The influence of clinical risk factors on the classification of human cancer-associated fibroblasts in PDAC and pancreatitis patients

The influence of clinical risk factors on the classification of human cancer-associated fibroblasts in PDAC and pancreatitis patients

Abstract Cancer-associated fibroblasts (CAFs) constitute an important cell population in the microenvironment of pancreatic cancer. They can arise from disease-associated fibroblasts (DAFs) to support or restrain tumor growth. How many CAF subtypes exist and what signals drive their development is u...

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Main Authors: Viktoria Boeker, Lena Wilke, Ana Mansourkiaei, Van Manh H. Le, Kaira A. Church, Zoltan Czigany, Bo Kong, Fernanda G. Kugeratski, Jörg Kleeff, Jürgen Weitz, Christoph Kahlert
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:BJC Reports
Online Access:https://doi.org/10.1038/s44276-025-00150-5
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