Association between non-alcoholic fatty liver disease and progression of abdominal aortic aneurysm: a multicenter study
Abstract Background The purpose of our study was to investigate the association between non-alcoholic fatty liver disease (NAFLD) and abdominal aortic aneurysms (AAA) progression using non-enhanced computed tomography (CT) and CT angiography (CTA). Methods Patients with AAA and age- and sex-matched...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12880-025-01559-7 |
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| author | Ximing Wang Jingxiang Sun Na Chang Menghan Liu Shuai Zhang |
| author_facet | Ximing Wang Jingxiang Sun Na Chang Menghan Liu Shuai Zhang |
| author_sort | Ximing Wang |
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| description | Abstract Background The purpose of our study was to investigate the association between non-alcoholic fatty liver disease (NAFLD) and abdominal aortic aneurysms (AAA) progression using non-enhanced computed tomography (CT) and CT angiography (CTA). Methods Patients with AAA and age- and sex-matched healthy subjects who underwent abdominal CTA and non-enhanced CT examination between January 2015 and January 2023 from four hospitals were retrospectively analyzed. Patients with AAA were divided into progression (growth rate > 10 mL/year) and non-progression groups, as well as those with NAFLD and without NAFLD, based on abdominal CT results. The Kaplan-Meier and Cox regression were used to investigate the association between NAFLD and AAA progression. Results A total of 151 patients with AAA (mean age: 69.1 ± 10.5 years old, 133 men) were included, among which 66 patients (43.7%) had NAFLD. During a median of 10.7 months (6.0–76.0 months), 57 patients (37.7%) had AAA progression. The prevalence of NAFLD was significantly higher in the AAA group compared to the control group (43.7% vs. 31.1%, p = 0.024). Multivariable regression analysis revealed that the NAFLD was independently associated with AAA progression (HR, 4.28; 95% CI, 2.20–8.31; p < 0.001). The area under curve of combined NAFLD and AAA maximal diameter was 0.857 for predicting AAA progression. Conclusions NAFLD on non-enhanced CT is an independent predictor of AAA progression. It can improve the diagnostic efficacy of predicting the progression of abdominal aortic aneurysms. Clinical trial number Not applicable. This research is a retrospective analysis. |
| format | Article |
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| institution | Kabale University |
| issn | 1471-2342 |
| language | English |
| publishDate | 2025-01-01 |
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| series | BMC Medical Imaging |
| spelling | doaj-art-77d1d41e37aa4e8191f819b4ce895b702025-01-26T12:57:57ZengBMCBMC Medical Imaging1471-23422025-01-012511910.1186/s12880-025-01559-7Association between non-alcoholic fatty liver disease and progression of abdominal aortic aneurysm: a multicenter studyXiming Wang0Jingxiang Sun1Na Chang2Menghan Liu3Shuai Zhang4Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityDepartment of Radiology, The First Affiliated Hospital of Shandong First Medical UniversityDepartment of Medical Technology, Jinan Nursing Vocational CollegeDepartment of Health Management, The First Affiliated Hospital of Shandong First Medical UniversityDepartment of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityAbstract Background The purpose of our study was to investigate the association between non-alcoholic fatty liver disease (NAFLD) and abdominal aortic aneurysms (AAA) progression using non-enhanced computed tomography (CT) and CT angiography (CTA). Methods Patients with AAA and age- and sex-matched healthy subjects who underwent abdominal CTA and non-enhanced CT examination between January 2015 and January 2023 from four hospitals were retrospectively analyzed. Patients with AAA were divided into progression (growth rate > 10 mL/year) and non-progression groups, as well as those with NAFLD and without NAFLD, based on abdominal CT results. The Kaplan-Meier and Cox regression were used to investigate the association between NAFLD and AAA progression. Results A total of 151 patients with AAA (mean age: 69.1 ± 10.5 years old, 133 men) were included, among which 66 patients (43.7%) had NAFLD. During a median of 10.7 months (6.0–76.0 months), 57 patients (37.7%) had AAA progression. The prevalence of NAFLD was significantly higher in the AAA group compared to the control group (43.7% vs. 31.1%, p = 0.024). Multivariable regression analysis revealed that the NAFLD was independently associated with AAA progression (HR, 4.28; 95% CI, 2.20–8.31; p < 0.001). The area under curve of combined NAFLD and AAA maximal diameter was 0.857 for predicting AAA progression. Conclusions NAFLD on non-enhanced CT is an independent predictor of AAA progression. It can improve the diagnostic efficacy of predicting the progression of abdominal aortic aneurysms. Clinical trial number Not applicable. This research is a retrospective analysis.https://doi.org/10.1186/s12880-025-01559-7Non-alcoholic fatty liver diseaseAbdominal aortic aneurysmFatty liverMultidetector computed tomographyGrowth |
| spellingShingle | Ximing Wang Jingxiang Sun Na Chang Menghan Liu Shuai Zhang Association between non-alcoholic fatty liver disease and progression of abdominal aortic aneurysm: a multicenter study BMC Medical Imaging Non-alcoholic fatty liver disease Abdominal aortic aneurysm Fatty liver Multidetector computed tomography Growth |
| title | Association between non-alcoholic fatty liver disease and progression of abdominal aortic aneurysm: a multicenter study |
| title_full | Association between non-alcoholic fatty liver disease and progression of abdominal aortic aneurysm: a multicenter study |
| title_fullStr | Association between non-alcoholic fatty liver disease and progression of abdominal aortic aneurysm: a multicenter study |
| title_full_unstemmed | Association between non-alcoholic fatty liver disease and progression of abdominal aortic aneurysm: a multicenter study |
| title_short | Association between non-alcoholic fatty liver disease and progression of abdominal aortic aneurysm: a multicenter study |
| title_sort | association between non alcoholic fatty liver disease and progression of abdominal aortic aneurysm a multicenter study |
| topic | Non-alcoholic fatty liver disease Abdominal aortic aneurysm Fatty liver Multidetector computed tomography Growth |
| url | https://doi.org/10.1186/s12880-025-01559-7 |
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