COX-2 Inhibitors and Gastric Cancer
The evidence that cyclooxygenase-2 (COX-2) is upregulated and plays an important role in carcinogenesis of gastric cancer has triggered the topic of COX-2 inhibitors as chemopreventive agents for gastric cancer. Studies find that COX-2 inhibitors are associated not only with chemoprophylactic effect...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2014/132320 |
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| _version_ | 1832548549124947968 |
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| author | Zhen Wang Jun-qiang Chen Jin-lu Liu |
| author_facet | Zhen Wang Jun-qiang Chen Jin-lu Liu |
| author_sort | Zhen Wang |
| collection | DOAJ |
| description | The evidence that cyclooxygenase-2 (COX-2) is upregulated and plays an important role in carcinogenesis of gastric cancer has triggered the topic of COX-2 inhibitors as chemopreventive agents for gastric cancer. Studies find that COX-2 inhibitors are associated not only with chemoprophylactic effects, but also with chemotherapeutic potentials in gastric cancer. Both COX-dependent and COX-independent pathways have a role in the anticancer efficiency of COX-2 inhibitors. However, enthusiasm is thwarted by the potential toxicity, that is, gastrointestinal toxicity of nonselective COX-2 inhibitors and cardiovascular risk of selective COX-2 inhibitors. Therefore, more studies are needed to develop new targeted antitumor agents (such as prostaglandin E receptor antagonist) and to define fundamental questions such as optimal treatment regimens, integration of cotherapy, and careful selection of candidates. |
| format | Article |
| id | doaj-art-7804ee9297394601b9f3c906e878bd8a |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-7804ee9297394601b9f3c906e878bd8a2025-02-03T06:13:50ZengWileyGastroenterology Research and Practice1687-61211687-630X2014-01-01201410.1155/2014/132320132320COX-2 Inhibitors and Gastric CancerZhen Wang0Jun-qiang Chen1Jin-lu Liu2Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region 530021, ChinaDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region 530021, ChinaDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region 530021, ChinaThe evidence that cyclooxygenase-2 (COX-2) is upregulated and plays an important role in carcinogenesis of gastric cancer has triggered the topic of COX-2 inhibitors as chemopreventive agents for gastric cancer. Studies find that COX-2 inhibitors are associated not only with chemoprophylactic effects, but also with chemotherapeutic potentials in gastric cancer. Both COX-dependent and COX-independent pathways have a role in the anticancer efficiency of COX-2 inhibitors. However, enthusiasm is thwarted by the potential toxicity, that is, gastrointestinal toxicity of nonselective COX-2 inhibitors and cardiovascular risk of selective COX-2 inhibitors. Therefore, more studies are needed to develop new targeted antitumor agents (such as prostaglandin E receptor antagonist) and to define fundamental questions such as optimal treatment regimens, integration of cotherapy, and careful selection of candidates.http://dx.doi.org/10.1155/2014/132320 |
| spellingShingle | Zhen Wang Jun-qiang Chen Jin-lu Liu COX-2 Inhibitors and Gastric Cancer Gastroenterology Research and Practice |
| title | COX-2 Inhibitors and Gastric Cancer |
| title_full | COX-2 Inhibitors and Gastric Cancer |
| title_fullStr | COX-2 Inhibitors and Gastric Cancer |
| title_full_unstemmed | COX-2 Inhibitors and Gastric Cancer |
| title_short | COX-2 Inhibitors and Gastric Cancer |
| title_sort | cox 2 inhibitors and gastric cancer |
| url | http://dx.doi.org/10.1155/2014/132320 |
| work_keys_str_mv | AT zhenwang cox2inhibitorsandgastriccancer AT junqiangchen cox2inhibitorsandgastriccancer AT jinluliu cox2inhibitorsandgastriccancer |