yafei Wang Jian Li |
| author_sort | Dongdong Kong |
| collection | DOAJ |
| description | The recombinant thyroid hormone receptor (TR) gene yeast assay was used to evaluate thyroid disruption caused by groundwater from the riverbank filtration (RBF) system in Wuchang City, China. To investigate seasonal fluctuations, groundwater was collected during three seasons. Although no TR agonistic activity was found, many water samples exhibited TR antagonistic activity. The bioassay-derived amiodarone hydrochloride (AH) equivalents ranged from 2.99 to 274.40 μg/L. Water samples collected from the riverbank filtration system during the dry season had higher TR antagonistic activity. All samples presented adverse 3,3′,5-triiodo-L-thyronine (T3) equivalent levels, ranging from −2.00 to −2.12 μg/kg. Following exposure to water samples with substantial TR antagonist activity, predicted hormonal changes in humans of different gender and age ranged from 0.65 to 1.48 μg/kg of T3, being 47% to 231% of normal. No obvious difference was found between genders or among age groups. Overall, the results revealed that the RBF system could remove the thyroid-disrupting chemicals in the river water to some extent. Considering the varying degrees of risk to human health, further treatment is needed to remove the potential thyroid-disrupting chemicals in pumping water after riverbank filtration to ensure drinking water safety. |
| format | Article |
| id | doaj-art-7810b30e7a1e4b68ad053624793ed187 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
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| series | Journal of Chemistry |
| spelling | doaj-art-7810b30e7a1e4b68ad053624793ed1872025-02-03T05:51:46ZengWileyJournal of Chemistry2090-90632090-90712020-01-01202010.1155/2020/24370822437082Thyroid-Disrupting Activities of Groundwater from a Riverbank Filtration System in Wuchang City, China: Seasonal Distribution and Human Health Risk AssessmentDongdong Kong0Hedan Liu1Yun Liu2Yafei Wang3Jian Li4Engineering Research Center of Groundwater Pollution Control and Remediation, Ministry of Education, College of Water Sciences, Beijing Normal University, Beijing 100875, ChinaEngineering Research Center of Groundwater Pollution Control and Remediation, Ministry of Education, College of Water Sciences, Beijing Normal University, Beijing 100875, ChinaSouth China Institute of Environmental Science, MEE, No. 7 West Street, Yuancun, Guangzhou 510655, ChinaEngineering Research Center of Groundwater Pollution Control and Remediation, Ministry of Education, College of Water Sciences, Beijing Normal University, Beijing 100875, ChinaEngineering Research Center of Groundwater Pollution Control and Remediation, Ministry of Education, College of Water Sciences, Beijing Normal University, Beijing 100875, ChinaThe recombinant thyroid hormone receptor (TR) gene yeast assay was used to evaluate thyroid disruption caused by groundwater from the riverbank filtration (RBF) system in Wuchang City, China. To investigate seasonal fluctuations, groundwater was collected during three seasons. Although no TR agonistic activity was found, many water samples exhibited TR antagonistic activity. The bioassay-derived amiodarone hydrochloride (AH) equivalents ranged from 2.99 to 274.40 μg/L. Water samples collected from the riverbank filtration system during the dry season had higher TR antagonistic activity. All samples presented adverse 3,3′,5-triiodo-L-thyronine (T3) equivalent levels, ranging from −2.00 to −2.12 μg/kg. Following exposure to water samples with substantial TR antagonist activity, predicted hormonal changes in humans of different gender and age ranged from 0.65 to 1.48 μg/kg of T3, being 47% to 231% of normal. No obvious difference was found between genders or among age groups. Overall, the results revealed that the RBF system could remove the thyroid-disrupting chemicals in the river water to some extent. Considering the varying degrees of risk to human health, further treatment is needed to remove the potential thyroid-disrupting chemicals in pumping water after riverbank filtration to ensure drinking water safety.http://dx.doi.org/10.1155/2020/2437082 |
| spellingShingle | Dongdong Kong Hedan Liu Yun Liu Yafei Wang Jian Li Thyroid-Disrupting Activities of Groundwater from a Riverbank Filtration System in Wuchang City, China: Seasonal Distribution and Human Health Risk Assessment Journal of Chemistry |
| title | Thyroid-Disrupting Activities of Groundwater from a Riverbank Filtration System in Wuchang City, China: Seasonal Distribution and Human Health Risk Assessment |
| title_full | Thyroid-Disrupting Activities of Groundwater from a Riverbank Filtration System in Wuchang City, China: Seasonal Distribution and Human Health Risk Assessment |
| title_fullStr | Thyroid-Disrupting Activities of Groundwater from a Riverbank Filtration System in Wuchang City, China: Seasonal Distribution and Human Health Risk Assessment |
| title_full_unstemmed | Thyroid-Disrupting Activities of Groundwater from a Riverbank Filtration System in Wuchang City, China: Seasonal Distribution and Human Health Risk Assessment |
| title_short | Thyroid-Disrupting Activities of Groundwater from a Riverbank Filtration System in Wuchang City, China: Seasonal Distribution and Human Health Risk Assessment |
| title_sort | thyroid disrupting activities of groundwater from a riverbank filtration system in wuchang city china seasonal distribution and human health risk assessment |
| url | http://dx.doi.org/10.1155/2020/2437082 |
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