Size exclusion chromatography as green support for forced degradation study of adalimumab
Size exclusion chromatography (SEC) has become a powerful tool for analysing size variants of biologic drugs in their native form. Modern SEC can be defined by the use of chromatographic columns packed with sub-3 µm particles, allowing an increase in method throughput compared to that of conventiona...
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| Format: | Article |
| Language: | English |
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Sciendo
2023-12-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2023-0044 |
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| _version_ | 1832545929268297728 |
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| author | Kovačić Jelena Klarić Daniela Amidžić Turk Nikša Mornar Ana |
| author_facet | Kovačić Jelena Klarić Daniela Amidžić Turk Nikša Mornar Ana |
| author_sort | Kovačić Jelena |
| collection | DOAJ |
| description | Size exclusion chromatography (SEC) has become a powerful tool for analysing size variants of biologic drugs in their native form. Modern SEC can be defined by the use of chromatographic columns packed with sub-3 µm particles, allowing an increase in method throughput compared to that of conventional SEC. |
| format | Article |
| id | doaj-art-780f2056885f45faa158c1c59dcb6b0e |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-780f2056885f45faa158c1c59dcb6b0e2025-02-03T07:24:17ZengSciendoActa Pharmaceutica1846-95582023-12-0173470972110.2478/acph-2023-0044Size exclusion chromatography as green support for forced degradation study of adalimumabKovačić Jelena0Klarić Daniela Amidžić1Turk Nikša2Mornar Ana31University of Zagreb, Faculty of Pharmacy and Biochemistry Department of Pharmaceutical Analysis, 10000Zagreb, Croatia1University of Zagreb, Faculty of Pharmacy and Biochemistry Department of Pharmaceutical Analysis, 10000Zagreb, Croatia2Clinical Hospital ZagrebDepartment of Gastroenterology, 10000ZagrebCroatia1University of Zagreb, Faculty of Pharmacy and Biochemistry Department of Pharmaceutical Analysis, 10000Zagreb, CroatiaSize exclusion chromatography (SEC) has become a powerful tool for analysing size variants of biologic drugs in their native form. Modern SEC can be defined by the use of chromatographic columns packed with sub-3 µm particles, allowing an increase in method throughput compared to that of conventional SEC.https://doi.org/10.2478/acph-2023-0044inflammatory bowel diseasebiopharmaceuticalsadalimumabsize exclusion chromatographyforced degradation study |
| spellingShingle | Kovačić Jelena Klarić Daniela Amidžić Turk Nikša Mornar Ana Size exclusion chromatography as green support for forced degradation study of adalimumab Acta Pharmaceutica inflammatory bowel disease biopharmaceuticals adalimumab size exclusion chromatography forced degradation study |
| title | Size exclusion chromatography as green support for forced degradation study of adalimumab |
| title_full | Size exclusion chromatography as green support for forced degradation study of adalimumab |
| title_fullStr | Size exclusion chromatography as green support for forced degradation study of adalimumab |
| title_full_unstemmed | Size exclusion chromatography as green support for forced degradation study of adalimumab |
| title_short | Size exclusion chromatography as green support for forced degradation study of adalimumab |
| title_sort | size exclusion chromatography as green support for forced degradation study of adalimumab |
| topic | inflammatory bowel disease biopharmaceuticals adalimumab size exclusion chromatography forced degradation study |
| url | https://doi.org/10.2478/acph-2023-0044 |
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