Cellular Stress Responses: Cell Survival and Cell Death
Cells can respond to stress in various ways ranging from the activation of survival pathways to the initiation of cell death that eventually eliminates damaged cells. Whether cells mount a protective or destructive stress response depends to a large extent on the nature and duration of the stress as...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2010/214074 |
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| _version_ | 1832551814609764352 |
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| author | Simone Fulda Adrienne M. Gorman Osamu Hori Afshin Samali |
| author_facet | Simone Fulda Adrienne M. Gorman Osamu Hori Afshin Samali |
| author_sort | Simone Fulda |
| collection | DOAJ |
| description | Cells can respond to stress in various ways ranging from the activation of survival pathways to the initiation of cell death that eventually eliminates damaged cells. Whether cells mount a protective or destructive stress response depends to a large extent on the nature and duration of the stress as well as the cell type. Also, there is often the interplay between these responses that ultimately determines the fate of the stressed cell. The mechanism by which a cell dies (i.e., apoptosis, necrosis, pyroptosis, or autophagic cell death) depends on various exogenous factors as well as the cell's ability to handle the stress to which it is exposed. The implications of cellular stress responses to human physiology and diseases are manifold and will be discussed in this review in the context of some major world health issues such as diabetes, Parkinson's disease, myocardial infarction, and cancer. |
| format | Article |
| id | doaj-art-77e5fa1c812e47c08de13962e79513d5 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-77e5fa1c812e47c08de13962e79513d52025-02-03T06:00:31ZengWileyInternational Journal of Cell Biology1687-88761687-88842010-01-01201010.1155/2010/214074214074Cellular Stress Responses: Cell Survival and Cell DeathSimone Fulda0Adrienne M. Gorman1Osamu Hori2Afshin Samali3Children's Hospital, Ulm University, Eythstraße. 24, 89075 Ulm, GermanySchool of Natural Sciences, National University of Ireland, Galway, University Road, Galway, IrelandKanazawa University Graduate School of Medical Science, Department of Neuroanatomy, Kanazawa City, Ishikawa, 920-8640 Japan, JapanSchool of Natural Sciences, National University of Ireland, Galway, University Road, Galway, IrelandCells can respond to stress in various ways ranging from the activation of survival pathways to the initiation of cell death that eventually eliminates damaged cells. Whether cells mount a protective or destructive stress response depends to a large extent on the nature and duration of the stress as well as the cell type. Also, there is often the interplay between these responses that ultimately determines the fate of the stressed cell. The mechanism by which a cell dies (i.e., apoptosis, necrosis, pyroptosis, or autophagic cell death) depends on various exogenous factors as well as the cell's ability to handle the stress to which it is exposed. The implications of cellular stress responses to human physiology and diseases are manifold and will be discussed in this review in the context of some major world health issues such as diabetes, Parkinson's disease, myocardial infarction, and cancer.http://dx.doi.org/10.1155/2010/214074 |
| spellingShingle | Simone Fulda Adrienne M. Gorman Osamu Hori Afshin Samali Cellular Stress Responses: Cell Survival and Cell Death International Journal of Cell Biology |
| title | Cellular Stress Responses: Cell Survival and Cell Death |
| title_full | Cellular Stress Responses: Cell Survival and Cell Death |
| title_fullStr | Cellular Stress Responses: Cell Survival and Cell Death |
| title_full_unstemmed | Cellular Stress Responses: Cell Survival and Cell Death |
| title_short | Cellular Stress Responses: Cell Survival and Cell Death |
| title_sort | cellular stress responses cell survival and cell death |
| url | http://dx.doi.org/10.1155/2010/214074 |
| work_keys_str_mv | AT simonefulda cellularstressresponsescellsurvivalandcelldeath AT adriennemgorman cellularstressresponsescellsurvivalandcelldeath AT osamuhori cellularstressresponsescellsurvivalandcelldeath AT afshinsamali cellularstressresponsescellsurvivalandcelldeath |