Designing Novel Interfaces via Surface Functionalization of Short-Chain-Length Polyhydroxyalkanoates
Polyhydroxyalkanoates (PHA), a microbial plastic has emerged as promising biomaterial owing to the broad range of mechanical properties. However, some studies revealed that PHA is hydrophobic and has no recognition site for cell attachment and this is often a limitation in tissue engineering aspects...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Advances in Polymer Technology |
| Online Access: | http://dx.doi.org/10.1155/2019/3831251 |
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| author | S. Vigneswari J. M. Chai K. Shantini K. Bhubalan A. A. Amirul |
| author_facet | S. Vigneswari J. M. Chai K. Shantini K. Bhubalan A. A. Amirul |
| author_sort | S. Vigneswari |
| collection | DOAJ |
| description | Polyhydroxyalkanoates (PHA), a microbial plastic has emerged as promising biomaterial owing to the broad range of mechanical properties. However, some studies revealed that PHA is hydrophobic and has no recognition site for cell attachment and this is often a limitation in tissue engineering aspects. Owing to this, the polymer is tailored accordingly in order to enhance the biocompatibility in vivo as well as to suit the intended application. Thus far, these surface modifications have led to PHA being widely used in various biomedical and pharmaceutical applications such as cardiac patches, wound management, nerve, bone, and cartilage repair. This review addresses the surface modification on biomedical applications focusing on short-chain-length PHA such as poly(3-hydroxybutyrate) [P(3HB)], poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(3HB-co-3HV)]. |
| format | Article |
| id | doaj-art-77c96328421f469fba3995f5deec6eb0 |
| institution | Kabale University |
| issn | 0730-6679 1098-2329 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Polymer Technology |
| spelling | doaj-art-77c96328421f469fba3995f5deec6eb02025-02-03T01:22:59ZengWileyAdvances in Polymer Technology0730-66791098-23292019-01-01201910.1155/2019/38312513831251Designing Novel Interfaces via Surface Functionalization of Short-Chain-Length PolyhydroxyalkanoatesS. Vigneswari0J. M. Chai1K. Shantini2K. Bhubalan3A. A. Amirul4School of Fundamental Science, Universiti Malaysia Terengganu, Terengganu, MalaysiaSchool of Fundamental Science, Universiti Malaysia Terengganu, Terengganu, MalaysiaSchool of Biological Sciences, Universiti Sains Malaysia, Penang, MalaysiaMalaysian Institute of Pharmaceuticals and Nutraceuticals, NIBM, MalaysiaMalaysian Institute of Pharmaceuticals and Nutraceuticals, NIBM, MalaysiaPolyhydroxyalkanoates (PHA), a microbial plastic has emerged as promising biomaterial owing to the broad range of mechanical properties. However, some studies revealed that PHA is hydrophobic and has no recognition site for cell attachment and this is often a limitation in tissue engineering aspects. Owing to this, the polymer is tailored accordingly in order to enhance the biocompatibility in vivo as well as to suit the intended application. Thus far, these surface modifications have led to PHA being widely used in various biomedical and pharmaceutical applications such as cardiac patches, wound management, nerve, bone, and cartilage repair. This review addresses the surface modification on biomedical applications focusing on short-chain-length PHA such as poly(3-hydroxybutyrate) [P(3HB)], poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(3HB-co-3HV)].http://dx.doi.org/10.1155/2019/3831251 |
| spellingShingle | S. Vigneswari J. M. Chai K. Shantini K. Bhubalan A. A. Amirul Designing Novel Interfaces via Surface Functionalization of Short-Chain-Length Polyhydroxyalkanoates Advances in Polymer Technology |
| title | Designing Novel Interfaces via Surface Functionalization of Short-Chain-Length Polyhydroxyalkanoates |
| title_full | Designing Novel Interfaces via Surface Functionalization of Short-Chain-Length Polyhydroxyalkanoates |
| title_fullStr | Designing Novel Interfaces via Surface Functionalization of Short-Chain-Length Polyhydroxyalkanoates |
| title_full_unstemmed | Designing Novel Interfaces via Surface Functionalization of Short-Chain-Length Polyhydroxyalkanoates |
| title_short | Designing Novel Interfaces via Surface Functionalization of Short-Chain-Length Polyhydroxyalkanoates |
| title_sort | designing novel interfaces via surface functionalization of short chain length polyhydroxyalkanoates |
| url | http://dx.doi.org/10.1155/2019/3831251 |
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