Virtual Screening as a Technique for PPAR Modulator Discovery
Virtual screening (VS) is a discovery technique to identify novel compounds with therapeutic and preventive efficacy against disease. Our current focus is on the in silico screening and discovery of novel peroxisome proliferator-activated receptor-gamma (PPARγ) agonists. It is well recognized that P...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2010/861238 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559288461033472 |
|---|---|
| author | Stephanie N. Lewis Josep Bassaganya-Riera David R. Bevan |
| author_facet | Stephanie N. Lewis Josep Bassaganya-Riera David R. Bevan |
| author_sort | Stephanie N. Lewis |
| collection | DOAJ |
| description | Virtual screening (VS) is a discovery technique to identify novel compounds with therapeutic and preventive efficacy against disease. Our current focus is on the in silico screening and discovery of novel peroxisome proliferator-activated receptor-gamma (PPARγ) agonists. It is well recognized that PPARγ
agonists have therapeutic applications as insulin sensitizers in type 2 diabetes or as anti-inflammatories. VS is a cost- and time-effective means for identifying small molecules that have therapeutic potential. Our long-term goal is to devise computational approaches for testing the PPARγ-binding activity of extensive naturally occurring compound libraries prior to testing agonist activity using ligand-binding and reporter assays. This review summarizes the high potential for obtaining further fundamental understanding of PPARγ
biology and development of novel therapies for treating chronic inflammatory diseases through evolution and implementation of computational screening processes for immunotherapeutics in conjunction with experimental methods for calibration and validation of results. |
| format | Article |
| id | doaj-art-77da6bc4910b41649c31a9a98c409825 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-77da6bc4910b41649c31a9a98c4098252025-02-03T01:30:29ZengWileyPPAR Research1687-47571687-47652010-01-01201010.1155/2010/861238861238Virtual Screening as a Technique for PPAR Modulator DiscoveryStephanie N. Lewis0Josep Bassaganya-Riera1David R. Bevan2Genetics, Bioinformatics, and Computational Biology Program, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USANutritional Immunology and Molecular Nutrition, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Washington Street 0477, Blacksburg, VA 24061, USADepartment of Biochemistry, Virginia Polytechnic Institute and State University, 201 Engel Hall 0308, Blacksburg, VA 24061, USAVirtual screening (VS) is a discovery technique to identify novel compounds with therapeutic and preventive efficacy against disease. Our current focus is on the in silico screening and discovery of novel peroxisome proliferator-activated receptor-gamma (PPARγ) agonists. It is well recognized that PPARγ agonists have therapeutic applications as insulin sensitizers in type 2 diabetes or as anti-inflammatories. VS is a cost- and time-effective means for identifying small molecules that have therapeutic potential. Our long-term goal is to devise computational approaches for testing the PPARγ-binding activity of extensive naturally occurring compound libraries prior to testing agonist activity using ligand-binding and reporter assays. This review summarizes the high potential for obtaining further fundamental understanding of PPARγ biology and development of novel therapies for treating chronic inflammatory diseases through evolution and implementation of computational screening processes for immunotherapeutics in conjunction with experimental methods for calibration and validation of results.http://dx.doi.org/10.1155/2010/861238 |
| spellingShingle | Stephanie N. Lewis Josep Bassaganya-Riera David R. Bevan Virtual Screening as a Technique for PPAR Modulator Discovery PPAR Research |
| title | Virtual Screening as a Technique for PPAR Modulator Discovery |
| title_full | Virtual Screening as a Technique for PPAR Modulator Discovery |
| title_fullStr | Virtual Screening as a Technique for PPAR Modulator Discovery |
| title_full_unstemmed | Virtual Screening as a Technique for PPAR Modulator Discovery |
| title_short | Virtual Screening as a Technique for PPAR Modulator Discovery |
| title_sort | virtual screening as a technique for ppar modulator discovery |
| url | http://dx.doi.org/10.1155/2010/861238 |
| work_keys_str_mv | AT stephanienlewis virtualscreeningasatechniqueforpparmodulatordiscovery AT josepbassaganyariera virtualscreeningasatechniqueforpparmodulatordiscovery AT davidrbevan virtualscreeningasatechniqueforpparmodulatordiscovery |