Donor Lungs’ Procurement Implementation with Ex Vivo Lung Perfusion in a Low-Volume Lung Transplant Center
(1) Background: Ex Vivo Lung Perfusion (EVLP) is a technique designed to assess and recondition marginal lungs, potentially expanding the donor pool and improving transplant outcomes (2) Methods: This retrospective study evaluated lung transplantation outcomes after EVLP. Donor lungs were assessed u...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/15/1/37 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832588139596611584 |
|---|---|
| author | Matteo Petroncini Elena Salvaterra Leonardo Valentini Silvia Bonucchi Niccolò Daddi Saverio Pastore Pietro Bertoglio Piergiorgio Solli Filippo Antonacci |
| author_facet | Matteo Petroncini Elena Salvaterra Leonardo Valentini Silvia Bonucchi Niccolò Daddi Saverio Pastore Pietro Bertoglio Piergiorgio Solli Filippo Antonacci |
| author_sort | Matteo Petroncini |
| collection | DOAJ |
| description | (1) Background: Ex Vivo Lung Perfusion (EVLP) is a technique designed to assess and recondition marginal lungs, potentially expanding the donor pool and improving transplant outcomes (2) Methods: This retrospective study evaluated lung transplantation outcomes after EVLP. Donor lungs were assessed using the Toronto protocol, with data on hemodynamics, gas exchange, and perfusion parameters collected and analyzed. Post-transplant complications and survival rates were also examined. (3) Results: Over five years, 17 EVLP procedures were performed. Despite an improvement in lung function, 47% of donor lungs were rejected after EVLP. EVLP-reconditioned lungs showed comparable survival rates to standard transplants, but complications like sepsis and primary graft dysfunction (PGD) occurred. (4) Conclusions: EVLP shows promise in expanding the donor organ availability and reducing PGD, but nearly half of the lungs assessed were rejected. Further research is necessary to optimize EVLP and address potential complications like lung injury and sepsis. |
| format | Article |
| id | doaj-art-7796233f0ceb4cdbadf6e498f1cedc0d |
| institution | Kabale University |
| issn | 2075-1729 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj-art-7796233f0ceb4cdbadf6e498f1cedc0d2025-01-24T13:38:32ZengMDPI AGLife2075-17292024-12-011513710.3390/life15010037Donor Lungs’ Procurement Implementation with Ex Vivo Lung Perfusion in a Low-Volume Lung Transplant CenterMatteo Petroncini0Elena Salvaterra1Leonardo Valentini2Silvia Bonucchi3Niccolò Daddi4Saverio Pastore5Pietro Bertoglio6Piergiorgio Solli7Filippo Antonacci8Division of Thoracic Surgery, IRCCS Azienda Ospedaliero Universitaria Di Bologna, Via Albertoni 15, 40138 Bologna, ItalyDivision of Interventional Pulmonology, IRCCS Azienda Ospedaliero Universitaria Di Bologna, Via Albertoni 15, 40138 Bologna, ItalyDivision of Thoracic Surgery, IRCCS Azienda Ospedaliero Universitaria Di Bologna, Via Albertoni 15, 40138 Bologna, ItalyDivision of Thoracic Surgery, IRCCS Azienda Ospedaliero Universitaria Di Bologna, Via Albertoni 15, 40138 Bologna, ItalyDivision of Thoracic Surgery, IRCCS Azienda Ospedaliero Universitaria Di Bologna, Via Albertoni 15, 40138 Bologna, ItalyDivision of Anesthesiology, IRCCS Azienda Ospedaliero Universitaria Di Bologna, Via Albertoni 15, 40138 Bologna, ItalyDivision of Thoracic Surgery, IRCCS Azienda Ospedaliero Universitaria Di Bologna, Via Albertoni 15, 40138 Bologna, ItalyDivision of Thoracic Surgery, IRCCS Azienda Ospedaliero Universitaria Di Bologna, Via Albertoni 15, 40138 Bologna, ItalyDivision of Thoracic Surgery, IRCCS Azienda Ospedaliero Universitaria Di Bologna, Via Albertoni 15, 40138 Bologna, Italy(1) Background: Ex Vivo Lung Perfusion (EVLP) is a technique designed to assess and recondition marginal lungs, potentially expanding the donor pool and improving transplant outcomes (2) Methods: This retrospective study evaluated lung transplantation outcomes after EVLP. Donor lungs were assessed using the Toronto protocol, with data on hemodynamics, gas exchange, and perfusion parameters collected and analyzed. Post-transplant complications and survival rates were also examined. (3) Results: Over five years, 17 EVLP procedures were performed. Despite an improvement in lung function, 47% of donor lungs were rejected after EVLP. EVLP-reconditioned lungs showed comparable survival rates to standard transplants, but complications like sepsis and primary graft dysfunction (PGD) occurred. (4) Conclusions: EVLP shows promise in expanding the donor organ availability and reducing PGD, but nearly half of the lungs assessed were rejected. Further research is necessary to optimize EVLP and address potential complications like lung injury and sepsis.https://www.mdpi.com/2075-1729/15/1/37lung transplantEVLPlung procurement |
| spellingShingle | Matteo Petroncini Elena Salvaterra Leonardo Valentini Silvia Bonucchi Niccolò Daddi Saverio Pastore Pietro Bertoglio Piergiorgio Solli Filippo Antonacci Donor Lungs’ Procurement Implementation with Ex Vivo Lung Perfusion in a Low-Volume Lung Transplant Center Life lung transplant EVLP lung procurement |
| title | Donor Lungs’ Procurement Implementation with Ex Vivo Lung Perfusion in a Low-Volume Lung Transplant Center |
| title_full | Donor Lungs’ Procurement Implementation with Ex Vivo Lung Perfusion in a Low-Volume Lung Transplant Center |
| title_fullStr | Donor Lungs’ Procurement Implementation with Ex Vivo Lung Perfusion in a Low-Volume Lung Transplant Center |
| title_full_unstemmed | Donor Lungs’ Procurement Implementation with Ex Vivo Lung Perfusion in a Low-Volume Lung Transplant Center |
| title_short | Donor Lungs’ Procurement Implementation with Ex Vivo Lung Perfusion in a Low-Volume Lung Transplant Center |
| title_sort | donor lungs procurement implementation with ex vivo lung perfusion in a low volume lung transplant center |
| topic | lung transplant EVLP lung procurement |
| url | https://www.mdpi.com/2075-1729/15/1/37 |
| work_keys_str_mv | AT matteopetroncini donorlungsprocurementimplementationwithexvivolungperfusioninalowvolumelungtransplantcenter AT elenasalvaterra donorlungsprocurementimplementationwithexvivolungperfusioninalowvolumelungtransplantcenter AT leonardovalentini donorlungsprocurementimplementationwithexvivolungperfusioninalowvolumelungtransplantcenter AT silviabonucchi donorlungsprocurementimplementationwithexvivolungperfusioninalowvolumelungtransplantcenter AT niccolodaddi donorlungsprocurementimplementationwithexvivolungperfusioninalowvolumelungtransplantcenter AT saveriopastore donorlungsprocurementimplementationwithexvivolungperfusioninalowvolumelungtransplantcenter AT pietrobertoglio donorlungsprocurementimplementationwithexvivolungperfusioninalowvolumelungtransplantcenter AT piergiorgiosolli donorlungsprocurementimplementationwithexvivolungperfusioninalowvolumelungtransplantcenter AT filippoantonacci donorlungsprocurementimplementationwithexvivolungperfusioninalowvolumelungtransplantcenter |