Synthesis of Enantiostructured Triacylglycerol Prodrugs Constituting an Active Drug Located at Terminal <i>sn</i>-1 and <i>sn</i>-3 Positions of the Glycerol Backbone

Synthesis of Enantiostructured Triacylglycerol Prodrugs Constituting an Active Drug Located at Terminal <i>sn</i>-1 and <i>sn</i>-3 Positions of the Glycerol Backbone

The current paper reports the asymmetric synthesis of a focused library of enantiostructured triacylglycerols (TAGs) constituting a potent drug of the NSAID type (ibuprofen or naproxen) along with a pure bioactive n-3 polyunsaturated fatty acid (PUFA) intended as a novel type of prodrug. In this sec...

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Bibliographic Details
Main Authors: Lena Rós Jónsdottir, Gudmundur G. Haraldsson
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Molecules
Subjects:
asymmetric synthesis
enantiostructured triacylglycerols
lipase
n-3 PUFAs
acylglycerol prodrugs
(<i>S</i>)-ibuprofen
Online Access:https://www.mdpi.com/1420-3049/30/5/991
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